MEDIC - MicroED Imaging Center - Admin Core

MEDIC - MicroED 成像中心 - 管理核心

• 批准号: 10460921
• 负责人: Tamir Gonen
• 金额: $ 14.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460921
• 关键词: Advisory Committees; Automobile Driving; Biological; Budgets; Communication; Computing Methodologies; Cryoelectron Microscopy; Crystallography; Educational workshop; Ensure; Fostering; Funding; Goals; Grant; Human Resources; Joints; Leadership; Maintenance; Medical center; Methodology; Micro Electron Diffraction; Mind; Mission; Molecular Structure; Natural Products Chemistry; Online Systems; Personnel Staffing; Persons; Post-Translational Protein Processing; Preparation; Principal Investigator; Procedures; Progress Reports; Protocols documentation; Qualifying; Recommendation; Reporting; Research; Research Activity; Research Personnel; Research Support; Resolution; Resource Sharing; Resources; Role; Schedule; Secure; Site; Structure; Suggestion; Synchrotrons; Techniques; Technology; Teleconferences; Training; Twitter; United States National Institutes of Health; Update; Vision; X-Ray Crystallography; community engagement; electron diffraction; experience; image reconstruction; imaging facilities; meetings; member; nano; news; particle; programs; social media; structural biology; technology research and development; web site

ADMINISTRATION AND MANAGEMENT SUMMARY The Administrative Core (AC) will provide an organizational framework for the proposed multi-investigator project, the MEDIC – MicroED Imaging Center at UCLA. The AC will be led by the two PIs, Drs. Tamir Gonen and Pawel Penczek. The joint directorship of the MEDIC center will ensure efficient functioning of the Resource uninterrupted by other responsibilities of the PIs. The activities of this Core will include synchronization of the research and technology development of all groups, the maintenance of communications with and between Driving Biological Projects, the resolution of budgetary issues, organization of monthly meetings for an Internal Advisory Committee, a yearly meeting of an External Advisory Meeting, and up to two training and dissemination workshops per year. It will also be responsible for the preparation of the yearly Progress Report and will maintain and update the Resource Sharing facility. The center will benefit from Dr. Gonen having extensive experience in managing cryoEM resources and multi-user facility projects. Dr. Gonen established and directed several cryoEM facilities around the USA in the last 15 years, including the most prolific cryoEM user facility at the Janelia Research Campus of HHMI which was the first synchrotron-like facility for cryoEM in the world. Dr. Penczek has 20 years of successful NIH-supported research including participation in multi-PI program project and joined PI grants. In addition, for 12 years Dr. Penczek served as a Director of the UTH Structural Biology Imaging Center, a multi-user facility supporting structural biology research at UT Medical Center, including NMR, X-ray crystallography, and cryo-EM and operating under an independent budget. Under his leadership the facility grew, culminating in the successful acquisition of a UT-funded Krios TEM in 2017. Since 2017 Dr. Penczek serves as a co-director of the UT Center. Together, Drs. Gonen and Penczek will formulate an Internal Advisory Committee comprised of elite members of the Technology Research and Development projects (TRDs) and select key personnel. This committee will establish and ensure optimal operating procedures for MEDIC, access procedures and criteria for determining eligible projects. It will be also responsible for determination and the format of technology dissemination workshops and, if necessary, for reallocation of funds between TRD projects. Of utmost importance is the establishment of the External Advisory Committee. The role of this Committee will be to advise on the overall scientific direction of the project, advise on dissemination efforts and community engagement, help to maintain its focus and to stay devoted and faithful to the original mission of MEDIC. The Administrative Core will organize a yearly one-day meeting of the External Advisory Committee and its members will be expected to prepare a report that will be shared with all PIs and key personnel of the Project and with the NIH.

行政与管理 概括 行政核心（AC）将为拟议的多研究者提供组织框架 加州大学洛杉矶分校的 MEDIC – MicroED 成像中心项目将由两位 PI Tamir Gonen 博士领导。 MEDIC 中心的联合领导将确保该资源的有效运作。 该核心的活动不受 PI 的其他职责的干扰。 所有团体的研究和技术开发，维持与团体之间的沟通 推动生物项目、解决预算问题、组织内部每月会议 咨询委员会、每年一次的外部咨询会议以及最多两次的培训和传播 它还将负责编写年度进度报告并维护。 并更新资源共享设施，该中心将受益于 Gonen 博士在这方面的丰富经验。 管理冷冻电镜资源和多用户设施项目。戈南博士建立并指导了多个冷冻电镜。 过去 15 年美国各地的设施，包括 Janelia 最多产的冷冻电镜用户设施 Penczek 博士的 HHMI 研究园区是世界上第一个类似同步加速器的冷冻电镜设施。 20 年 NIH 支持的成功研究，包括参与多 PI 计划项目并加入 PI 此外，Penczek 博士曾担任 UTH 结构生物学成像中心主任 12 年。 支持 UT 医学中心结构生物学研究的多用户设施，包括 NMR、X 射线 在他的领导下，该设施不断发展壮大， 最终于 2017 年成功收购了 UT 资助的 Krios TEM。自 2017 年起，Penczek 博士担任 Gonen 博士和 Penczek 博士将共同组建一个内部咨询委员会。 由技术研发项目（TRD）的精英成员组成，并选择关键 该委员会将建立并确保医疗人员的最佳操作程序、访问权限。 它还将负责确定合格项目的程序和标准。 技术传播研讨会的形式，并在必要时在 TRD 项目之间重新分配资金。 最重要的是建立外部咨询委员会，该委员会的作用将是。 就项目的总体科学方向提供建议，就传播工作和社区提供建议 参与，有助于保持重点并保持对 MEDIC 最初使命的奉献和忠诚。 行政核心将每年组织一次为期一天的外部咨询委员会及其成员会议 预计将准备一份报告，该报告将与项目的所有 PI 和关键人员以及 NIH。