CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program

CDC 东南媒介传播疾病卓越中心：门户计划

• 批准号: 10551427
• 负责人: Rhoel David Ramos Dinglasan
• 金额: $ 200万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551427
• 关键词: CDC; Southeastern; Center; Excellence; Vector

This is a renewal application for the CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program (SECVBD) led by the University of Florida with both well-established and burgeoning collaborations with 13 universities with strong vector biology programs across the Southeastern United States (U.S.) and Puerto Rico. This integrated academic network carries the full and integrated support of state departments of health, state and federal agricultural agencies, U.S. military programs, national and international associations, and >60 local mosquito and vector control programs. Our proposal leverages the expertise across a broad remit of basic and applied vector biology as well as epidemiological disciplines to continue to maintain the success of our program in (i) establishing an integrated community of practice in public health entomology consisting of academic institutions throughout the Southeast and local, state, and federal public health agencies, to facilitate existing and future efforts in vector-borne disease (VBD) surveillance and control and (ii) expanding an effective academic, online, and internship-based training program in basic public health entomology to augment the cohort of personnel who are trained with the requisite knowledge and skills to quickly detect and respond to VBDs across the U.S., and (iii) initiating the drive towards an evidence-based set of recommendations and a tailored template of a “surveillance-response program” to ensure that local mosquito and vector control associations can better monitor and control VBDs in the U.S. For the next iteration of the SECVBD, we take advantage of the biocomplexity of tick- and mosquito-borne diseases in the Southeastern U.S. and Puerto Rico and leverage an integrated, data-driven, applied research program designed to produce maximal output in novel interventions and training paradigms within a 5-year period to tackle the following CDC priorities: (a) Laboratory/field evaluations of emerging technologies to suppress host-seeking ticks or disrupt pathogen transmission cycles; (b) Field studies aimed at optimizing application of tick control products to provide recommendations for pest control firms and homeowners regarding how to optimize tick suppression; (c) Assessments of the potential for incorporating tick management into existing mosquito management programs; (d) Investigations on the knowledge, attitudes, & behaviors regarding tick control methodologies, (e) Evaluation of the impact of existing public education programs on TBI risk & behaviors to prevent tick bite; (f) Field evaluations of emerging technologies to suppress mosquito adults (insecticide resistance); (g) Field evaluations of mosquito management approaches based on commercially available methods and products (both entomological and human-related outcome measures); and (h) Evaluations of the effectiveness of operational control activities targeting all mosquito stages (including insecticide resistance). The goal is to maintain our established, comprehensive, applied, and basic research program to further our understanding of VBD transmission to prevent VBDs in the continental U.S. and territories.

这是 CDC 东南媒介传播疾病卓越中心的更新应用程序：Gateway 项目 (SECVBD) 由佛罗里达大学领导，既有成熟的合作，也有新兴的合作 与美国东南部 (U.S.) 和波多黎各 13 所拥有强大载体生物学课程的大学合作 Rico 这个综合学术网络得到了国家卫生部门的全面综合支持， 州和联邦农业机构、美国军事计划、国家和国际协会以及 >60 我们的提案利用了广泛的基本领域的专业知识。 并应用载体生物学以及流行病学学科来继续保持我们的成功 (i) 建立公共卫生昆虫学综合实践社区，其中包括 整个东南部的学术机构以及地方、州和联邦公共卫生机构，以促进 媒介传播疾病 (VBD) 监测和控制方面现有和未来的努力，以及 (ii) 扩大有效的 基础公共卫生昆虫学方面的学术、在线和实习培训计划，以扩大队伍规模 接受过快速检测和应对 VBD 所需知识和技能培训的人员 (iii) 开始推动一套基于证据的建议和量身定制的建议 “监测响应计划”模板，以确保当地蚊子和病媒控制协会能够 更好地监视和控制美国的 VBD。对于 SECVBD 的下一次迭代，我们利用 美国东南部和波多黎各蜱传疾病和蚊媒疾病的生物复杂性，并利用 综合的、数据驱动的、应用研究项目，旨在在新颖的干预措施中产生最大的产出 5 年内的培训范例，以解决疾病预防控制中心的以下优先事项： (a) 实验室/现场 对抑制寻找宿主的蜱虫或破坏病原体传播周期的新兴技术进行评估； (b) 旨在优化蜱虫防治产品应用的实地研究，为害虫防治提供建议 控制公司和房主如何优化蜱抑制； (c) 评估潜在的蜱虫抑制； (d) 调查 有关蜱虫控制方法的知识、态度和行为，(e) 评估现有方法的影响 关于预防蜱虫叮咬的 TBI 风险和行为的公共教育计划 (f) 对新出现的蜱虫叮咬进行现场评估； 抑制蚊子成虫的技术（杀虫剂抗药性）； (g) 蚊子管理的实地评价 基于商业可用方法和产品（昆虫学和人类相关）的方法 (h) 评估针对所有方面的运行控制活动的有效性 蚊子阶段（包括杀虫剂抗性）的目标是维持我们既定的、全面的、 应用和基础研究计划，以进一步了解 VBD 传播，以预防 VBD 在 美国大陆和领土。