Administrative Core

行政核心

• 批准号: 10516498
• 负责人: Maiken Nedergaard
• 金额: $ 7.58万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10516498
• 关键词: Advisory Committees; Astrocytes; Award; Blood Vessels; Code; Collaborations; Communication; Communities; Conflict (Psychology); Core Facility; Data; Data Analyses; Data Science; Data Science Core; Data Storage and Retrieval; Databases; Development; Doctor of Philosophy; Ensure; Environment; Faculty; Feedback; Fostering; Goals; Human; Individual; International; Intranet; Journals; Knowledge; Link; Liquid substance; Mission; Modeling; Monitor; Names; Neurosciences; Participant; Policies; Procedures; Productivity; Progress Reports; Protocols documentation; Publishing; Regulation; Research; Research Personnel; Research Project Grants; Resources; Review Committee; Running; Science; Scientist; Site Visit; Sleep; Structure; Time; Transact; United States National Institutes of Health; Viral; Work; base; data infrastructure; data resource; data sharing; data tools; experience; fluid flow; follow-up; glymphatic system; meetings; member; neural circuit; neuroimaging; neurovascular coupling; organizational structure; programs; relating to nervous system; solute; tool; tool development; undergraduate student; virtual; wasting; web site

Abstract_Administrative Core The goal of the U19 application “Neural circuit control of fluid and solute clearance during sleep” is to understand how neural activity drives periarterial CSF inflow and thereby glymphatic waste clearance across time, micro- macroscopic spatial scales, and species. The program brings together experts in neural computation, neurovascular coupling, sleep, human neuroimaging, fluid dynamics, and modeling, with a long track record of productive collaborations. The Administrative Core will serve as the hub that will coordinate all aspects of the U19 program functions. Its major goal is to facilitate the exchange of ideas and interactions and to promote the scientific excellence of the program. The Administrative Core will also oversee that the Data Core shares data within the U19 program and the outside community. The Core will provide fiscal oversight of all aspects of the program and implement decisions made by the Internal Review Committee (consisting of the project and core leaders as well as the program manager) and the External Advisory Board (consisting of 6 internationally recognized scientists with experience in collaborative studies and data sharing/modeling). One of the Administrative Core’s tasks is to continuously adjust the use of the Data Science and Viral Tool Development Cores to maximize their support of the 4 projects. The Administrative Core will also organize and submit the annual progress reports to NIH. The Core Facility will organize all routine meetings within the program, including core staff meetings, the Internal and External Advisory Board meetings, the cross-institutional administrative meetings, the annual meeting, and the site visits. Finally, the Administrative Core will optimize communication between PIs, collaborating faculty, PhD, MS, and undergraduate students, as well as research staff, to foster a team-based approach to science and facilitate frequent lab exchanges and opportunities for trainee scientific development. Altogether, the ambitions of the Administrative Core are to ensure that the overall project runs as efficiently as possible to reach the research goals and fulfills all requirements of federal and institutional regulations. Our goals are to understand, for the first time, how coordinated neural activity drives clearance of fluid and solutes during sleep; and to share with the greater neuroscience community our ideas, data, and research tools.

摘要_管理核心 U19 应用程序“睡眠期间液体和溶质清除的神经回路控制”的目标是了解 神经活动如何驱动动脉周围脑脊液流入，从而随时间、微- 该程序汇集了神经计算领域的专家， 神经血管耦合、睡眠、人类神经影像、流体动力学和建模，具有长期的跟踪记录 富有成效的合作。 行政核心将作为协调 U19 计划各个方面的枢纽 其主要目标是促进思想交流和互动，并促进科学发展。 管理核心还将监督数据核心在系统内共享数据。 U19 计划和外部社区将为该计划的各个方面提供财政监督。 执行内部审查委员会（由项目及核心领导组成）的决定 作为项目经理）和外部顾问委员会（由 6 名国际公认的科学家组成） 具有协作研究和数据共享/建模经验）。行政核心的任务之一是 不断调整数据科学和病毒工具开发核心的使用，以最大限度地支持 行政核心还将组织并向 NIH 提交年度进展报告。 核心设施将组织该计划内的所有例行会议，包括核心员工会议、内部和 外部顾问委员会会议、跨机构行政会议、年会和 最后，行政核心将优化 PI、合作教师、博士、 硕士、本科生以及研究人员，培养基于团队的科学方法和 促进频繁的实验室交流和实习生科学发展的机会。 总而言之，行政核心的目标是确保整个项目按照 尽可能有效地实现研究目标并满足联邦和机构的所有要求 我们的目标是首次了解协调的神经活动如何驱动清除。 睡眠期间的液体和溶质；并与更大的神经科学界分享我们的想法、数据和 研究工具。