MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA

艾滋病相关淋巴瘤的分子流行病学

• 批准号: 2769920
• 负责人: OTONIEL MARTINEZ-MAZA
• 金额: $ 26.73万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769920
• 关键词: AIDS related neoplasm /cancer; B cell lymphoma; Burkitt's lymphoma; CD antigens; Epstein Barr virus; Herpesviridae disease; biomarker; clinical research; gene rearrangement; human subject; immunoglobulin genes; molecular pathology; neoplasm /cancer epidemiology

DESCRIPTION (adapted from the Abstract): Non-Hodgkin's B-cell lymphoma is seen in greatly-elevated frequency in the acquired immunodeficiency syndrome (AIDS) and in infection with the human immunodeficiency virus (HIV). In this application, the Principal Investigator proposes studies to elucidate the molecular epidemiology of AIDS-lymphoma. In preliminary work, the Principal Investigator found that elevated serum levels of sCD23, as well as elevated levels of other immune system molecules (IgE, sCD27), precede the appearance of AIDS-lymphoma. Also, the elevated levels of sCD23 seen to precede AIDS-lymphoma may be due to the production of this molecule by tumor cells. In the proposed studies, the Investigator and associates will test the hypotheses that the over-expression of sCD23 (and other molecules) that precedes AIDS-lymphoma reflects: (1) immune dysfunction leading to B-cell hyper-activation and enhanced Ig isotype switching, perhaps contributing to the c-myc:Ig gene chromosomal translocation commonly seen in this cancer, or alternatively, (2) the production of these substances (sCD23 and other molecules) by the lymphoma cells themselves, or (3) reactivation of EBV infection. Also, they will examine the predictive value of the expression of these molecules for AIDS-lymphoma, and the expression of these molecules in lymphoma not associated with HIV infection, including African endemic Burkitt's lymphoma. Their specific aims are to: (1) define the pattern of expression of sCD23 prior to the emergence of AIDS-lymphoma; (2) determine/confirm which immune system molecules, other than sCD23, are elevated in those who develop AIDS-lymphoma; (3) determine if the measurement of serum levels of molecules other than sCD23 provides additional information for predicting the appearance of AIDS-lymphoma; and (4) determine if sCD23 or other immune system molecules are elevated in non-Hodgkin's B-cell lymphoma not associated with HIV infection, or in AIDS-lymphoma in hemophiliacs. The accomplishment of these specific aims will add valuable new information to our understanding of the molecular epidemiology of AIDS-lymphoma, as well as the role of immune dysfunction in the generation and growth of this cancer.

描述（根据摘要改编）：非霍奇金的B细胞淋巴瘤是 在获得的免疫缺陷综合征中以极高的频率观察 （AIDS）并感染人类免疫缺陷病毒（HIV）。在 这项应用，主要研究者提出了研究以阐明 艾滋病 - 淋巴瘤的分子流行病学。在初步工作中 首席研究人员发现，SCD23的血清水平升高以及 其他免疫系统分子的水平升高（IgE，SCD27），之前 艾滋病 - 淋巴瘤的出现。另外，SCD23的升高水平 先前的艾滋病 - 淋巴瘤可能是由于肿瘤产生该分子 细胞。在拟议的研究中，研究人员和同事将测试 假设SCD23（和其他分子）的过表达是 先前的艾滋病 - 淋巴瘤反映：（1）免疫功能障碍导致B细胞 过度激活和增强的Ig同型切换，也许有助于 C-Myc：Ig基因染色体易位，通常在该癌症中看到或 或者，（2）这些物质的产生（SCD23和其他 分子）由淋巴瘤细胞本身或（3）EBV重新激活 感染。另外，他们将检查表达的预测价值 这些分子用于艾滋病 - 淋巴瘤，这些分子的表达 在与艾滋病毒感染无关的淋巴瘤中，包括非洲流行 伯基特的淋巴瘤。他们的具体目的是：（1）定义 艾滋病 - 淋巴瘤出现之前的SCD23表达； （2） 确定/确认除SCD23以外的哪些免疫系统分子为 那些发展艾滋病 - 淋巴瘤的人升高； （3）确定是否 SCD23以外的血清分子水平的测量提供了 预测艾滋病淋巴瘤出现的其他信息；和 （4）确定SCD23或其他免疫系统分子是否升高 非霍奇金的B细胞淋巴瘤与HIV感染无关，或 艾滋病淋巴瘤在血友病中。这些特定目标的成就 将为我们对分子的理解添加宝贵的新信息 艾滋病 - 淋巴瘤的流行病学以及免疫功能障碍在 该癌症的产生和生长。