Atlanta Center for Microsystems Engineered Point-of-Care Technologies (ACME POCT)

亚特兰大微系统工程护理点技术中心 (ACME POCT)

• 批准号: 10488287
• 负责人: Wilbur A Lam
• 金额: $ 137.27万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2023-09-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10488287
• 关键词: Address; Adoption; Ambulances; Biomedical Engineering; Blood; Cardiac; Cardiology; Cellular Phone; Child health care; Clinical; Clinical Research; Clinical and Translational Science Awards; Clinical assessments; Collaborations; Country; Critical Care; Critical Illness; Data; Development; Device or Instrument Development; Devices; Diagnosis; Diagnostic; Doctor of Philosophy; Electronics; Engineering; Equilibrium; Faculty; Fostering; Funding; Future; General Population; Goals; Guidelines; Head; Health Services Research; Heart; Heart Diseases; Heart failure; Hematologist; Hematology; Home; Hospitals; Institutes; International; Leadership; Lung; Lung diseases; Medical Device; Medical Technology; Medicine; Microfluidics; Monitor; Movement; Nanotechnology; National Heart, Lung, and Blood Institute; Organ; Pathologic; Patients; Pediatric Hospitals; Physicians; Physicians' Offices; Play; Point of Care Technology; Process; Pulmonology; Recording of previous events; Role; Side; Signal Transduction; Sleep; System; Technology; Time; Training Activity; Translations; United States National Institutes of Health; University Hospitals; Validation; base; commercialization; cost; diagnostic value; feasibility testing; health care delivery; innovation; microchip; microsensor; microsystems; novel; operation; point of care; point of care testing; point-of-care diagnostics; portability; programs; prototype; research clinical testing; sensor; sound; success; technology development; technology training; uptake; usability

The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, and hematology, POC testing plays an especially significant role as the heart and lungs are among the most vital of organs necessitating real time diagnosis and rapid management during critical illnesses, while pathologic alternations in blood are associated with critical, systemic illness. One class of novel medical technologies that is showing promise for POC applications are microsystems-engineered technologies, that is, microchip-enabled devices ranging from microelectromechanical systems (MEMs)-based sensors, microfluidics, to even smartphone-based systems. Notable for their small size and power requirements, microchip-based systems provide the portability that is vital for POC testing. In addition, the capability of microsystems to convert sound and movement into electrical signals enable these technologies to be ideal devices to sense the dynamics of the lungs and heart and therefore to diagnose and monitor pulmonary and cardiac disorders. Moreover, microsystems engineering has brought forth the field of microfluidics, which is steadily finding applications for blood-based diagnostics, and therefore, hematologic applications. To that end, per the NHLBI's U54 POCTRN guidelines, the overall goal of the Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies for cardiac, pulmonary, hematologic and sleep applications that are beyond proof-of-concept to define their specific clinical needs, conduct clinical validation, and refine their technology, with the objective of accelerating the path to translation and clinical adoption and directly addressing the barriers thereof. The ACME POCT uniquely leverages Atlanta's nationally top-ranked clinical programs at Emory University's hospitals and Children's Healthcare of Atlanta, one of the nation's largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology (IEN), and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. The ACME POCT PI's uniquely balance the engineering and clinical sides of the Center and comprise Wilbur Lam, MD, PhD, a clinical hematologist at Emory and Georgia Tech bioengineer with expertise in POC diagnostic development and commercialization, Oliver Brand, PhD, a renowned microsystems engineer and head of Georgia Tech's IEN, and Greg Martin, MD, MSc, a clinical pulmonologist at Emory and head of clinical research in Atlanta's NIH-funded CTSA. Importantly, the leadership of the ACME POCT has a history of collaboration and track record in managing Centers that have fostered medical device development.

即时护理 (POC) 诊断功能的出现使得快速、及时的临床评估成为可能 医生办公室、救护车、家里、现场或医院，并且有可能显着 影响医疗保健服务的提供。在心脏病学、肺病学/重症监护和血液学中，POC 测试发挥着重要作用 由于心脏和肺是需要实时监测的最重要的器官之一，因此发挥着特别重要的作用 危重疾病期间的诊断和快速管理，而血液中的病理变化与之相关 患有严重的系统性疾病。一类新型医疗技术在 POC 中展现出前景 应用程序是微系统工程技术，即微芯片支持的设备，范围从 基于微机电系统 (MEM) 的传感器、微流体，甚至基于智能手机的系统。 基于微芯片的系统以其小尺寸和功耗要求而著称，提供了可移植性 对于 POC 测试至关重要。此外，微系统将声音和运动转化为电能的能力 信号使这些技术成为感知肺和心脏动态的理想设备 因此可以诊断和监测肺部和心脏疾病。此外，微系统工程还 提出了微流体领域，该领域正在稳步寻找基于血液的诊断的应用，并且 因此，血液学应用。为此，根据 NHLBI 的 U54 POCTRN 指南，总体目标 亚特兰大微系统工程 POC 技术中心 (ACME POCT) 旨在协助和支持 来自全国各地的发明家开发了基于微系统的 POC 技术，用于心脏、 肺部、血液学和睡眠应用超出了概念验证范围，无法定义其特定的临床 需求，进行临床验证，并完善其技术，目标是加速实现这一目标 翻译和临床采用并直接解决其中的障碍。 ACME POCT 独一无二 利用亚特兰大埃默里大学医院和儿童医院的全国顶级临床项目 亚特兰大的医疗保健是美国最大的儿科医院系统之一，也是国际上最大的儿科医院系统之一 佐治亚理工学院享有盛誉的微系统工程专业知识，其中包括电子研究所 和纳米技术 (IEN) 以及其他独一无二的医疗设备原型设计、创新和测试平台 设施。 ACME POCT PI 独特地平衡了中心的工程和临床方面， 包括 Wilbur Lam 医学博士、哲学博士、埃默里大学临床血液学家和佐治亚理工学院生物工程师，拥有专业知识 在 POC 诊断开发和商业化领域，Oliver Brand 博士是著名的微系统公司 乔治亚理工学院 IEN 工程师兼负责人，以及埃默里大学临床肺病学家、医学博士、理学硕士格雷格·马丁 (Greg Martin) 亚特兰大 NIH 资助的 CTSA 临床研究负责人。重要的是，ACME POCT 的领导层有 管理促进医疗设备开发的中心的合作历史和跟踪记录。