CRST COVID-19 - Wayakta He

基本信息

批准号：
10491896
负责人：
Esther Erdei
金额：
$ 15.88万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10491896
关键词：
2019-nCoV Address Affect Age Alaska Native American Indians Attention Biomedical Research Businesses COVID-19 COVID-19 detection COVID-19 diagnosis COVID-19 impact COVID-19 pandemic COVID-19 risk COVID-19 severity COVID-19 susceptibility Characteristics Cheyenne Collaborations Communities Complex Data Data Collection Development Disease Disease Outbreaks Disease susceptibility Economic Conditions Electronic cigarette Employment Environmental Health Environmental Pollution Environmental Risk Factor Ethnic group Exposure to Future Generations Grant Health Sciences Heating Home Home environment Household Housing Hydrocortisone Immune response Immunity Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunologics Indoor Air Pollution Industry Inequality Infection Knowledge Lead Literature Low income Measures Missouri Native Americans New Mexico Nicotine Nitrogen Dioxide Paper Participant Personal Behavior Persons Predisposition Prevalence Preventive measure Public Health Research Research Personnel Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Risk Risk Factors Rivers SARS-CoV-2 infection Sampling Severities Severity of illness Sioux Indians Social Environment Source South Dakota Surveys Testing Time Toxic Environmental Substances Toxicant exposure Tribes Trust United States Indian Health Service Universities Viral Virus Diseases Work Youth air monitoring base cooking coronavirus disease design detection assay electronic cigarette use environmental justice environmental stressor environmental tobacco smoke ethnic minority experience health disparity health literacy high risk improved indoor air innovation low socioeconomic status member minority communities novel pandemic disease people of color pollutant population based psychosocial stressors racial and ethnic recruit response saliva sample salivary assay seroconversion social factors socioeconomics stem stressor tribal Nation tribal community vaping

项目摘要

Title: CRST COVID-19 Wayakta He? (Are you on guard against COVID?) PI: E. Erdei Project Summary Ongoing concurrent pandemics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections and toxic exposures originated from electronic cigarette (e-cig) and secondhand smoke had taken devastating tolls on minority communities in the U.S. Rather than being “the great equalizer” due to universal lack of immunity, evidence has shown that the burden of COVID-19 disease has been disproportionately felt by racial/ethnic minority and low-income communities. This stark and most current health disparity is likely due to a variety of psychosocial stressors stemming from structural inequalities that place individuals of color and/or low socioeconomic status, including American Indian/Alaska Native communities at greater risk for the contraction of SARS-CoV-2 infection and severity of COVID-19 disease. A recent literature showed that overall COVID-19 diagnosis was associated with youth use of e-cigarettes. However, that study did not look specifically at younger generation of American Indian and Alaskan Native (AI/AN), and how other factors within tribal communities affect disease susceptibility. This proposal is submitted in response to "Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences ", RFA-ES-19-011. Aim 1 will employ a community-based data collection of socioeconomic and environmental stressors in the Cheyenne River Sioux Tribal (CRST) communities in South Dakota by administering a tribal-specific survey, which will constitute the CRST SARS-CoV-2 infection prevalence collected in 300 participating CRST households with 600 distinct participants representing a wide-range of ages (18-89 yrs). The development of novel and time - sensitive data during the ongoing CRSRT pandemic on social factors and environmental toxicants will expand under Aim 2 by capturing detailed personal behaviors (i.e. vaping), stressors, Tribal housing, and by measuring environmental health factors that may impact COVID-19 disease susceptibility, severity and immune response. Detailed immunological assessment (total IgA, viral-specific IgG & IgM positivities and cortisol) will be carried out by using non-invasive saliva sampling. These measures will help us to assess the association between risk factors from Aim 1 survey data and RT-PCR confirmed SARS-CoV-2 viral infection prevalence. Based on passive air monitoring we will be able to evaluate the association between airborne exposures to nitrogen dioxide and airborne nicotine in the homes with increased susceptibility for SARS-CoV-2 infections and increased viral-specific IgM and decreased protective IgG response. We will assist CRST COVID-19 Command Center by generating a community-driven, COVID-19 targeted, public health literacy, and by capturing population-based infection susceptibility risks and specific immune response data. Our hypothesis is that increased SARS-CoV-2 infections among CRST community members are associated with vaping and indoor secondhand smoke, lower socioeconomic status, the type of heating sources used in homes, large multigenerational households (>3.4 people in one home), and living in multi-unit Tribal housing complexes.

标题：CRST COVID-19 Wayakta He？（你对新冠病毒有警惕吗？） PI：E. Erdei 项目概要严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 正在同时流行源自电子烟（e-cig）和二手烟的感染和有毒物质暴露已对美国少数族裔社区造成了毁灭性的损失，而不是由于普遍性而成为“伟大的均衡器” 缺乏免疫力，有证据表明，COVID-19 疾病的负担不成比例地受到种族/族裔少数群体和低收入社区的这种明显的、当前的健康差异可能是由于来自结构性不平等的各种社会心理压力源，使有色人种和/或社会经济地位低下，包括面临更大风险的美洲印第安人/阿拉斯加原住民社区最近的一篇文献表明，SARS-CoV-2 感染的收缩和 COVID-19 疾病的严重程度。总体而言，COVID-19 的诊断与青少年使用电子烟有关，但该研究并未发现这一点。特别是年轻一代的美洲印第安人和阿拉斯加原住民 (AI/AN)，以及其中的其他因素如何该提案是为了响应“疾病易感性机制”而提交的。环境健康科学中的时间敏感研究机会”，RFA-ES-19-011。目标 1 将在夏延采用基于社区的社会经济和环境压力源数据收集南达科他州的苏河部落 (CRST) 社区通过开展针对部落的调查，该调查将构成了在 300 个参与 CRST 家庭中收集的 CRST SARS-CoV-2 感染率代表不同年龄段（18-89 岁）的 600 名不同参与者小说和时间的发展 - 在持续的 CRSRT 大流行期间，有关社会因素和环境毒物的敏感数据将会扩大在目标 2 下，通过捕获详细的个人行为（即电子烟）、压力源、部落住房并通过测量可能影响 COVID-19 疾病易感性、严重程度和免疫反应的环境健康因素。将进行详细的免疫学评估（总 IgA、病毒特异性 IgG 和 IgM 阳性以及皮质醇）通过使用非侵入性唾液采样这些措施将帮助我们评估风险之间的关联。来自 Aim 1 调查数据和 RT-PCR 确认的 SARS-CoV-2 病毒感染流行率的因素。被动空气监测我们将能够评估空气中氮暴露之间的关联家庭中的二氧化硫和空气中的尼古丁对 SARS-CoV-2 感染的易感性增加，并且病毒特异性 IgM 增加，保护性 IgG 反应减少，我们将协助 CRST COVID-19。指挥中心，通过培养社区驱动的、有针对性的 COVID-19 公共卫生素养，并通过捕获基于人群的感染易感性风险和特定免疫反应数据我们的假设是。 CRST 社区成员中 SARS-CoV-2 感染的增加与吸电子烟有关室内二手烟、社会经济地位较低、家庭使用的热源类型、大型多代家庭（一户超过 3.4 人），以及居住在多单元部落住宅区。