Core A Administrative Core

核心 A 行政核心

• 批准号: 10480089
• 负责人: Christine C Johnson
• 金额: $ 18.23万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-06 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10480089
• 关键词: Accounting; Address; Advisory Committees; Attention; California; Charge; Childhood; Collaborations; Communication; Communication Barriers; Communities; Data Analyses; Development; Disadvantaged; Discipline; Documentation; Effectiveness; Ensure; Epidemiology; Extrinsic asthma; Fostering; Geography; Grant; Health; Health system; Human Resources; Immune; Immune system; Immunologics; Influentials; Information Dissemination; Institution; Institutional Review Boards; Investigation; Learning; Life; Manuscripts; Medical; Methodology; Michigan; Monitor; Mother-Child Relations; Newborn Infant; Output; Physiological; Process; Productivity; Progress Reports; Publications; Research; Research Activity; Research Personnel; Risk; Sampling; San Francisco; Schedule; Time; Travel; United States National Institutes of Health; Universities; Ursidae Family; Work; data sharing; experience; gut microbiota; individualized prevention; innovation; meetings; microbiota; programs; synergism

The central theme of this renewal P01 is to learn how the gut microbiota of newborn children could be altered to reduce the risk of allergic asthma in later childhood. This will require extensive interactions among epidemiological, environmental, immunologic and physiologic investigations of many potential influential variables on the microbiota of mother and child and the interactions of these microbiota to influence the developing immune system. These influences on early-life immune development likely contribute to the subsequent risk of allergic asthma during childhood. This renewal P01's Administrative Core (Core A) will again have the ultimate responsibility for assuring productivity and synergy among the four Projects and the four other Cores. Core A, under the direction of the P01 Co-Program Directors Drs. Johnson and Ownby, is the administrative umbrella responsible for optimizing scientific and operational output across this Program Project. As in the initial P01, the continuing focus of Core A will be to provide for P01 oversight and integration. Core A will oversee 1) communication and collaboration among Projects, Cores, investigators, consultants, research and administrative staff, the External Advisory Committee, and NIH; 2) the quality of methodology, data and analyses; 3) research output, primarily through presentation and publication, to promote effective and timely dissemination of findings; and 4) the optimization of scientific and operational synergy. The Core A staff will organize routine and special meetings to present and discuss results and ideas emanating from Projects and Cores, set scientific agendas for these meetings, and appoint and support a Publications Committee and External Advisory Committee. This Core will be responsible for promoting operational synergism and effectiveness through monitoring progress and coordination of operational and administrative facets of the P01. The Core A Directors will regularly review research activities, monitor the productivity and efficiency of all Projects and Cores, maintain documents, and coordinate IRB, CEAC and progress report submissions among the participating institutions. Core A will oversee matters of personnel, purchasing and fiscal management including working with NIH and grants personnel at the subcontracting institutions. This P01 is innovative in that it brings to bear expertise across multiple disciplines and institutions to address a major childhood health problem, but it requires careful and attentive administrative approaches to capitalize on this advantage while minimizing the attendant disadvantages of communication barriers introduced by disciplinary jargon, specialized expertise, different scientific perspectives, and geographic distance. While not without challenges, the Core A leaders and staff have benefited from the initial P01 experience and will assure processes are in place to once again optimize this P01 team's synergy and productivity.

此次更新 P01 的中心主题是了解新生儿的肠道微生物群是如何变化的 改变以降低儿童后期过敏性哮喘的风险。这需要各方之间广泛的互动 对许多潜在影响因素进行流行病学、环境、免疫学和生理学调查 母亲和儿童微生物群的变量以及这些微生物群之间的相互作用对母亲和儿童的影响 发展免疫系统。这些对生命早期免疫发育的影响可能有助于 儿童时期随后出现过敏性哮喘的风险。此次更新 P01 的行政核心（核心 A）将 再次对确保四个项目和 其他四个核心。核心 A，在 P01 联合项目主任 Drs 的指导下。约翰逊和欧比是 负责优化整个计划项目的科学和业务产出的行政伞。 与最初的 P01 一样，核心 A 的持续重点将是提供 P01 监督和集成。 核心 A 将监督 1) 项目、核心、调查人员、顾问、 研究和行政人员、外部咨询委员会和 NIH； 2）方法论的质量， 数据和分析； 3）研究成果，主要通过演示和出版，以促进有效和 及时传播调查结果； 4）科学与运营协同优化。核心A员工 将组织例行会议和特别会议来展示和讨论项目的成果和想法 和核心，为这些会议制定科学议程，并任命和支持出版委员会和 外部咨询委员会。该核心将负责促进运营协同和 通过监测 P01 的进展以及业务和行政方面的协调来提高有效性。 核心 A 董事将定期审查研究活动，监控所有研究人员的生产力和效率 项目和核心、维护文件并协调 IRB、CEAC 和进度报告提交 参与机构。核心A将监督人事、采购和财务管理事务 包括与 NIH 合作以及分包机构的资助人员。 P01 的创新之处在于它提供了跨学科和机构的专业知识 解决一个重大的儿童健康问题，但需要采取谨慎和周到的行政措施 利用这一优势，同时最大限度地减少沟通障碍带来的弊端 通过学科术语、专业知识、不同的科学观点和地理来引入 距离。虽然并非没有挑战，但核心 A 领导者和员工已从最初的 P01 中受益 经验并将确保流程到位，以再次优化该 P01 团队的协同作用和 生产率。