Longitudinal Study of Health and Ageing in Kenya (LOSHAK)

肯尼亚健康与老龄化纵向研究 (LOSHAK)

• 批准号: 10427945
• 负责人: Joshua Robert Ehrlich
• 金额: $ 33.86万
• 依托单位: AGA KHAN UNIVERSITY (KENYA)
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10427945
• 关键词: Accounting; Address; Adopted; Adult; Africa; Africa South of the Sahara; African; Age; Aging; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Climate; Cognition; Cohort Studies; Collection; Community Health; Complex; Computer Assisted; Computer software; Consumption; Country; Data; Data Collection; Demographic Transitions; Development; Droughts; Economics; Elderly; Enrollment; Environmental Exposure; Epidemiologic Monitoring; Epidemiology; Family; Floods; Future; Goals; Health; Health and Retirement Study; Heat Waves; Home; Human Resources; Income; Individual; Infrastructure; Intervention; Interview; Kenya; Knowledge; Longitudinal Studies; Measurement; Measures; Mental Health; Michigan; Modeling; Participant; Personal Satisfaction; Persons; Physiological; Population; Population Growth; Population Study; Probability Samples; Procedures; Process; Protocols documentation; Research; Research Support; Resources; Risk Factors; Sampling; Sister; South Africa; Strategic Planning; Surveys; System; Training; Universities; Work; age group; aged; aging population; blood-based biomarker; climate change; climate impact; cognitive testing; cohort; computer infrastructure; computerized data processing; data harmonization; data sharing; design; disability; experience; follow-up; health economics; infrastructure development; instrument; low and middle-income countries; molecular marker; pilot test; population based; recruit; success; trend

The proposed project aims to build the infrastructure needed to successfully field the Longitudinal Study of Health and Ageing in Kenya (LOSHAK), a population-based cohort study of adults age ≥45 years in Kenya. This will be a new study in the Health and Retirement Study (HRS) network of harmonized studies on aging. Key focus areas of LOSHAK will include Alzheimer’s disease and related dementias (ADRD), mental health, the health and economic impacts of climate change and air pollution, and factors influencing late-life economic well-being. Kenya currently has a relatively young population, but is poised to experience very rapid aging of its population over the next 30 years. Accordingly, it is vitally important to begin studying both population-level trends, as well as individual aging trajectories in order to characterize risk factors for health, disability, and well-being in the Kenyan context. Importantly, there is a major gap in population-level data on aging in Sub-Saharan Africa, and LOSHAK will be only the second study in the HRS Network from the region. In order to carry out the proposed infrastructure development aims, we will leverage our study team’s ongoing epidemiologic surveillance platform, the Kaloleni/Rabai Community Health and Demographic Surveillance System (KRHDSS) in coastal Kenya, which includes more than 14,000 individuals age ≥45 years. In this application we propose the following aims: 1) to adapt and validate existing HRS network measures and new survey and data collection protocols (molecular biomarkers, physiological measures) within the KRHDSS; 2) To design Wave 1 of LOSHAK, including a sampling strategy to draw a regionally-representative probability sample; and 3) To develop a long-term strategic plan for expansion towards a nationally-representative panel study of aging in Kenya for Wave 2 of LOSHAK. The KRHDSS platform will enable us to efficiently recruit and enroll participants and will contribute to our success carrying out these aims. Throughout the infrastructure development process, we will work closely with the HRS and the HRS Sister Studies Network in order to maximize comparability with the measures and processes (e.g., training in HRS interview administration, use of computer-assisted personal interviewing software, data processing, etc) used in other HRS network studies. Thus, LOSHAK will ultimately provide key population-based and comprehensive measures on health and economic well-being from mid- to late-life. These data will be harmonized in order to enable cross-national comparisons with high-income and other low- and middle-income countries, thereby expanding opportunities to understand health and aging in a global context.

拟议项目旨在建设成功开展健康纵向研究所需的基础设施 肯尼亚老龄化 (LOSHAK)，这是一项针对肯尼亚 45 岁以上成年人的人群队列研究。 健康与退休研究（HRS）协调老龄化研究网络中的一项新研究。 LOSHAK 的主题将包括阿尔茨海默氏病和相关痴呆症 (ADRD)、心理健康、健康和 气候变化和空气污染的经济影响，以及影响晚年经济福祉的因素。 肯尼亚目前人口相对年轻，但人口老龄化速度很快 因此，在未来 30 年里，开始研究人口水平的趋势也至关重要。 作为个体衰老轨迹，以描述健康、残疾和福祉的风险因素 重要的是，撒哈拉以南非洲地区的人口老龄化数据存在重大差距。 LOSHAK 将是该地区 HRS 网络中的第二项研究，以开展拟议的研究。 基础设施发展目标，我们将利用我们研究团队正在进行的流行病学监测平台， 肯尼亚沿海的卡洛莱尼/拉拜社区健康和人口监测系统 (KRHDSS)， 其中包括超过 14,000 名年龄≥45 岁的人。在此应用中，我们提出以下目标： 1) 调整和验证现有的 HRS 网络措施以及新的调查和数据收集协议（分子 2) 设计LOSHAK的Wave 1，包括采样 制定具有区域代表性的概率样本的策略；以及 3) 制定长期战略计划 扩大肯尼亚第二波 LOSHAK 的全国代表性老龄化小组研究。 KRHDSS 平台将使我们能够有效地招募和注册参与者，并将为我们的成功做出贡献 为了实现这些目标，我们将在整个基础设施开发过程中与 HRS 密切合作。 和 HRS 姐妹研究网络，以最大限度地提高与措施和流程的可比性（例如， HRS 面试管理培训、计算机辅助个人面试软件的使用、数据 处理等）用于其他HRS网络研究因此，LOSHAK最终将提供基于人群的关键。 这些数据将是关于中年到晚年健康和经济福祉的综合衡量标准。 进行协调，以便能够与高收入和其他低收入和中等收入国家进行跨国比较 国家，从而扩大在全球背景下了解健康和老龄化的机会。