HOST TUMOR INTERACTION IN BURKITTS LYMPHOMA

伯基茨淋巴瘤中宿主肿瘤的相互作用

• 批准号: 2292080
• 负责人: G. J THORBECKE
• 金额: $ 3万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1996-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2292080
• 关键词: African; Burkitt's lymphoma; CD antigens; Epstein Barr virus; SCID mouse; T cell receptor; T lymphocyte; apoptosis; clone cells; human subject; immunoglobulin isotypes; interleukin 2; molecular oncology

Our recent work on the SJL mouse model of follicular center B cell lymphoma (RCS) has established a strong link between the transcription of a novel endogenous mouse mammary tumor virus (MMTV) that serves as an indirect oncogen, mediating the vigorous superantigen-like stimulation of syngeneic CD4+Vbeta16+ T cells upon which RCS depend for their growth. RCS lymphomas share a number of salient features with Burkitt's lymphomas (BL). Both lymphomas are germinal center derived (both express the germinal center specific antigen, CD77); and like RCS lymphomas, BL tumors have T cell infiltrations that could have a potential role in the lymphomagenesis. The overall aim of this proposal is to utilize the findings in the RCS model as a basis for dissection of the role of host T cells in the development of BL. In view of the heterogeneous nature of BL tumors, we will examine a number of African BL tumors from various patients in Ghana (where BL is prevalent) in an attempt to relate tumor phenotypes to their stimulation of particular host T cell subpopulations and to their sensitivity to apoptosis.

我们最近在卵泡中心B细胞的SJL小鼠模型上的工作 淋巴瘤（RCS）已经在转录之间建立了牢固的联系 一种新型的内源性小鼠乳腺肿瘤病毒（MMTV），可作为 间接发育不全，介导剧烈的超抗原样刺激 rcs依赖于其生长的合成性CD4+ VBETA16+ T细胞。 RCS淋巴瘤与伯基特的淋巴瘤有许多显着特征 （BL）。 两种淋巴瘤都是生发中心的（都表达 生发中心特异性抗原，CD77）;像RCS淋巴瘤一样，BL肿瘤 具有T细胞浸润，可能在 淋巴作用。 该提议的总体目的是利用 RCS模型中的发现是解剖宿主作用的基础 BL开发的细胞。 鉴于BL的异质性 肿瘤，我们将检查来自各种的许多非洲BL肿瘤 加纳的患者（BL很普遍）试图关联肿瘤 表型刺激特定宿主T细胞亚群 以及他们对凋亡的敏感性。