RESOURCE SUPPORT--CHEM/ECONOMIC/BIOL INFORMATION NEEDS

资源支持--化学/经济/生物信息需求

• 批准号: 3626280
• 负责人: ANDY CHEN
• 金额: $ 58.34万
• 依托单位: TECHNICAL RESOURCES INTERNATIONAL, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3626280
• 关键词: antineoplastics; bioassay; cancer information system; carcinogen testing; chemical carcinogen; chemical information system; chemical related neoplasm /cancer; cocarcinogen; environment related neoplasm /cancer; mutagen testing; occupational disease /disorder

This project provides a mechanism for the development of information in the areas of environmental and occupational cancer and consists of four tasks. Task I is used to support NCI's Division of Cancer Etiology's Chemical Selection Working Group in its effort to select and nominate chemicals to the National Toxicology Program for carcinogenicity bioassay. The Division of Cancer Etiology, NCI, has been, and will continue to be, the primary source for nomination of candidate chemicals. Under Task I, class studies (chemicals by use or structural class) are conducted. From such class studies and other sources (IARC monographs, ad hoc nominations, in vitro studies, etc.) chemicals are selected and summary sheets are prepared to permit systematic evaluation and selection of candidates by the Chemical Selection Working Group. Task II of this project supports the information needs of the International Agency for Research on Cancer (IARC) by providing information for inclusion in Sections 1 and 2 of the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. An average of three IARC working group meetings are held each year in Lyon, France, and a contractor representative is usually required to attend these meetings. Task III deals with the maintenance and updating of NCI's Chemical Carcinogenesis Research Information System (CCRIS). CCRIS is a scientifically evaluated and fully referenced data base containing carcinogenicity, tumor promotion, co-carcinogenicity, mutagenicity and, more recently, tumor inhibitor test results. Future expansion of this data base envisions the addition of an epidemiology file. This file is not intended to stand by itself but rather serve as a cross-linkage on specific compounds between the various files in CCRIS. Data to be included in CCRIS are evaluated by contractor, in consort with consultants, according to established criteria provided by NCI. CCRIS is resident and searchable in the National Library of Medicine's TOXNET system. Under Task IV, special studies have been prepared such as Speciesto-Species Comparison of Carcinogen Metabolism, Survey of Organic Drinking Water Contaminants, Inhibitors of Chemical Carcinogens, amongst others. To assure high quality of any state-of-the-art reports prepared under this task, such reports have been reviewed by consultants from within and outside the Federal government. Preparation of such reports will depend on availability of funding. Also under this task, the Bioassay Report Summary Handbook are being compiled and updated. This handbook now contains summaries of over 300 NCI/NTP Carcinogenesis Bioassay Technical Reports.

该项目为开发信息提供了一种机制 环境和职业癌症领域，由四个 任务。 任务I用于支持NCI的癌症病因部 化学选择工作组努力选择和提名 致癌性生物测定的国家毒理学计划的化学药品。 NCI的癌症病因学划分已经并且将继续存在 提名候选化学品的主要来源。 在任务I下， 进行了类研究（使用或结构类别的化学物质）。 从 此类班级研究和其他来源（IARC专着，临时提名， 选择化学物质，摘要表是 准备允许系统评估和选择候选人 化学选择工作组。 该项目的任务II支持 国际癌症研究机构的信息需求 （IARC）通过提供信息以包含在第1和第2节中的信息 IARC关于评估人类致癌风险的专着。 一个 平均每年在里昂举行三场IARC工作组会议 法国和承包商代表通常需要参加 这些会议。 任务III处理NCI的维护和更新 化学致癌研究信息系统（CCRIS）。 Ccris是一个 经过科学评估和完全参考的数据库 致癌性，肿瘤促进，共癌性，诱变性以及 最近，肿瘤抑制剂测试结果。 未来的扩展 数据库设想添加流行病学文件。 这个文件是 不是要站起来，而是用作交联 CCRIS中各个文件之间的特定化合物。包含的数据 在CCRIS中，承包商在与顾问的配偶中评估 根据NCI提供的既定标准。 Ccris是居民， 可在国家医学图书馆的毒品系统中搜索。 在下面 任务IV，已经准备了特殊研究，例如Speciesto-species 致癌代谢的比较，有机饮用水的调查 污染物，化学致癌物的抑制剂等。 到 确保根据此准备的任何最新报告的高质量 任务，此类报告已由内部顾问进行了审查和 在联邦政府之外。 此类报告的准备将取决于 关于资金的可用性。 同样在此任务下，生物测定报告 摘要手册正在编译和更新。 这本手册 包含300多个NCI/NTP癌变生物测定技术的摘要 报告。