Neuropathology Core

神经病理学核心

基本信息

批准号：
10475183
负责人：
BERNARDINO Francesco GHETTI
金额：
$ 35.23万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10475183
关键词：
Affect Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Archives Astrocytes Autopsy Biochemical Biological Biotechnology Brain Clinical Collaborations Collection Communities Confocal Microscopy Continuing Education Cryoelectron Microscopy DNA analysis Data Dementia Development Diagnosis Diagnostic Diagnostics Research Disease Education Electron Microscopy Etiology Evolution Extracellular Protein Family member Formalin Genetic Genetic Markers Genotype Goals Haplotypes Heterogeneity Histology Human Image Analysis Immunofluorescence Immunologic Immunohistochemistry Indiana Individual Inherited Institution International Label Laboratories Lesion Libraries Liquid substance Longitudinal Studies Measures Medical Students Medicine Methods Microglia Mission Molecular Molecular Conformation Molecular Genetics Morphology Nerve Degeneration Neurodegenerative Disorders Neurons Paraffin Embedding Pathogenesis Pathologic Pathology Patients Phenotype Physicians Proteins Quality Control RNA Research Research Methodology Research Personnel Research Project Grants Research Support Resources Risk Risk Factors Schedule Single Nucleotide Polymorphism Structure Tissue Banks Tissue Harvesting Tissue Sample Tissues United States National Institutes of Health Universities brain tissue demented digital imaging early onset imaging biomarker insight interdisciplinary approach interest laboratory facility lectures molecular marker neurodegenerative dementia neuroimaging neuropathology next generation sequencing novel novel diagnostics novel marker precision medicine programs recruit research and development symposium tau Proteins

项目摘要

Project Summary – Neuropathology Core (NPC) The Neuropathology Core (NPC) provides professional expertise for the diagnosis of tissue obtained at autopsy from patients with dementia and from control subjects, recruited by the Clinical Core (CC) of the Indiana Alzheimer’s Disease Research Center (IADRC). The NPC will also provide information about pathologic data to referring physicians, patients’ family members, and basic researchers. In addition, the NPC will be involved in providing continuing education to physicians, researchers, technicians, and the community, about new developments emerging from AD and related dementia research. Laboratory facilities and technical resources are available for the collection, and storage of human CNS tissue. Brain tissue of demented individuals is studied for diagnostic and research purposes using a multidisciplinary approach. The NPC combines data obtained by neurohistology, and immunohistochemistry to reveal the presence of abnormal proteins and determine their localization through the CNS. The NPC has expanded its mission by integrating genetics with neuropathology. Such integration is fundamental to understand disease etiology, pathogenesis and phenotypic heterogeneity. This multidisciplinary approach is the hallmark of the IADRC’s NPC and contributes to providing a definitive diagnosis of dementing disorders. The NPC supports numerous national and international scientific programs, providing scientific insights along with tissue samples from the brain library. Results from studies carried out by investigators of the NPC are presented at national and international conferences, including the annual Alzheimer Association International Conference (AAIC). In the study of patients with dementia, the concept of precision medicine is best applied through the interaction of the NPC with the CC, the Neuroimaging Core, the Genetics, Biomarker, and Biospecimen Core and the Data Core.

项目摘要 – 神经病理学核心 (NPC) 神经病理学核心 (NPC) 提供组织诊断的专业知识从痴呆症患者和对照受试者的尸检中获得，这些受试者是由印第安纳阿尔茨海默氏病研究中心 (IADRC) 的临床核心 (CC)。还向转诊医生、患者家属提供有关病理数据的信息，此外，全国人大将参与向基础研究人员提供继续教育。医生、研究人员、技术人员和社区，了解正在出现的新发展来自 AD 和相关痴呆症研究的实验室设施和技术资源。可用于人体中枢神经系统组织的采集和储存。使用以下方法研究痴呆个体的脑组织以用于诊断和研究目的 NPC 结合了神经组织学获得的数据，以及免疫组织化学揭示异常蛋白质的存在并确定其 NPC 通过将遗传学与中枢神经系统相结合，扩大了其使命。这种整合是理解疾病病因、发病机制的基础。这种多学科方法是 IADRC 的标志。 NPC 有助于提供痴呆症的明确诊断。支持众多国家和国际科学计划，提供科学见解以及来自大脑库的组织样本。全国人大调查员出席国内和国际会议，包括年度阿尔茨海默病协会国际会议（AAIC）对患有阿尔茨海默病的患者进行研究。痴呆症，精准医疗的概念最好通过NPC的互动来应用 CC、神经影像核心、遗传学、生物标志物和生物样本核心以及数据核心。