National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)

国家青少年酒精与神经发育联盟 - SRI 国际研究项目网站 (NCANDA-SRI)

• 批准号: 10471641
• 负责人: Fiona C Baker
• 金额: $ 65.87万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10471641
• 关键词: 21 year old; Abstinence; Acute; Adolescence; Adolescent; Adult; Adverse effects; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcohols; Behavioral; Biological; Brain; COVID-19 pandemic; COVID-19 pandemic effects; Clinical; Cognition; Cognitive; Communities; Complement; Computers; Data; Development; Distress; Dose; Economics; Elements; Emotional; Event; Family; Female; Frequencies; Functional Magnetic Resonance Imaging; Goals; Growth; Health; Heart Rate; Heavy Drinking; Home; Impairment; Individual; International; Learning; Life; Life Stress; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Memory; Mission; Modeling; Monitor; Outcome; Outcome Measure; Parietal; Patient Recruitments; Pattern; Personal Satisfaction; Persons; Physical activity; Polysomnography; Positioning Attribute; Process; Protocols documentation; Psychopathology; Psychosocial Factor; Quality of life; Recording of previous events; Recovery; Research Project Grants; Rest; Risk; Risk Factors; Sampling; Schools; Sex Differences; Sex Differentiation; Site; Sleep; Sleep disturbances; Specific qualifier value; Stress; Structure; Symptoms; System; Technology; Testing; Work; adolescent binge drinking; alcohol cue; alcohol effect; alcohol expectancy; alcohol use disorder; binge drinking; cognitive control; cognitive performance; cohort; cue reactivity; deep learning; design; drinking; drinking onset; early onset; emerging adult; emerging adulthood; experience; externalizing behavior; follow-up; gray matter; heart function; information processing; male; medical specialties; mobile application; modifiable risk; multimodal neuroimaging; neurodevelopment; neuroimaging; neuropsychiatry; novel; pandemic disease; recruit; relating to nervous system; response; retention rate; social; underage drinking

PROJECT SUMMARY / ABSTRACT Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.

项目概要/摘要 众所周知，在青春期开始过量饮酒会扰乱典型的神经发育模式， 增加患酒精使用障碍（AUD）的风险，并加速成年期的退化过程。 为了响应 RFA-AA-21-007，本申请提出了国家联盟的研究项目站点 未来 5 年将遵循关于青春期至成年期酒精与神经发育 (NCANDA-A) 的报告 在三个年龄段（12-14、15-17、18-21）招募的男性和女性参与者的不同社区样本 岁），当时大多数人都没有饮酒到低度饮酒者，并且在过去 8 年中在 5 个地点进行了跟踪（N=831；93%） 保留率）。监测涉及每年采集的多模式神经影像（MRI、DTI、静息状态） fMRI、任务 fMRI）、认知、临床、行为和生物数据，亲自或通过计算机远程收集 和我们的移动应用程序。这些措施现在将得到新的先进神经影像和睡眠的补充 和身体活动跟踪。该队列序贯设计独特地定位 NCANDA-A 来量化瞬态 或在特定的青少年和早期成人神经系统生长轨迹中遭受酒精相关的干扰 和功能性伴随物。 NCANDA-A 提出了四个联盟范围内的具体目标和两个专业项目目标。在目标 1 中，NCANDA-A 将调查青春期和成年初期过度饮酒对健康的影响 随后的认知表现、大脑结构和功能的发展轨迹，以及 精神病理学。目标 2 分析将识别描述神经发育模式的程度 酒精对大脑结构和功能的影响在酗酒后戒断期间会消失或持续。目标 3 将部署数据驱动的分析来识别青少年的生物、环境和行为因素（例如年龄 饮酒开始）预测成年早期过度饮酒。在目标 4 中，NCANDA-A 将量化 新冠病毒大流行对生活压力以及社会、情感和经济福祉的影响及其关系 与酒精使用模式。在目标 5 中，SRI 和匹兹堡站点将确定以下模式之间的相互作用： 饮酒、睡眠和心脏功能。在目标 6 中，UCSD、杜克大学和 OHSU 站点将确定 短期（即 4 周）戒酒会导致认知、情感、 睡眠和静息心率，以及逆转频繁暴饮暴食对大脑结构和功能的不利影响 酒精的使用。对于每个目标，发展中的性别差异、饮酒模式和历史、酒精的影响 对大脑的使用，以及性别差异的心理社会因素将受到测试。 通过在更新期间收集到成年早期的纵向数据，NCANDA-A 将提供新颖的 向公众提供有关青少年饮酒对成人功能的持久和短暂影响的信息 发现连接这些动态过程的元素和机制并识别可改变的风险因素。