RODENT BONE MARROW MICRONUCLEUS TESTS

啮齿动物骨髓微核测试

• 批准号: 2310946
• 负责人: RAYMOND R TICE
• 金额: $ 9.2万
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2310946
• 关键词: RODENT; BONE; MARROW; MICRONUCLEUS; TESTS

The objective of this contract is to obtain information on the ability of chemicals under study by the National Toxicology Program to induce chromosomal damage in the bone marrow cells of treated laboratory mice. Specifically, the contract laboratory will conduct mouse bone marrow micronucleus tests on chemicals supplied by the NTP chemical repository using a protocol prescribed by the Program. Results of these tests will be considered along with results. from other genetic toxicity tests to help reach conclusions on the possible carcinogenic and germ cell mutagenic activity of the test chemicals.

该合同的目的是获取有关 国家毒理学计划所研究的化学物质的能力 诱导已处理的骨髓细胞中的染色体损伤 实验室小鼠。 具体而言，合同实验室将 对提供的化学物质进行小鼠骨髓小核测试 由NTP化学存储库使用的协议 程序。 这些测试的结果将被考虑 结果。 从其他遗传毒性测试来帮助达到 关于可能的致癌和生殖细胞诱变的结论 测试化学品的活性。