DPH PROJECT 2

DPH 项目 2

• 批准号: 7607639
• 负责人: NAVEED HUSSAIN
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607639
• 关键词: Auditory; Behavior assessment; Biological Markers; Blood Circulation; Carcinogens; Chemicals; Child; Computer Retrieval of Information on Scientific Projects Database; Cytokine Receptors; Fetal Development; Functional disorder; Funding; Grant; IL8 gene; Infant; Inflammatory; Institution; Interleukin-8; Mediator of activation protein; Neonatal; Neuronal Injury; Neurons; Newborn Infant; Nicotine; Nicotinic Receptors; Personal Satisfaction; Pregnancy; Process; Production; Reading; Research; Research Personnel; Resources; Risk; Role playing therapy; School-Age Population; Smoker; Source; Testing; Tissues; Tobacco smoke; Umbilical Cord Blood; United States National Institutes of Health; cytokine; fetal; maternal cigarette smoking; non-smoker; receptor; spelling

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tobacco smoke contains over 4000 chemicals and 60 carcinogens, thus the mechanisms by which maternal smoking causes fetal and infant harm are likely to be multi-factorial. Studies suggest that infants born to smokers have altered auditory processing, which has been correlated with deficits in reading and spelling in school-aged children. Nicotine exerts its effects mostly via specific receptors in both neuronal and non-neuronal tissue which may, in turn modulate expression of cytokines, which act as mediators. However the roles played by nicotinic receptors and cytokines in fetal development have not been well studied. Objective:1.To determine if maternal smoking during pregnancy is associated with infant abnormalities in the auditory component of the Brazelton Neonatal Behavioral Assessment Scale (BNBAS),a scale devised to test auditory function.2. To determine if maternal smoking increases/alters nicotinic receptor (nAChR) expression in umbilical cord blood and cord tissue,a non-neuronal tissue that is more readily available .3.To determine if maternal smoking causes an increased level of the inflammatory cytokine interleukin-8(IL-8) in fetal circulation, which in turn may be related to neuronal injury and auditory dysfunction in infants and in turn will serve as a potential biomarker to predict which babies are at risk.4. Differences in nAChR expression and IL-8 production will be correlated with auditory functioning in newborn infants of smokers and non-smokers.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 烟草烟雾含有超过4000种化学物质和60种致癌物，因此产妇吸烟会导致胎儿和婴儿危害的机制可能是多因素的。研究表明，吸烟者出生的婴儿已经改变了听觉加工，这与学龄儿童的阅读和拼写缺陷有关。尼古丁主要通过神经元和非神经元组织中的特定受体发挥作用，这反过来又可能调节细胞因子的表达，后者充当介质。然而，烟碱受体和细胞因子在胎儿发育中扮演的角色尚未得到很好的研究。目的：1。确定怀孕期间的孕产妇是否与Brazelton新生儿行为评估量表（BNBAS）的听觉成分中的婴儿异常有关，该量表设计用于测试听觉功能。2。 To determine if maternal smoking increases/alters nicotinic receptor (nAChR) expression in umbilical cord blood and cord tissue,a non-neuronal tissue that is more readily available .3.To determine if maternal smoking causes an increased level of the inflammatory cytokine interleukin-8(IL-8) in fetal circulation, which in turn may be related to neuronal injury and auditory dysfunction in infants and in turn将作为预测哪些婴儿有风险的潜在生物标志物。4。 NACHR表达和IL-8产生的差异将与吸烟者和非吸烟者的新生婴儿的听觉功能相关。