BIOLOGICALLY ACTIVE SMALL CAGE BORON COMPOUNDS

具有生物活性的小笼硼化合物

• 批准号: 3755827
• 负责人: THOMAS P ONAK
• 金额: --
• 依托单位: CALIFORNIA STATE UNIVERSITY LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3755827
• 关键词: antileukemic agent; boranes; chemical structure function; drug design /synthesis /production; drug screening /evaluation; gas chromatography mass spectrometry; infrared spectrometry; nuclear magnetic resonance spectroscopy

Biologically active derivatives of small cage boron hydride moieties, to be used in chemotherapy, will be synthesized. The emphasis will be on the synthesis of polyboranes containing a nitrogen attachment similar to those that have already shown confirmed activity against the leukemia P-388 test system. Functionalities will be introduced onto promising molecules in attempts to change the lipid solubilities of these systems, and also to provide logical precursors to the nitrogen derivatives of the polyboranes. Routes to these functionalized boron systems will be explored. Structural relationships of a variety of boron compounds will be correlated to anticancer activity and other medicinal applications. Both of the two undergraduates and the graduate student, as well as the principal investigator, will carry out laboratory research projects to accomplish these goals.

小笼硼氢化物部分的生物活性衍生物， 用于化学疗法，将合成。 重点将是 含有类似于氮的聚硼烷的合成 已经显示出对白血病P-388测试的活性 系统。 功能将引入有希望的分子 尝试更改这些系统的脂质溶解度，也尝试 为聚硼烷的氮衍生物提供逻辑前体。 将探索到这些功能化硼系统的路线。 结构 各种硼化合物的关系将与 抗癌活性和其他药用应用。 两个 本科生和研究生以及校长 研究人员将进行实验室研究项目以完成 这些目标。