MEDIC - MicroED Imaging Center - Community Engagement

MEDIC - MicroED 成像中心 - 社区参与

基本信息

批准号：
10460927
负责人：
Tamir Gonen
金额：
$ 9.47万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10460927
关键词：
Algorithms Automobile Driving Awareness Biological Books Collaborations Communities Community Outreach Computer software Country Cryoelectron Microscopy Crystallization Crystallography Data Data Analyses Data Collection Development Drug Design Educational workshop Equipment Future Goals Guidelines Information Dissemination Institution Internet Knowledge Laboratories Laboratory Research Learning Link Methodology Methods Micro Electron Diffraction Negative Staining Online Systems Parents Participant Preparation Protocols documentation Publications Recommendation Research Research Activity Research Design Research Methodology Research Personnel Resources Roentgen Rays Sampling Scientist Services Site Site Visit Structure Supervision System Techniques Technology Time Titan Training Travel United States National Institutes of Health Visit Work base community engagement computerized data processing data sharing drug discovery experience experimental study imaging facilities instrument instrumentation member operation outreach programs protocol development symposium technology research and development

项目摘要

Community engagement SUMMARY The primary goals of the community engagement of the proposed MEDIC BTRR are (1) to disseminate and to provide access to MicroED technology, and (2) to facilitate new and exciting research that perhaps is intractable by other methods. This will be mainly accomplished by providing: (1) access to MicroED instrumentation and facilitating interactions with experienced scientists to all who wish to conduct MicroED experiments as part of their own research programs, and (2) outreach to relevant scientific communities in efforts to disseminate recent MicroED advances in a direct and hands-on manner. The Gonen laboratory has worked diligently at community outreach to spread MicroED technology by holding workshops, training new users and collaborated with many groups from research laboratories across the country. To help facilitate continued expansion of MicroED and further collaborations, the MEDIC center will be open to those researchers who have demonstrated a need and desire to conduct MicroED experiments. Collaborators will be able to visit the MicroED imaging center from around the country to engage in MicroED data collection and learn first-hand how to perform the data collection and analysis. We foresee that the greatest collaborator base for MicroED will be within the existing crystallography, cryoEM communities and chemists. Crystallographers have limited experience in the technique, but a wealth of knowledge in crystallization, sample preparation, data collection, analysis using X-ray software while cryoEM, users have access to equipment and cryoEM capabilities for data collection. Chemists and those that are working on drug design and discovery are enthusiastic about MicroED for its potential in facilitating rapid structure determination from femtogram amounts of material that are intractable by other methods. Therefore, we will focus our outreach on these communities through the variety of means described below.

社区参与概括拟议的 MEDIC BTRR 社区参与的主要目标是 (1) 传播并提供对 MicroED 技术的访问，以及 (2) 促进可能棘手的新的、令人兴奋的研究通过其他方法。这主要通过提供以下方式来实现：(1) 使用 MicroED 仪器和为所有希望进行 MicroED 实验的人提供与经验丰富的科学家的互动他们自己的研究计划，以及（2）与相关科学界联系，努力传播最新的研究成果 MicroED 以直接和实践的方式取得进展。戈南实验室在社区中勤奋工作通过举办研讨会、培训新用户以及与许多人合作来推广 MicroED 技术来自全国各地研究实验室的小组。帮助促进 MicroED 的持续扩展和为了进一步合作，MEDIC 中心将向那些已证明有需要并且想要进行 MicroED 实验。合作者将能够参观 MicroED 成像中心全国各地从事MicroED数据收集并亲自学习如何进行数据收集和分析。我们预计 MicroED 最大的合作者基础将在现有的晶体学、冷冻电镜社区和化学家。晶体学家在该技术方面的经验有限，但在结晶、样品制备、数据收集、使用 X 射线软件分析方面拥有丰富的知识而冷冻电镜，用户可以使用设备和冷冻电镜功能来收集数据。化学家和那些致力于药物设计和发现的人们对 MicroED 充满热情，因为它在促进药物快速开发方面具有潜力。从飞克数量的材料中确定结构，这是其他方法难以处理的。所以，我们将通过下述各种方式将我们的外展活动重点放在这些社区上。