Training in Clinical Translational Science: Maximizing the Public Health Impact

临床转化科学培训：最大限度地提高公共卫生影响

• 批准号: 10454786
• 负责人: WILLIAM P HETRICK
• 金额: $ 30.08万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454786
• 关键词: Clinical; Public Health; Training; Translational Research

Project Summary/Abstract This program is focused on leveraging two innovative developments in medicine and clinical science to enhance the predoctoral training of psychological and brain scientists to make breakthroughs in understanding, preventing, and treating severe psychopathology. One development, the NIH initiative to foster clinical translational science (CTS), is motivated by the unmet critical need to move clinically-relevant scientific discoveries along the translational pipeline–from basic science to controlled research with clinical populations to dissemination and implementation–in order to make a substantive public mental health impact. A second development, the NIMH Research Domain Criteria (RDoC) initiative, is motivated by the critical need to develop multi-dimensional, multi-unit of analysis approaches to understanding psychopathology. Advances in clinical psychological science will come from a new generation of investigators with expertise at the intersection of these two NIH-driven developments. The ultimate goal of this training program is to maximize the likelihood of producing independent clinical research scientists and leaders with expertise in cutting-edge translational research designs, frameworks, and methodologies that will usher in breakthroughs in the identification of mental illness mechanisms, prevention, and treatment. Following a successful initial training period (years 1–4; 13 trainees), federal funds are requested to continue supporting six predoctoral trainees per year, along with two new institutionally supported trainees, for up to two years. Training opportunities center around four basic aims for each trainee: (1) to gain exposure to foundational concepts, theories, and methodologies, as well as exemplars of both CTS and multiple units of analysis informed by the RDoC; (2) apply this integrated framework to research addressing a public health issue; (3) to learn to foster collaborative opportunities that stretch the boundaries of research both along the CTS continuum and across multiple units of analysis; and, (4) develop professionally to continue this line of research as an independent clinical scientist. Trainees begin their intensive training by identifying a public health issue on which to focus their research efforts. These aims are then realized through: (a) structured research activities under the dual mentorship of a primary and a “stretch” mentor (designed to extend the research either along the CTS continuum or across a unit of analysis); (b) dual research mentoring of the trainee leading to submission of an NRSA application; (c) peer, advanced trainee, and expert guidance and feedback on their research through participation in a year- long seminar; (d) tailored doctoral qualifying examinations; (e) coursework and advanced seminars focused on addressing mental health issues within the CTS and RDoC frameworks; (f) workshops in professional development, responsible conduct of research, and grant writing; and (g) colloquia series and conference attendance to encourage networking and collaborative opportunities. Trainees work with their dual mentors to design an individualized program of study in combination with the activities listed above.

项目概要/摘要 该计划的重点是利用医学和临床科学的两项创新发展 加强心理和脑科学家的博士前培训，以在认识上取得突破， 预防和治疗严重的精神病理学的一项进展是，美国国立卫生研究院 (NIH) 倡议促进临床。 转化科学（CTS）的动机是推动临床相关科学的未满足的关键需求 转化过程中的发现——从基础科学到临床人群的对照研究 传播和实施——以便对公众心理健康产生实质性影响。 NIMH 研究领域标准 (RDoC) 倡议的开发是出于以下迫切需要： 开发多维度、多单元的分析方法来理解精神病理学的进展。 临床心理科学将来自具有专业知识的新一代研究人员 这两个 NIH 驱动的发展的交叉点是该培训计划的最终目标是最大化。 培养具有尖端专业知识的独立临床研究科学家和领导者的可能性 转化研究设计、框架和方法将带来突破 经过成功的初步培训后，确定精神疾病的机制、预防和治疗。 期间（第 1-4 年；13 名受训者），要求联邦资金继续支持每名 6 名博士前受训者 一年，以及两名新的机构支持的学员，为期两年的培训机会中心。 每个学员围绕四个基本目标：（1）接触基本概念、理论和 RDoC 提供的方法论以及 CTS 和多个分析单元的范例 (2)； 将这一综合框架应用于解决公共卫生问题的研究；（3）学会促进合作 沿着 CTS 连续体和跨多个单位扩展研究边界的机会 分析；（4）作为一名独立的临床科学家继续专业发展。 学员通过确定要重点研究的公共卫生问题来开始强化培训 然后通过以下努力实现这些目标：(a) 在双重指导下开展结构化研究活动 主要导师和“延伸”导师（旨在沿着 CTS 连续体或跨领域扩展研究） (b) 对受训者进行双重研究指导，以提交 NRSA 申请； 同行、高级实习生和专家通过参与一年来对他们的研究提供指导和反馈 长期研讨会；(d) 量身定制的博士资格考试；(e) 重点关注的课程和高级研讨会 在 CTS 和 RDoC 框架内解决心理健康问题 (f) 专业研讨会； 开发、负责任的研究和资助写作；以及（g）系列研讨会和会议 出席以鼓励学员与他们的双重导师合作并建立联系和合作机会。 结合上述活动设计个性化的学习计划。