Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related Dementias

衰老、阿尔茨海默病和相关痴呆症精准遗传学培训项目

• 批准号: 10410372
• 负责人: Gareth R Howell
• 金额: $ 24.89万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410372
• 关键词: Aging; Alzheimer' s disease related dementia; Training Programs; precision genetics

PROJECT SUMMARY/ABSTRACT The Jackson Laboratory (JAX) has been a leader in mammalian genetics research and education since its inception in 1929. JAX pioneered the development of genetic approaches toward understanding fundamental questions in mammalian development and the genetic underpinnings of human disease. JAX also has a long and illustrious track record of training postdoctoral, and more recently predoctoral scholars, to be productive researchers at the nexus of systems genetics, genomics and computational biology. To support JAX's dual mission of discovery and education, we continually strive to provide cutting-edge, unique, and highly relevant training opportunities designed to prepare all JAX trainees for successful scientific careers. An NIA T32–funded Training Program in Precision Genetics of Aging and Dementia (PGAD) would provide high-quality graduate and postdoctoral training to prepare its trainees for careers as independent investigators in universities, research institutions and the biomedical industry. It would bring together 16 highly productive and well-funded faculty mentors at the JAX Mammalian Genetics campus in Bar Harbor, ME and the JAX Genomic Medicine campus in Farmington, CT who provide a uniquely interdisciplinary, integrated and comprehensive training environment. Research foci within the context of aging and age-related disease include mammalian genetics, hematology, vascular biology, immunology, nephrology, neurology, behavior, microbiome, systems genetics, and bioinformatics. We seek to provide two slots for postdoctoral fellows, and request support for two predoctoral students. JAX participates in collaborative Ph.D. training programs with the Tufts School of Medicine, the University of Maine, and the University of Connecticut that have grown to critical mass. Specific criteria are used to admit both pre- and postdoctoral trainees into the program. Required and elective curricula have been developed to enrich the training experience. Trainees will test hypotheses regarding the genetic underpinnings of aging and disease, and will model new diagnostic and therapeutic modalities, using cutting-edge computational and mouse genetics resources uniquely available to them at JAX. Trainees will have access to focused and individualized career development opportunities, such as teaching and grant writing experiences, and will be integrated into seminars, workshops, and research interest groups. They will write external funding applications, present their findings at scientific meetings, and publish in peer-reviewed journals. Trainee evaluation will be rigorous and coupled with support for growth. The program will thus provide exceptional research opportunities in a stimulating scientific training environment and enable trainees to launch successful independent careers in biomedical research.

项目概要/摘要 杰克逊实验室 (JAX) 自成立以来一直是哺乳动物遗传学研究和教育领域的领导者 JAX 成立于 1929 年。JAX 率先开发了遗传方法来理解基本原理 哺乳动物发育和人类疾病的遗传基础的问题也由来已久。 以及培养博士后和最近的博士前学者以提高生产力的杰出记录 系统遗传学、基因组学和计算生物学领域的研究人员支持 JAX 的双重发展。 探索和教育的使命，我们不断努力提供尖端、独特和高度相关的 旨在帮助所有 JAX 学员为成功的科学事业做好准备的培训机会。 NIA T32 资助的衰老和痴呆精准遗传学培训计划 (PGAD) 将 提供高质量的研究生和博士后培训，帮助学员为独立职业生涯做好准备 来自大学、研究机构和生物医学行业的研究人员将汇聚 16 名高级研究人员。 位于缅因州巴港的 JAX 哺乳动物遗传学园区拥有富有成效且资金充足的教师导师 JAX 基因组医学校区位于康涅狄格州法明顿，提供独特的跨学科、综合和 全面的培训环境。衰老和与年龄相关的疾病的研究重点包括 哺乳动物遗传学、血液学、血管生物学、免疫学、肾脏病学、神经病学、行为学、微生物组、 系统遗传学和生物信息学。 我们寻求为博士后研究员提供两个名额，并请求为两名博士前学生提供支持。 JAX 参加与塔夫茨大学医学院的合作博士培训项目 缅因大学和康涅狄格大学已达到临界规模，用于录取这两所大学。 为丰富该计划的博士前和博士后培训生制定了必修和选修课程。 培训经验中，学员将测试有关衰老和疾病的遗传基础的假设， 并将利用尖端的计算和小鼠遗传学来模拟新的诊断和治疗方式 JAX 为学员提供了独特的资源，让他们能够获得专注且个性化的职业生涯。 发展机会，例如教学和资助写作经验，并将纳入研讨会， 他们将撰写外部资助申请，并在以下网站上展示他们的发现。 科学会议，并在同行评审期刊上发表论文，对学员的评估将是严格的，并加上 因此，该计划将为刺激科学发展提供特殊的研究机会。 培训环境，使学员能够在生物医学研究方面成功地开展独立职业生涯。