THE ADMINISTRATION CORE (AC)

管理核心 (AC)

• 批准号: 10673892
• 负责人: Beau M Ances
• 金额: $ 70.57万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673892
• 关键词: Address; Adult; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Behavior; Blood; Brain; California; Centenarian; Clinical; Collaborations; Communication; Communities; Consult; Data; Data Analyses; Decision Making; Development; Elderly; Ensure; Environment; Evaluation; General Hospitals; Genetic; Genetic Risk; Goals; Health; Human; Impaired cognition; Individual; Informatics; Infrastructure; Institution; Leadership; Life Style; Longevity; Los Angeles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Massachusetts; Menopausal Symptom; Menopause; Minnesota; Monitor; Neurocognitive; Neuropsychology; Participant; Pathologic; Phase Transition; Phenotype; Physical activity; Physiological; Progress Reports; Research Personnel; Resistance; Resources; Site; Specimen; Stress; Teleconferences; Time; Training; Underrepresented Populations; United States National Institutes of Health; Universities; Washington; Work; aged; aging brain; allostatic load; cohort; connectome; data acquisition; data integration; data management; meetings; middle age; multiple omics; neural; neuroimaging; programs; recruit; resilience; senescence; statistics; vasomotor symptoms

ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain structural and func- tional connectivity during the lifespan. The AC will organize resources in support of the four Projects and four Cores that address resilience and vulnerability factors (e.g. genetic risk, environment stress, lifestyle behaviors, and menopause) that contribute to cognitive dysfunction, brain aging, and Alzheimer’s disease (AD) and Alz- heimer’s disease related dementias (ADRD). The AC of the AABC will provide the central infrastructure to sup- port and expand upon the Human Connectome Project for Aging (HCP-A) by continuing to collect longitudinal data from 1000 individuals across the lifespan. For many participants this will yield a total of 3-4 longitudinal time points that will be acquired over 8-10 years. The AC will be led by contact PI, Dr. Ances at Washington University in Saint Louis (WUSTL), and an Executive leadership team of co- PIs from each of four data acquisition sites, including Dr. Bookheimer at University of California Los Angeles (UCLA), Dr. Terpstra at the University of Min- nesota (UMinn), and Dr. Salat at Massachusetts General Hospital /Harvard University (MGH). In addition, the AC includes a new diversity recruitment and retention unit (DRRU) led by Drs. Babulal (WUSTL) and Diaz- Santos (UCLA). The aims of the AC include: 1) Provide program management of the AABC 2) Provide scientific direction for the AABC 3) Promote communication among investigators, the external advisory committee (EAC), and the general scientific community.

行政核心摘要 行政核心 (AC) 将支持老龄化成人大脑连接组 (AABC) 的整体工作，以 建立一个有针对性的计划，识别影响大脑结构和功能轨迹的显着变量 审计委员会将组织资源来支持这四个项目和四个项目。 解决弹性和脆弱性因素（例如遗传风险、环境压力、生活方式行为、 和更年期），这会导致认知功能障碍、大脑衰老、阿尔茨海默氏病 (AD) 和阿尔茨海默病 (Alz) AABC 的 AC 将提供中央基础设施来支持海默氏病相关痴呆症 (ADRD)。 通过继续收集纵向数据，移植并扩展人类衰老连接组计划（HCP-A） 对于许多参与者来说，这将产生总共 3-4 个纵向时间。 AC 将由华盛顿大学的联络 PI Ances 博士领导，并在 8 至 10 年内获得积分。 位于圣路易斯 (WUSTL)，以及来自四个数据采集站点的共同 PI 的执行领导团队， 包括加州大学洛杉矶分校 (UCLA) 的 Bookheimer 博士、明尼苏达大学的 Terpstra 博士 nesota（明尼苏达大学）和麻省总医院/哈佛大学（MGH）的 Salat 博士。 AC 包括一个新的多元化招聘和保留部门 (DRRU)，由 Babulal (WUSTL) 和 Diaz 博士领导。 Santos（加州大学洛杉矶分校）。AC 的目标包括： 1) 提供 AABC 的计划管理 2) 提供科学依据 AABC 的方向 3) 促进调查人员、外部咨询委员会 (EAC)、 以及整个科学界。