International Symposia on Recent Advances in Otitis Media

中耳炎最新进展国际研讨会

• 批准号: 10413954
• 负责人: Lauren O Bakaletz
• 金额: $ 3.99万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-04 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413954
• 关键词: Acute; Address; Adolescent; Antibiotics; Area; Authorization documentation; Bacterial Antibiotic Resistance; Basic Science; Bioinformatics; Biomedical Engineering; Biotechnology; Books; California; Child; Childhood; Chronic; Clinical; Clinical Nurse Specialists; Collaborations; Communication; Communication impairment; Complex; Destinations; Development; Diagnosis; Discipline; Disease; Education; Ensure; Epigenetic Process; Eustachian Tube; Evaluation; Event; Faculty; Family Caregiver; Feedback; Financial Support; Fostering; Functional disorder; Funding; Future; Future Generations; Genetic; Goals; Healthcare; Healthy People 2020; Hearing; Hyperplasia; Immune; Immunologics; Immunology; Infection; Inflammation; International; Israel; Journals; Knowledge; Laboratories; Licensure; Life; Link; Los Angeles; Mentorship; Microbe; Microbial Biofilms; Modeling; Molecular; Mucous Membrane; Mucous body substance; National Institute on Deafness and Other Communication Disorders; Natural Immunity; Nature; Ohio; Oral; Otitis Media; Participant; Pathogenesis; Pathway interactions; Patients; Peer Review; Postdoctoral Fellow; Predisposition; Prevalence; Prevention strategy; Production; Public Health; Publications; Quality of life; Recommendation; Reflux; Reporting; Research; Research Personnel; Research Priority; Resolution; Scholarship; Schools; Senior Scientist; Sensory Disorders; Services; Societies; Speed; Strategic Planning; Structure; Students; Sweden; Talents; Targeted Research; Technology; Time; Underrepresented Minority; Upper Respiratory Infections; Vaccination; Vaccines; Work; accurate diagnosis; animal model development; base; burden of illness; care burden; career; cost; disadvantaged population; improved; innovation; interest; microbial; microbiome; middle ear; minority scientist; new therapeutic target; outreach; patient advocacy group; posters; precision genomic medicine; prevent; programs; social media; socioeconomics; success; symposium; systematic review; targeted treatment; tissue repair

PROJECT SUMMARY Partial support is being requested for three International Symposia on Recent Advances in Otitis Media. The worldwide prevalence of otitis media (OM) and alarming increase in antibiotic resistant bacteria that cause OM make this a serious public health problem. Thus, there is a pressing need for better ways to diagnose, treat and ultimately, prevent OM. To do so however requires a complete understanding of all aspects of this pediatric disease, a stated goal of both Healthy People 2020 (Hearing and Other Sensory or Communication Disorders, ENT-VSL-2: “Reduce otitis media in children and adolescents”), and the NIDCD strategic plan FY 2017-2021, wherein Priority Area 2 – Understanding Diseases and Disorders, declares a mandate to improve our understanding of the susceptibility and pathogenesis of OM as related to genetics, prior upper respiratory tract infection, Eustachian tube dysfunction and reflux, bacterial biofilms and microbiome, polymicrobial infections, dysregulation of innate immunity, inflammation and mucus production, mucosal hyperplasia and dysregulation of the resolution of inflammation and tissue repair. Defining the immune pathways for effective middle ear protection by vaccines and identification of new therapeutic targets as well as development of animal models of acute and chronic OM, determination of the impact of vaccination on disease prevalence and infection by other microbes are also cited as major goals within this priority research area. The objectives of the International Symposia on Recent Advances in Otitis Media are fully and uniquely aligned with these strategic goals. We strongly believe that the speed of scientific discovery requires regular broad and in-depth review of the research progress in OM every two years. Importantly, an additional opportunity to define and formulate recommendations for future research directions and funding every four years by the convening of an integrated Research Conference within the Symposium (occurs during U.S.-convened symposia) is also of great value to our collective efforts to identify and promote new and innovative research opportunities. Thereby, with permission and recommendation from NIDCD staff, herein we request support that will span a period of 5 years, during which we will convene the 20th , 21st and 22nd International Symposia on Recent Advances in Otitis Media (in 2019, 2021 and 2023, respectively). The 20th Symposium will be convened June 9-13 in Los Angeles, California; the 21st Symposium will be convened June 6-10 in Tel Aviv, Israel; and the 22nd Symposium will be convened at a U.S. destination that will be decided at the 20th Symposium. These Symposia are expected to foster improved communication amongst diverse research disciplines in the OM research field and help close gaps in our collective knowledge and understanding of the pathogenesis as well as the diagnosis, treatment and/or potential for immunological resolution of OM. This Symposium has also consistently attracted young investigators from many disciplines and from around the world, thus ensuring a future generation of both basic science and clinician investigators who will continue to move the field forward.

项目概要 正在请求为三场中耳炎最新进展国际研讨会提供部分支持。 中耳炎 (OM) 的全球患病率以及引起 OM 的抗生素耐药细菌的惊人增加 因此，迫切需要更好的方法来诊断和治疗。 但最终，要防止 OM 发生，需要全面了解这一点。 儿科疾病，《健康人 2020》（听力和其他感觉或交流）的既定目标 疾病，ENT-VSL-2：“减少儿童和青少年中耳炎”），以及 NIDCD 财年战略计划 2017-2021 年，优先领域 2 – 了解疾病和失调，宣布了一项改进的任务 我们对 OM 易感性和发病机制的理解与遗传学、先前的上呼吸道疾病有关 道感染、咽鼓管功能障碍和反流、细菌生物膜和微生物群、多种微生物 感染、先天免疫失调、炎症和粘液产生、粘膜增生和 炎症解决和组织修复的失调定义有效的免疫途径。 通过疫苗保护中耳、确定新的治疗靶点以及开发 急性和慢性 OM 动物模型，确定疫苗接种对疾病患病率的影响以及 其他微生物的感染也被列为该优先研究领域的主要目标。 中耳炎最新进展国际研讨会完全且独特地与这些内容保持一致 我们坚信科学发现的速度需要定期的广泛和深入。 重要的是，每两年审查一次 OM 的研究进展。 每四年召开一次会议，为未来的研究方向和资金提供建议 研讨会内的综合研究会议（在美国召开的研讨会期间举行）也是 对我们发现和促进新的创新研究机会的集体努力具有重大价值。 因此，在 NIDCD 工作人员的许可和推荐下，我们在此请求跨领域的支持 为期5年，期间我们将召开第20届、第21届和第22届近期国际研讨会 中耳炎进展（分别于2019年、2021年和2023年）第20届研讨会将于6月召开。 9-13日在加利福尼亚州洛杉矶举行；第21届研讨会将于6月6-10日在以色列特拉维夫举行； 第 22 届研讨会将在美国举行，地点将在第 20 届研讨会上决定。 研讨会预计将促进 OM 不同研究学科之间的交流 研究领域并有助于缩小我们对发病机制的集体知识和理解的差距 本次研讨会还讨论了 OM 的诊断、治疗和/或免疫学解决的潜力。 不断吸引来自世界各地的许多学科的年轻研究人员，从而确保 下一代基础科学和临床研究人员将继续推动该领域向前发展。

项目成果

Panel 6: Otitis media and associated hearing loss among disadvantaged populations and low to middle-income countries.

第 6 组：弱势群体和中低收入国家的中耳炎和相关听力损失。

• DOI: 10.1016/j.ijporl.2019.109857
• 发表时间: 2020-01-21
• 期刊: International journal of pediatric otorhinolaryngology
• 影响因子: 1.5
• 作者: A. Leach;P. Homøe;C. Chidziva;H. Gunasekera;K. Kong;M. Bhutta;R. Jensen;S. Tamir;S. Das;P. Morris
• 通讯作者: P. Morris

ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic.

ISOM 2023 研究小组 5：干预措施 - 疫苗和预防、内科和外科治疗以及 COVID-19 大流行的影响。

• 发表时间: 2024-01
• 影响因子: 1.5
• 作者: Pelton, Stephen I;Hullegie, Saskia;Leach, Amanda J;Marchisio, Paola;Marom, Tal;Sabharwal, Vishakha;Shaikh, Nader;Tähtinen, Paula A;Venekamp, Roderick P
• 通讯作者: Venekamp, Roderick P

Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019.

第 7 部分 - 中耳炎的发病机制 - 2015 年至 2019 年文献综述。

• 发表时间: 2020-03
• 影响因子: 1.5
• 作者: Thornton, R B;Hakansson, A;Hood, D W;Nokso;Preciado, D;Riesbeck, K;Richmond, P C;Su, Y C;Swords, W E;Brockman, K L
• 通讯作者: Brockman, K L

Panel 5: Impact of otitis media on quality of life and development.

第 5 部分：中耳炎对生活质量和发育的影响。

• 发表时间: 2020-03
• 影响因子: 1.5
• 作者: Homøe, Preben;Heidemann, Christian H;Damoiseaux, Roger Amj;Lailach, Susen;Lieu, Judith E C;Phillips, John S;Venekamp, Roderick P
• 通讯作者: Venekamp, Roderick P