FASEB SRC: The Post-transcriptional Control of Gene Expression Conference: Mechanisms of RNA Decay

FASEB SRC：基因表达转录后控制会议：RNA 衰变机制

基本信息

批准号：
10467761
负责人：
ANITA H. CORBETT
金额：
$ 0.65万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-19 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10467761
关键词：
Address Animals Back Bacteria Biological Process Biology Biomedical Research COVID-19 COVID-19 pandemic Cessation of life Clinical Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communicable Diseases Communities Complex Defect Degradation Pathway Development Educational workshop Environment Enzymes Eukaryota Evaluation Faculty Florida Fostering Gene Expression Gene Expression Regulation Genetic Diseases Genetic Transcription Goals Hospitalization Human Human Genetics Jupiter Leadership Life Link Messenger RNA Modernization Modification Molecular Biology Muscle Mutation Organism Paper Participant Pathway interactions Patients Portugal Post-Transcriptional Regulation Postdoctoral Fellow Prokaryotic Cells Protein Biosynthesis Proteins RNA RNA Decay RNA Degradation RNA Interference RNA Processing RNA Viruses RNA vaccine Regulation Research Research Personnel Respondent STEM field Schedule Scientist Scourge Senior Scientist Series Site Spinal Spinal Muscular Atrophy Structure Time Transcriptional Regulation Virus Woman career career development clinical application cost disease-causing mutation enzyme pathway expectation graduate student mRNA Decay meetings men pandemic disease pathogenic bacteria pathogenic virus plant fungi response senior faculty symposium tool virtual

项目摘要

PROJECT SUMMARY The understanding that RNA degradation is critical for gene expression traces back to 1959 when Pardee, Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNA interference to experimentally degrade specific mRNAs has expanded the applications of understanding RNA decay mechanisms beyond any expectations. The clinical applications in the post-transcriptional regulation/RNA field are only starting to be realized with the initial development of Nusinersen/Spinraza® to successfully treat Spinal Muscular Atrophy and the more recent description of Milasin® to treat a single patient through a personalized RNA therapy. Of course in late 2019 into early 2020, RNA burst on to the global stage in a way we could not have predicted with the COVID-19 RNA virus impacting life as we know it across the globe. Who would or could have guessed that RNA could also represent a potential path back to a new normal via the rapid development and deployment of the first mRNA vaccines. All of these examples highlight why The FASEB meeting on ‘Post-transcriptional Regulation of Gene Expression: Mechanisms of RNA Decay’ is such a timely conference to support at this juncture. This meeting has developed into a unique conference that brings together the leading experts in RNA decay in humans and other metazoan animals, plants, fungi, viruses, and bacteria. This meeting is the 12th is a series of FASEB meetings on this topic where there is a long tradition of sharing key discoveries, building collaborations, and contributing to career development for junior scientists in the field. This meeting, which, after a two year delay due to the global pandemic, will be held June 19-23, 2022 in Jupiter, Florida, is being co-organized by three leaders in the RNA decay field, Dr. Anita H. Corbett from Emory, USA, Dr. Lori Passmore from the MRC in Cambridge UK, and Dr. Cecilia Arraiano from the ITQB/Universidade NOVA de Lisboa, Portugal. Under this leadership, we propose three specific aims: 1) Bring together the RNA degradation field and provide a forum for the presentation and discussion of the latest advances; 2) Provide an inclusive environment for establishing collaborations between researchers studying RNA degradation with different approaches and in different organisms; and 3) Encourage productive interactions between a diverse group of both junior scientists and leaders in the RNA degradation field. In keeping with a meeting goal and a common passion of the organizers, this meeting is organized with a major commitment to inclusive excellence. Among the 35 invited speakers thus far, there are 18 women (51%) and 17 men (49%). Each session is chaired by a co-chair team consisting of a senior scientist and a junior scientist. Among the 18 co-chairs, 11 (61%) are women. We are excited to include five co-chairs who are from groups traditionally underrepresented in STEM fields (28%). The long-term goal is to continue a successful meeting series that addresses modern and timely topics in RNA decay and processing while building a diverse and inclusive community of collaborative scientists and colleagues.

项目概要 RNA 降解对于基因表达至关重要的认识可以追溯到 1959 年，当时 Jacob Pardee 莫诺在一篇历史论文中证明，必须存在一种不稳定的中间导向蛋白最近，RNA 干扰在实验上降解特定 mRNA 的应用引人注目。超出了临床预期，扩展了理解 RNA 衰减机制的应用。转录后调控/RNA领域的应用才刚刚开始实现开发 Nusinersen/Spinraza® 成功治疗脊髓性肌萎缩症和最近的疾病描述 Milasin® 通过个性化 RNA 疗法治疗单个患者当然是在 2019 年底。 2020 年初，RNA 以一种我们无法预测的方式出现在全球舞台上：COVID-19 RNA 病毒影响着我们在全球范围内的生活，谁会或可能猜到 RNA 也可以代表。通过第一批 mRNA 疫苗的快速开发和部署，这是一条回归新常态的潜在途径。这些例子凸显了为什么 FASEB 会议关于“基因表达的转录后调控”： “RNA 衰变机制”是在这个时刻召开的一次非常及时的会议。参加一次独特的会议，汇集了人类和其他后生动物 RNA 衰变领域的领先专家本次会议是有关该主题的 FASEB 系列会议的第 12 次会议。这里有着分享重大发现、建立合作和为职业生涯做出贡献的悠久传统这次会议因全球范围的推迟而推迟了两年。这场大流行病大会将于 2022 年 6 月 19 日至 23 日在佛罗里达州朱庇特举行，由 RNA 的三位领导人共同组织衰变场，美国埃默里大学的 Anita H. Corbett 博士、英国剑桥 MRC 的 Lori Passmore 博士和来自葡萄牙 ITQB/Universidade NOVA de Lisboa 的 Cecilia Arraiano 在这一领导下，我们提议。三个具体目标： 1) 将 RNA 降解领域聚集在一起，并提供一个演示和讨论的论坛讨论最新进展；2）为建立合作提供包容性环境；研究人员用不同的方法和在不同的生物体中研究 RNA 降解；3) 鼓励由初级科学家和 RNA 降解领域的领导者组成的不同群体之间富有成效的互动为了与组织者的会议目标和共同热情保持一致，本次会议的组织目的是迄今为止，在 35 名受邀演讲者中，有 18 名女性（51%）。每场会议均由一名资深科学家和一名初级科学家组成的联合主席团队主持。在 18 名联合主席中，有 11 名（61%）是女性，我们很高兴有 5 名联合主席来自印度。传统上在 STEM 领域代表性不足的群体 (28%)。系列会议讨论了 RNA 衰变和加工方面的现代且及时的主题，同时建立了多元化的以及由协作科学家和同事组成的包容性社区。