Cannabis, HIV and Mental Processing Systems (CHAMPS)

大麻、艾滋病毒和心理处理系统 (CHAMPS)

基本信息

批准号：
10458095
负责人：
Beau M Ances
金额：
$ 60.28万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458095
关键词：
Affect Brain CCL2 gene CD14 gene CD4/CD8 ratio procedure CD8-Positive T-Lymphocytes Cannabidiol Cannabis Cellularity Classification Cognition Complex Conflict (Psychology)Counseling Cross-Sectional Studies Data Dimensions Employment Exposure to General Population HIV HIV Infections Health Hippocampus (Brain)Immune Immunologic Markers Impaired cognition Inflammation Learning Legal Life Measurement Measures Medical Marijuana Memory Methodology Methods Modeling Neopterin Neuropsychology Outcome Parietal Lobe Perforant Pathway Performance Peripheral Persons Pharmaceutical Preparations Phenotype Plasma Prevalence Prevention Guidelines Psyche structure Qualifying Recreational Drugs Reporting Research Design Sampling Science Short-Term Memory Structure Survival Rate System THC concentration Temporal Lobe Testing Tetrahydrocannabinol Time Urine Viral antiretroviral therapy cognitive performance data-driven model executive function immune activation immune function immune health improved indexing insight macrophage marijuana use marijuana user monocyte neuroimaging novel phenotypic data programs substance use treatment guidelines

项目摘要

ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). Our overall hypothesis is that cannabis use leads to increases in inflammation in the peripheral and brain compartments. We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through NP and brain volumetrics. In Aim 1 we hypothesize that regular cannabis use will increase both peripheral and brain immune indices in PLWH on cART. In Aim 2 we hypothesize that regular cannabis use will lead to a worsening of NP and reductions in brain volumetrics in both PLWH on cART and HIV- controls. This proposal will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.

摘要/项目摘要该提案采用新颖的方法来确定并发艾滋病毒的关键决定因素和后果感染和经常使用大麻。我们将从外周血和大脑中获取广泛的表型数据人类免疫激活、大脑结构和神经心理表现 (NP) 的标志物接受联合抗逆转录病毒治疗 (cART) 的艾滋病毒感染者 (PLWH)（80 名经常吸食大麻的人和 80 名非吸食者）和艾滋病毒未感染者（HIV-）控制（80 名经常吸食大麻的人和 80 名非吸食者）。我们的整体假设是大麻的使用会导致外周和脑室炎症增加。我们还假设，由于经常使用大麻和艾滋病毒而产生的表型特征将通过 NP 和脑容量。在目标 1 中，我们假设经常使用大麻会增加外周和 cART 感染者的脑免疫指数。在目标 2 中，我们假设经常使用大麻会导致接受 cART 的 PLWH 和 HIV 对照患者的 NP 恶化，脑容量减少。这个提议将提供有关常规大麻和艾滋病毒对外周和大脑标记物影响的重要见解 PLWH 和 HIV 对照者的免疫功能和 NP。这些见解对于治疗策略和正在进行的艾滋病毒治疗举措。