HORMONE THERAPY AND REGIONAL ADIPOSITY OF FEMALES

激素治疗与女性局部肥胖

• 批准号: 3767364
• 负责人: JANICE D WAGNER
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767364
• 关键词: Macaca fascicularis; abdomen; atherosclerosis; carbohydrate metabolism; cardiovascular disorder; computed axial tomography; coronary artery; disease /disorder proneness /risk; fat body; female; glucose tolerance test; health care; health care model; hormone therapy; lipid metabolism; mature animal; model design /development; noninsulin dependent diabetes mellitus; ovariectomy; postmenopause; women's health

Regional adiposity, specifically localization of an increased proportion of body fat in the abdominal region, is an independent risk factor for myocardial infarction, angina pectoris, stroke, noninsulin-dependent diabetes mellitus (NIDDM), and premature death. While causal mechanisms for these relationships have not been identified, excess abdominal fat has been associated with several of the risk factors for both cardiovascular disease and NIDDM, namely dyslipidemia, hyperinsulinemia, and glucose intolerance. Hormone replacement therapy has been found to prevent the accumulation of intra-abdominal fat observed in postmenopausal women. Although data are scarce, this and other observations support the theory that sex steroids affect the regulation of fat accumulation, mobilization, and distribution. The objectives of this project are: to evaluate the effects of hormone replacement therapy on regional fat distribution and characteristics; and to examine the relationships between fat distribution, risk factors for NIDDM and cardiovascular disease, and extent of coronary artery atherosclerosis in a well-characterized primate model, the female cynomolgus monkey.

区域性肥胖，特别是局部性肥胖比例增加 腹部脂肪含量是导致肥胖的独立危险因素 心肌梗塞、心绞痛、中风、非胰岛素依赖性 糖尿病（NIDDM）和过早死亡。 虽然因果机制 对于这些关系尚未确定，腹部脂肪过多 与这两种疾病的几个危险因素有关 心血管疾病和 NIDDM，即血脂异常、高胰岛素血症、 和葡萄糖不耐受。研究发现激素替代疗法可以 防止腹部脂肪堆积 绝经后妇女。尽管数据稀缺，但这和其他 观察结果支持性类固醇影响调节的理论 脂肪的积累、动员和分配。的目标 该项目是：评估激素替代疗法的效果 区域脂肪分布及特征；并检查 脂肪分布、NIDDM 危险因素和 心血管疾病和冠状动脉粥样硬化的程度 一个特征明确的灵长类动物模型，雌性食蟹猴。