Translational Breast Cancer Research Training Program

转化乳腺癌研究培训计划

基本信息

批准号：
10475088
负责人：
Suzanne AW Fuqua
金额：
$ 19.36万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475088
关键词：
Research Training Training Programs malignant breast neoplasm

项目摘要

Abstract Improvements in the outcome for women with breast cancer require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in basic molecular and cellular research who also have an understanding of the clinical disease course will direct the most effective future of breast cancer research. Such investigators have been called “translational” because of their ability to translate basic findings into clinical strategies and vice versa. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the Breast Center affords such a combination. This is a new application for a formal Training Program that began in 1999 when what is now the Smith Breast Center was formed. All trainees work on a focused aspect of breast cancer research including 1)Hormone Action/Endocrine Therapy 2)Molecular Genomics 3)Growth Factors/Signal Transduction 4)Normal Breast Development/Breast Cancer Prevention and 5)Novel Treatment Strategies. Formal didactic courses covering Scientific writing, research grants, Biostatistics, Leadership skills, Molecular carcinogenesis, and problems in clinical translational breast cancer research are required. Progress and direction of the trainee's research project are closely monitored in bimonthly Research and Development workshops.

抽象的改善患有乳腺癌的女性的预后需要一种新兴的新品种研究员，具有扎实的基础分子基础的科学家。和细胞研究谁也了解临床疾病过程将指导此类研究人员被称为乳腺癌研究的最有效的未来。 “转化”是因为他们有能力将基本发现转化为临床策略，反之亦然。反之亦然，这种类型的培训需要资金充足的核心研究人员执行基本任务。贝勒医学院的实验室研究和出色的临床培训计划，乳房中心提供了这样的组合，这是正式培训的新应用程序。该计划于 1999 年开始，当时的史密斯乳房中心成立了。致力于乳腺癌研究的重点领域，包括 1) 激素作用/内分泌治疗 2) 分子基因组学 3) 生长因子/信号转导 4) 正常乳房发展/乳腺癌预防和 5) 新颖的正式治疗策略。教学课程涵盖科学写作、研究资助、生物统计学、领导技能、分子癌变以及临床转化乳腺癌研究中的问题是受训者的研究项目的进展和方向受到密切监控。每两个月一次的研究与开发研讨会。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy.

MAPK4 协同激活 PDK1 和 AKT 可增强癌症生长和对治疗的抵抗力。

DOI：
发表时间：
2023-08
期刊：
影响因子：
9.8
作者：
Han, Dong;Wang, Wei;Jeon, Julie Heejin;Shen, Tao;Huang, Xiangsheng;Yi, Ping;Dong, Bingning;Yang, Feng
通讯作者：
Yang, Feng

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance.

Fanconi 贫血 DNA 修复途径作为利用癌症耐药性的新机制。