CLINICAL DEVELOPMENT OF ANTICANCER AGENTS

抗癌药物的临床开发

• 批准号: 3613281
• 负责人: KENNETH CHAN
• 金额: $ 3.48万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-06-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3613281
• 关键词: antineoplastics; bioassay; chemical information system; dosage; drug adverse effect; drug hypersensitivity; drug metabolism; drug quality /standard; human therapy evaluation; mass spectrometry; neoplasm /cancer pharmacology; nuclear magnetic resonance spectroscopy; prognosis

Phase I and Clinical Pharmacokinetic studies on specific investigational new drugs sponsored Division of Cancer Treatment, National Cancer Institute, and Phase II/III studies in patients with disseminated solid tumors and leukemia.

第一阶段和针对特定研究的临床药代动力学研究 新药赞助的癌症治疗部，国家癌症 研究所和II期/III期研究 肿瘤和白血病。

项目成果

A phase II study of intravenous 6-thioguanine (NSC-752) in advanced colorectal carcinoma.

静脉注射 6-硫鸟嘌呤 (NSC-752) 治疗晚期结直肠癌的 II 期研究。

• DOI: 10.1097/00000421-199206000-00011
• 发表时间: 1992
• 期刊: American journal of clinical oncology
• 作者: Rubin,J;Schutt,AJ;Pitot4th,HC
• 通讯作者: Pitot4th,HC

Amelioration of chemotherapy-induced thrombocytopenia by GM-CSF: apparent dose and schedule dependency.

GM-CSF 改善化疗引起的血小板减少症：明显的剂量和时间表依赖性。

• DOI: 10.1093/jnci/81.19.1510-a
• 发表时间: 1989
• 期刊: Journal of the National Cancer Institute
• 作者: Edmonson,JH;Long,HJ;Jeffries,JA;Buckner,JC;Colon-Otero,G;Fitch,TR
• 通讯作者: Fitch,TR

Progress report on a phase II trial of 5-fluorouracil plus citrovorum factor in women with metastatic breast cancer.

5-氟尿嘧啶加柠檬酸因子治疗转移性乳腺癌女性的 II 期试验进展报告。

• DOI: 10.1007/978-1-4684-5607-3_27
• 发表时间: 1988
• 期刊: Advances in experimental medicine and biology
• 作者: Loprinzi,CL;Ingle,JN;Schaid,DJ;Buckner,JC;Edmonson,JH
• 通讯作者: Edmonson,JH

Phase II evaluation of menogaril in patients with advanced hypernephroma.

Menogaril 在晚期肾瘤患者中的 II 期评估。

• DOI: 10.1007/bf00176980
• 发表时间: 1991
• 期刊: Investigational new drugs
• 影响因子: 3.4
• 作者: Long,HJ;Hauge,MD;Therneau,TM;Buckner,JC;Frytak,S;Hahn,RG
• 通讯作者: Hahn,RG

Phase II clinical trial of tricyclic nucleoside phosphate for advanced colorectal cancer.

三环核苷磷酸治疗晚期结直肠癌的II期临床试验。

• 发表时间: 1987
• 期刊: Cancer treatment reports
• 作者: O'Connell,MJ;Rubin,J;Hahn,RG;Kvols,LK;Moertel,CG
• 通讯作者: Moertel,CG