Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity

使用新型多模态成像评估睡眠持续时间、血管炎症和内脏肥胖之间的关系

基本信息

批准号：
10687854
负责人：
Vaishnavi Kundel
金额：
$ 19.11万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

项目摘要

ABSTRACT The proposed training grant is designed to advance the academic career of Dr. Vaishnavi Kundel, MD, by building upon her strong background in clinical sleep medicine to engage in patient-oriented research, and develop expertise in exploring the role of sleep in cardiometabolic disease risk. Through this proposal, she will obtain multidisciplinary training to investigate chronic sleep deprivation and sleep irregularity as potentially modifiable risk factors for atherosclerosis and visceral adiposity measured using multi-modality imaging - hybrid 18fluorodeoxyglucose (FDG) PET/MRI. Research plan: The proposed research builds on Dr. Kundel's pilot studies funded by the AASM. The aims are to determine whether habitual short sleep duration and sleep irregularity are associated with increased vascular inflammation and visceral adiposity (which is strongly linked to increased CVD risk), independent of OSA (often a confounder in these associations). We will utilize multi-day actigraphy to collect objective sleep metrics, and PET/MRI to measure vascular inflammation and visceral adipose tissue (VAT) metabolic activity (a novel marker of adipose tissue inflammation) in the recruited patients. With successful completion of the proposed training and research, we hope to underscore the role of chronic sleep deprivation and sleep irregularity in cardiometabolic risk, establishing an index of imaging biomarkers for future research. Moreover, the results will provide direction for future (R01) proposals - laying the groundwork for developing multidisciplinary collaborations to elucidate mechanisms by which sleep modulates inflammation, with a long-term goal of identifying biomarkers of early cardiovascular risk in this subset of patients, and designing sleep extension studies. Career Development: Dr. Kundel's training plan features an outstanding research environment at the Icahn School of Medicine at Mount Sinai along with nationally renowned mentors and advisors with complimentary expertise. Her primary mentoring team comprises of (a) Dr. Neomi Shah, MD, MPH, MS (expert in obstructive sleep apnea [OSA] and cardiovascular (CV) diseases, and application of advanced cardiovascular imaging in OSA) (b) Dr. Indu Ayappa, PhD, (recipient of a mentored K-24 award, with expertise in OSA, sleep physiology, and use of actigraphy for objective sleep assessments) (c) Drs. Zahi Fayad and Philip Robson, PhD (experts in use of multimodality imaging for assessment of atherosclerosis and organ system biology). Her training features a combination of carefully designed coursework and practical experiences in 1) actigraphy for comprehensive assessments of objective sleep metrics 2) multi-modality cardiometabolic imaging 3) clinical study design and patient-oriented research 4) training in biomarker science for future proposals. Together, her mentors and advisors have a successful track record of mentoring junior faculty in career development awards, with extensive collaborations and grant portfolios to provide a solid foundation for Dr. Kundel's present proposal, and ultimate success in developing into an independent investigator.

抽象的拟议的培训赠款旨在推进MD Vaishnavi Kundel博士的学术生涯以她在临床睡眠药物为基础的良好背景下，从事以患者为导向的研究，发展探索睡眠在心脏代谢疾病风险中的作用方面的专业知识。通过这个建议，她将获得多学科培训，以调查慢性睡眠剥夺和睡眠不规则的可能性使用多模式成像测量的动脉粥样硬化和内脏肥胖的可修改风险因素 - 杂种 18FluorDeoxyglucose（FDG）PET/MRI。研究计划：拟议的研究以昆德尔博士的飞行员为基础由AASM资助的研究。目的是确定惯常的短睡眠时间和睡眠不规则性与增加的血管炎症和内脏肥胖有关（这是密切相关的为了增加CVD风险），独立于OSA（通常是这些关联中的混杂因素）。我们将利用多天收集客观睡眠指标和PET/MRI的动力学，以测量血管炎症和内脏招募患者中的脂肪组织（增值税）代谢活性（脂肪组织炎症的新标志）。随着拟议的培训和研究的成功完成，我们希望强调慢性的作用心脏代谢风险中的睡眠剥夺和睡眠不规则性，建立成像生物标志物的索引未来的研究。此外，结果将为未来（R01）提案提供方向 - 奠定基础为了开发多学科合作，以阐明睡眠调节炎症的机制长期目标是鉴定这一部分患者中早期心血管风险的生物标志物，以及设计睡眠扩展研究。职业发展：昆德尔博士的培训计划以出色的西奈山的伊坎医学院的研究环境以及全国知名的导师以及具有免费专业知识的顾问。她的主要指导团队由（a）医学博士Noomi Shah博士组成 MPH，MS（阻塞性睡眠呼吸暂停[OSA]和心血管疾病的专家 OSA中的高级心血管成像（b） OSA，睡眠生理学以及对客观睡眠评估的专业知识）（c）DRS。 Zahi Fayad 和Philip Robson博士（使用多模式成像的专家用于评估动脉粥样硬化和器官系统生物学）。她的培训具有精心设计的课程和实践经验的结合在1）综合评估客观睡眠指标2）多模态的综合评估。成像3）临床研究设计和面向患者的研究4）生物标志物科学培训未来建议。她的导师和顾问共同获得了指导初级教师的成功记录职业发展奖，通过广泛的合作和授予投资组合为稳固的基础昆德尔博士目前的建议，以及发展成为独立研究者的最终成功。