INFORMATION PROCESSING IN LAMINATED NEURONAL NETWORKS

层压神经网络中的信息处理

• 批准号: 3568505
• 负责人: WALTER F HEILIGENBERG
• 金额: $ 12.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3568505
• 关键词: afferent nerve; alternatives to animals in research; animal communication behavior; brain mapping; electrophysiology; ethology; experimental brain lesion; fish; fish electric organ; fresh water environment; glutamates; hormone regulation /control mechanism; lateral line; mesencephalon; neural information processing; neural transmission; neuroanatomy; neurons; neurotransmitters; nontherapeutic iontophoresis; psychobiology; sensory feedback; serotonin; serotonin inhibitor; single cell analysis; synapses; testosterone

We plan to continue our studies of structural and functional properties of neurons and their significance for the processing of sensory information. The electrosensory system of gymnotiform fish serves as a model system for this research. We will explore relationships between the structure and function of neurons by intracellular labelling of physiologically identified cells. Using small, local iontophoretic applications of transmitters or their respective antagonists and by simultaneous extracellular recording from single neurons, we intend to study network properties that are due to the actions of specific transmitters. We will focus on three central nervous structures, the prepacemaker nucleus (PPN) of the midbrain, the pacemaker nucleus (PN) of the medulla, and the electrosensory lateral line lobe (ELL) of the hindbrain. The PPN contains two functionally different premotor systems to control the discharge frequency of the PN, one for inducing smooth changes in frequency, and one for eliciting abrupt, transient accelerations, or 'chirps'. Both forms of frequency modulations occur in response to electric signals of neighbors. Chirps, however, are exclusively produced by animals high in the rank order. Their occurrence in males is facilitated by testosterone and inhibited by serotonin. Serotonin inhibitors, such as methysergide, therefore, promote chirping. By small, local applications of agonists and antagonists to the PPN and its afferent structures, and by simultaneous recording from single neurons related to chirping, we want to identify the underlying structures as well as the mechanisms of neurotransmission in this system. The ELL is the first processing station for electrosensory information. It contains neurons with receptive fields on the body surface. The spatial and temporal dynamics of these fields are modulated by descending recurrent input. The mechanism of this modulation can be studied at the single-cell level by local application of transmitters and their antagonists.

我们计划继续研究结构和功能 神经元的特性及其对处理的重要性 感官信息。 体操运鱼的电显感觉系统 作为这项研究的模型系统。 我们将探索 神经元的结构和功能之间的关系 生理鉴定的细胞的细胞内标记。 使用 发射机及其的小型局部离子遗迹应用 各自的拮抗剂和同时进行细胞外记录 从单个神经元中，我们打算研究网络属性 是由于特定发射机的作用。 我们将重点关注三个中枢神经结构，即预科生物 中脑的核（PPN），起搏器核（PN） 髓质和电显感觉的侧向线叶（ELL） 后脑。 PPN包含两个功能上不同的前者 控制PN的放电频率的系统，一个用于 引起频率的平稳变化，一个用于突然引起的变化， 瞬态加速度或“呼叫”。 两种频率 调制是响应邻居的电信号。 然而，chir是由高中动物中的 等级顺序。 他们在男性中的发生得到了促进 睾丸激素并被5-羟色胺抑制。 5-羟色胺抑制剂， 因此，例如甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基甲基的chir。 由小的本地 激动剂和拮抗剂在PPN及其应用 传入结构，并同时记录单个 与chi有关的神经元，我们想确定基础 结构以及神经传递的机制 系统。 ELL是第一个用于电感的加工站 信息。 它包含身体上带有接收场的神经元 表面。 这些领域的空间和时间动态是 通过下降的复发输入调制。 这个机制 可以通过本地研究调制 发射器及其对手的应用。