PHASE I SBIR CONTRACT - TOPIC 415 - A Compact and Retrofittable Electronic Brachytherapy Source for Cancer Radiotherapy

第一期 SBIR 合同 - 主题 415 - 用于癌症放射治疗的紧凑型可改装电子近距离放射治疗源

• 批准号: 10496695
• 负责人: CHUNGUANG JING
• 金额: $ 39.99万
• 依托单位: EUCLID BEAMLABS, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2022-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10496695
• 关键词: Brachytherapy; Caliber; Characteristics; Clinical; Communities; Contracts; Development; Devices; Dimensions; Dose; Dose-Rate; Electron Beam; Electrons; Elements; Future; Goals; High-Dose Rate Brachytherapy; Hospitals; In Vitro; Laboratories; Measurement; Measures; Medical; Patients; Penetration; Phase; Photons; Radiation; Radioisotopes; Readiness; Robotics; Roentgen Rays; Small Business Innovation Research Grant; Source; Structure; System; Technology; Testing; Thick; Tissues; Weight; arm; attenuation; base; cancer radiation therapy; clinically relevant; conditioning; design; efficacy study; improved; in silico; interest; light weight; novel; prototype; user-friendly

The use of electronic brachytherapy (EB) has grown rapidly over the past decade, and is gaining significant interest from the global medical community as an improved user-friendly technology. However, the present EB machines all use electron beams at energies of 100 kV or less to generate the X-ray photons, which limits their use to low dose-rate brachytherapy. In this proposal, Euclid Beamlabs focuses on the development of an ultra-compact and light weight 1- MeV electron source to generate and deliver >250 kV X-ray photons to the patient. The device is intended to retrofit to existing brachytherapy applicators. Our proposed accelerating structure is a dielectric-based accelerator. Because of the use of high permittivity dielectrics, the transverse size of the cavity is significantly reduced, becoming comparable to the thickness of a pencil. With the help of optimized focusing elements, the beam will be transported through a 1~2-mm diameter pipe to the Bremsstrahlung radiation target, thus delivering the dose in a highly localized regime. The dimension of the pipe will be chosen for compatibility with existing brachytherapy applicators. In Phase I, we will develop a fully functioning prototype and measure its critical parameters, including the delivered electron and photon energies, the dose rate, etc. The Technical Readiness Level (TRL) of the developed technology will reach TRL4 (feasibility proved) upon the completion of Phase I.

电子近距离放射治疗 (EB) 的使用在过去十年中迅速增长，并且取得了显着的进展 作为一种改进的用户友好技术，引起了全球医学界的兴趣。然而，目前的 EB 机器 全部使用 100 kV 或更低能量的电子束来产生 X 射线光子，这限制了它们在低剂量率下的使用 近距离放射治疗。在此提案中，Euclid Beamlabs 重点开发一种超紧凑、重量轻的 1- MeV 电子源可产生 >250 kV X 射线光子并将其传送给患者。该设备旨在改装 现有的近距离放射治疗施用器。我们提出的加速结构是基于电介质的加速器。因为 使用高介电常数电介质，腔体的横向尺寸显着减小，可与 铅笔的厚度。借助优化的聚焦元件，光束将传输通过 1~2 毫米 直径管道到轫致辐射目标，从而以高度局部化的方式输送剂量。这 将选择管道尺寸以与现有近距离放射治疗施用器兼容。在第一阶段，我们将开发 一个功能齐全的原型并测量其关键参数，包括传递的电子和光子能量， 所开发技术的技术准备水平（TRL）将达到TRL4（可行性已证明） 第一阶段完成后。