PERIODIC SCREENING FOR OCCULT STOOL BLOOD

定期筛查粪便潜血

• 批准号: 3607109
• 负责人: JACK S MANDEL
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-18 至 1994-12-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3607109
• 关键词: colon neoplasms; feces; human data; human middle age (35-64); human mortality; human old age (65+); mass screening; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; questionnaires

This randomized controlled trial is designed to determine whether screening for occult blood in the stool will reduce mortality from colorectal cancer. When the study began in 1975, a cohort of 45,000 individuals between 50 and 80 years of age, residing in the state of Minnesota, with no prior history of colorectal cancer was randomized into three groups by age, sex, and geographic region of the state. Test groups submit Hemoccult slides annually or every other year; the control group does not submit slides. Participants whose slides are positive are evaluated at the University of Minnesota Hospitals using the specified diagnostic protocol. All participants are asked to complete a short annual questionnaire concerning their health status. The study is monitored by an advisory group with expertise in statistics, epidemiology and gastroenterology. The study will continue until a significant difference in mortality is observed between screened and control groups or until it is clear that no significant difference will emerge.

这项随机对照试验旨在确定是否 筛查凳子中的神秘血会降低死亡率 结直肠癌。 研究于1975年开始时， 45,000个人在50至80岁之间，居住在 明尼苏达州，没有先前的结直肠癌史 按年龄，性别和地理区域随机分为三组 国家。 测试小组每年或每次提交血液辅实滑梯 前一年；对照组不提交幻灯片。 参与者 其幻灯片是正面的 明尼苏达州医院使用指定的诊断方案。 全部 要求参与者完成一份简短的年度问卷 关于他们的健康状况。 该研究由 咨询小组具有统计学，流行病学和 胃肠病学。 这项研究将持续到很大 在筛选和对照之间观察到死亡率的差异 团体或直到很明显，没有显着差异 出现。