NEURONAL STRUCTURE AND FUNCTION IN A SENSORY PROCESSOR

感觉处理器中的神经元结构和功能

• 批准号: 3404433
• 负责人: WALTER F HEILIGENBERG
• 金额: $ 10.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3404433
• 关键词: brain cell; dendrites; electron microscopy; electrophysiology; electrostimulus; histology; mesencephalon; microscopy; neural information processing; neuroanatomy; neurons; neurophysiology; nontherapeutic iontophoresis; saltwater environment; sensory feedback; sequential perception; stimulus /response

The goal is to understand how neural networks process biologically relevant sensory information and orchestrate adaptive behavioral responses. The electric sense of fish has been chosen as a model system since, in spite of its relative simplicity, it shares basic design principles with hearing and vision in higher animals. We want to continue intracellular studies of neurons in the midbrain region of weakly electric fish in order to relate physiological response properties to morphological features. Electric fish evaluate modulations in the amplitude and phase of the electric signal that results from the interference of their own electric organ discharges (EODs) with those of neighbors. Similar, but spatially varying modulations in phase and amplitude are caused by moving objects, and the detection of such objects may thus be impaired by interfering EODs. Much as in the auditory system of the owl, phase and amplitude information are coded and processed by separate neuronal channels up to the level of the midbrain. Both forms of information are then combined for the control of behavioral responses. Physiologically identified neurons are labelled by intracellular injection of either HRP or Lucifer Yellow and studied under the light microscope in order to determine their morphological features, such as laminar location of somata, dendritic organization and targets of projection. We will attempt to correlate differences in dendritic morphology with differences in functional properties, such as sensitivity to either phase or amplitude modulations, sensitivity to spatio-temporal modulations of phase and amplitude that characterize the effects of moving objects, and vulnerability of object detection to jamming. Of particular interest are: 1) Neurons of laminae 5 and 7 of the mesencephalic torus that appear to receive phase information only to the extent that their dendrites invade lamina 6, where phase information arrives from the hindbrain and where differences in the phase of signals relayed from different parts of the body surface are computed. 2) Laminar location and morphology of total neurons that detect moving objects but also are sensitive to jamming signals with particular frequency relations to the animal's own EOD.

目标是了解神经网络如何处理生物学相关 感官信息并编排适应性行为反应。 这 自从 它相对简单，它与听力和 较高动物的视力。 我们希望继续对 弱电鱼的中脑区域的神经元为了关联 生理反应对形态特征的特性。 电鱼评估调制的幅度和阶段 由他们自己的电气干扰引起的电信号 器官放电（EOD）与邻居的出院。 相似，但在空间上 相位和振幅的不同调制量是由移动对象引起的， 因此，通过干扰可能会损害此类物体的检测 EOD。 就像在猫头鹰，相位和振幅的听觉系统中一样 信息是由单独的神经元通道编码和处理的 中脑的水平。 然后将两种形式的信息合并为 控制行为反应。 生理上鉴定的神经元通过细胞内注射标记 HRP或Lucifer黄色的，并在光学显微镜下进行研究 为了确定其形态特征，例如层流位置 索马塔（Somata），树突状组织和投影目标。 我们将 试图将树突形态的差异与差异相关联 在功能特性中，例如对相位或振幅的敏感性 调制，对相位和时空调制的敏感性和 表征移动对象的影响的振幅， 对象检测到干扰的脆弱性。 特别感兴趣的是：1）Laminae 5和7的神经元 中脑圆环似乎仅接收到相位信息 其树突入侵层6的程度，相位信息 来自后脑以及信号阶段的差异 计算从身体表面的不同部位中继。 2）层流 检测移动对象但总体神经元的位置和形态 也对与特定频率关系的控制信号敏感 对动物自己的EOD。