Training in Neurotherapeutics for Academic Scientists

学术科学家神经治疗学培训

基本信息

批准号：
10539175
负责人：
MICHAEL A. ROGAWSKI
金额：
$ 27万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10539175
关键词：
ADME Study Academia Address Advocacy American Antibodies Area Biological Biological Assay Biological Products Biological Response Modifier Therapy Brain Brain Diseases Breathing Communities Continuing Education Critiques Development Development Plans Educational Curriculum Elements Event Faculty Formulation Funding Future Gene Transduction Agent Goals Government Individual Industry Intellectual Property Knowledge Lead Learning Legal patent Mentors Monoclonal Antibodies Oligonucleotides Participant Pharmaceutical Chemistry Postdoctoral Fellow Process Quality of life Research Research Personnel Scientist Series Societies Special Event Specialist Students Teacher Professional Development Time Toxicology Training Training Programs Viral Vector Vision Work animal efficacy apprenticeship base biological development career commercialization design disability drug development drug discovery efficacy testing experience improved instructor interest lecturer lectures meetings member nervous system disorder responsible research conduct safety testing skills small molecule success teacher

项目摘要

Project Summary/Abstract This project will develop and implement a training program in neurotherapeutics discovery and development for faculty members and advanced postdoctoral fellows, centered around a 4-day short course that will provide the trainees with the various knowledge elements required to discover and advance a neurotherapeutic agent – either small molecule or biological – to IND. The course is offered in conjunction with the American Society for Experimental Neurotherapeutics (ASENT). The training, which is designed to be applicable to diverse diseases of the nervous system, will equip students with a broad understanding of the various component steps in the neurotherapeutics drug discovery and development process. Students will learn how to identify a good drug discovery target; how to construct an assay; the elements of medicinal chemistry; how to conduct animal efficacy testing; the principles of ADME studies, safety testing, and formulation; special considerations for development of biological products, including monoclonal antibodies, oligonucleotides and viral vector gene therapies; the steps required to prepare an IND document and the principles for interacting with the FDA; the principles of intellectual property as they relate to neurotherapeutics discovery and development; and how to seek funding for academic drug discovery research. They will also receive training in responsible conduct of research. Students will be equipped with the skills to develop and coordinate an entire drug discovery and development effort, and to work collaboratively with experts in each of the component areas. The training will combine didactic lectures with active engagement activities in which the students will be challenged to utilize the lecture material to work through their own drug discovery project plan with the guidance of the area experts. The 4-day short course will be offered annually, a total of five times. After attending the short course, trainees will participate in ongoing activities that provide continuing professional development through engagement with ASENT.

项目概要/摘要该项目将制定并实施神经治疗药物发现和治疗方面的培训计划以为期 4 天的短期课程为中心，为教师和高级博士后研究员提供发展机会这将为学员提供发现和推进某一领域所需的各种知识要素神经治疗剂 - 无论是小分子还是生物 - 到 IND 该课程与 IND 一起提供。美国实验神经治疗学会 (ASENT) 的培训旨在适用于神经系统的多种疾病，将使学生对学生将了解神经治疗药物发现和开发过程中的各个组成步骤。了解如何确定良好的药物发现靶点；如何构建药物分析的要素；化学；如何进行动物功效测试；ADME 研究的原理、安全性测试和制剂；开发生物制品（包括单克隆抗体）的特殊考虑因素，寡核苷酸和病毒载体基因疗法；准备 IND 文件所需的步骤和与 FDA 互动的原则；神经治疗药物的发现和开发；以及如何为学术药物发现寻求资金他们还将接受负责任的研究培训。开发和协调整个药物发现和开发工作的技能，以及工作的技能培训将与各个组成领域的专家合作。积极参与活动，学生将面临利用讲座材料进行工作的挑战在该领域专家的指导下通过他们自己的药物发现项目计划进行为期 4 天的短期课程。每年举办一次，共计五次，学员参加短期课程后将参加。通过与 ASENT 合作提供持续专业发展的持续活动。