Biostatistics and Data Science Core

生物统计学和数据科学核心

基本信息

批准号：
10470358
负责人：
Thomas Glenn Travison
金额：
$ 24.6万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10470358
关键词：
Address Aging American Architecture Area Biometry Biostatistics Core Boston Capsicum Clinical Cognition Collaborations Computer software Consultations Data Data Analyses Data Science Data Science Core Development Educational Activities Educational Curriculum Elderly Experimental Designs Faculty Funding Genetic Goals Industry Standard International Longevity Measurement Measures Medical History Mentorship Methodology Methods Mission Monitor Population Pragmatic clinical trial Productivity Publications Publishing Reporting Reproducibility Research Research Design Research Personnel Research Training Resources Science Scientist Software Tools Statistical Methods Survival Analysis System Time Training Training Activity Training Programs Work academic standard bioinformatics tool community center cost data management design education research implantable device improved informatics tool innovation instrument meetings novel prevent programs science education software development software repository statistics success tool tool development translational approach wearable device

项目摘要

SUMMARY/ABSTRACT The Boston OAIC programs require diverse expertise in experimental design, biostatistics, and data science to enable successful implementation of rigorous and reproducible research in diverse experimental settings and populations. To address these needs, we here propose the continuation and some expansion of the Boston OAIC’s productive and successful Biostatistical Design and Analysis Core. In keeping with the Core’s complementary foci in statistical methodology and in contemporary analytics, and research software development, this resource has been renamed the Biostatistics and Data Science Core (BDSC). The overall goals of the BDSC are to provide biostatistical and data management support to OAIC projects; collaborate with and provide consultation to OAIC investigators; to provide mentorship and training to Research Education Component (REC) and Pilot and Exploratory Science Core (PESC) awardees; and to conduct novel statistics and data science research. The BDSC’s Specific Aims are: Aim 1. To collaborate with OAIC investigators and trainees by providing biostatistical and data management support to OAIC projects Aim 2. To provide rigorous training in research design and data analysis for REC and PESC awardees, and Aim 3. To develop and disseminate novel quantitative methods and data science and bioinformatics tools aligned with the OAIC projects and priorities Aim 1 builds upon the highly successful collaborations between the BDSC's faculty and the OAIC investigators, reflected in more than 150 publications in the prior cycles. Aim 2 builds upon and extends our existing biostatistical and data science curriculum, developed during the current cycle which is undergoing continuous revision and improvement, and which is specifically tailored to provide quantitative science education both to quantitative scientists and to allied clinical researchers in aging. Aim 3 extends our current efforts both in the development of novel statistical methods in survival analysis, pragmatic clinical trials, longevity, and statistical genetics; and in the development of novel software, reproducibility, and informatics tools now in extensive use in the biomedical and Boston OAIC communities. Together these aims will enable the BDSC to cost-effectively support the OAIC's research and training initiatives. The productivity of prior cycles attests to the impact of the proposed Core on the OAIC's overall success and underscores the potential value of its continuation to the Boston OAIC's mission.

摘要/摘要波士顿 OAIC 项目需要实验设计、生物统计学和数据科学方面的多种专业知识能够在不同的实验环境中成功实施严格且可重复的研究，为了满足这些需求，我们在此建议继续扩建波士顿项目。 OAIC 富有成效且成功的生物统计设计和分析核心与核心保持一致。统计方法论和当代分析以及研究软件中的互补焦点开发后，该资源已更名为生物统计和数据科学核心 (BDSC)。 BDSC的总体目标是为OAIC项目提供生物统计和数据管理支持；与 OAIC 调查人员合作并提供咨询；为他们提供指导和培训；研究教育部分（REC）和试点与探索性科学核心（PESC）获奖者；进行新颖的统计和数据科学研究。 BDSC 的具体目标是：目标 1. 通过提供生物统计和数据管理与 OAIC 研究人员和受训人员合作支持 OAIC 项目目标 2. 为 REC 和 PESC 获奖者提供严格的研究设计和数据分析培训，以及目标 3. 开发和传播新颖的定量方法以及数据科学和生物信息学工具与 OAIC 项目和优先事项保持一致目标 1 建立在 BDSC 教师与 OAIC 研究人员之间非常成功的合作基础上，目标 2 反映在之前周期的 150 多篇出版物中。在当前周期中开发的生物统计和数据科学课程正在不断发展修订和改进，专门为提供定量科学教育而量身定制目标 3 扩展了我们在衰老领域的定量科学家和联合临床研究人员的努力。在生存分析、实用临床试验、寿命和统计方面开发新的统计方法遗传学；以及目前广泛使用的新型软件、再现性和信息学工具的开发在生物医学和波士顿 OAIC 社区。这些目标将使 BDSC 能够经济高效地支持 OAIC 的研究和培训先前周期的生产力证明了拟议的核心对 OAIC 整体的影响。成功并强调了其延续波士顿 OAIC 使命的潜在价值。