EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS

替代毒理学方法的评估

• 批准号: 2854372
• 负责人: RAYMOND R TICE
• 金额: --
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-16 至 2001-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2854372
• 关键词: evaluation /testing; health science research support; method development; technology /technique development; toxicant screening

The major objective of this contract is to carry out scientific support activities for the National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (Center). The Center works closely with the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) to promote the development, validation, acceptance, and use of new alternative testing methods and strategies that will be more predictive of human health and ecological effects than currently available methods and strategies. Methods are sought that incorporate new innovative technologies and scientific advances, and that provide for improved toxicity characterization, savings in time and costs, and the refinement, reduction, and replacement of animal use. The Center and ICCVAM's activities are directed at assessing the usefulness of new methods for specific risk assessment purposes. The Center coordinates the scientific peer review and interagency consideration of new test methods of multi-agency interest, convenes expert workshops to evaluate the validation status of new methods and to identify research and validation studies needed to fill critical knowledge gaps, provides administrative support for the ICCVAM and its ad hoc Test Method Expert Working Groups, prescreens test methods submitted for consideration, disseminates information on test method development and validation, and supports the Center's Scientific Advisory Committee. The objective of the contract will be to provide timely, responsive, high quality, and accurate administrative, technical, and scientific support needed to carry out these activities.

该合同的主要目的是进行科学支持 国家毒理学计划的活动中心的活动 评估替代毒理学方法（中心）。 这 中心与机构间协调委员会紧密合作 验证替代方法（ICCVAM）以促进发展， 验证，接受和使用新的替代测试方法和 将更加预测人类健康和生态的策略 效果比当前可用的方法和策略。 方法是 寻求结合新的创新技术和科学的寻求 进步，这可以改善毒性表征， 节省时间和成本，精致，减少以及 替代动物使用。 中心和ICCVAM的活动是 旨在评估新方法对特定风险的有用性 评估目的。 该中心协调科学同行评审 以及机构间考虑多机构的新测试方法 兴趣，召集专家研讨会以评估验证状态 新方法并确定所需的研究和验证研究 填补关键知识空白，为 ICCVAM及其临时测试方法专家工作组，Prescreens测试 提交考虑的方法，在测试中传播信息 方法开发和验证，并支持该中心的科学 咨询委员会。 合同的目的是提供 及时，响应迅速，高质量和准确的管理， 进行这些活动所需的技术和科学支持。