Development of the next-generation intelligent medical packaging - using advanced micro electronics, Cloud-based IoT and big data technology to tackle medical non-adherence.

开发下一代智能医疗包装——利用先进的微电子、基于云的物联网和大数据技术来解决医疗不依从问题。

• 批准号: 49750
• 金额: $ 43.7万
• 依托单位: ORIGIN PACKAGING LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=49750
• 关键词: Development; next; generation; intelligent; medical

**Problem**Medical adherence is a global epidemic which needs to be addressed - from elongating recovery times and waste, to helping viruses develop resistance to drugs and the Opioid crisis - the consequences of patients not correctly taking their medication are extremely damaging and costly.The ultimate cost is loss of life; in the EU alone an estimated 200,000 (125,000 in the US) people die prematurely as a result of not following their medication regime properly.The financial costs are staggering also, globally, medical non-adherence costs healthcare providers £487bn [(Source- Healthprize)][0]. In the UK the [Adherence-Lets Take Care][1] of it campaign states non-adherence is draining a cash-strapped NHS £500m/annum. Money that could be used to hire extra staff, fund vital surgery or cover some of the costs of life-saving cancer therapies.**Origin's Solution**Origin Pharma's vision is to create "next-generation intelligent blister packs"- the concept is to wrap medication blister packaging with our Digital Wallet (created via Patented technology), the Digital Wallet will communicate with our cloud-based data platform as and when blister cavities are opened.The data will then be utilised by our Patient Engagement & Data platform to track and trace the interaction between the patient and the meds, 24/7\. This time critical information will allow HealthCare providers to engage with patients proactively to ensure medication adherence and offer many wider benefits to the industry and society(see outputs).**Project Focus**Utilising advanced micro electronics, Cloud-based IoT and big data technology, we will create a prototype TRL5 digital wallet (miniaturised/agile/scalable) that will be sealed (tamper evident) around a blister pack, transmitting real time data notifications to an industry standard AWS cloud based data platform.The prototype will then be trialed via an NHS led clinical trial to test the robustness and positive potential of the innovation; create proprietary data and demonstrate technical feasibility to the NHS/healthcare providers.**Outputs*** A TRL6 (post trial) Digital Wallet technology-modular, agile, sustainable* Independent validation by NHS* Reduction of loss of life to vulnerable patient groups* Reduction of clinical trial patient attrition from ~30% to <5% (improve time to market\> saving lives)* Reduction in financial loss of medical non-adherence - currently £487bn globally* Improved industry-wide insight into medication adherence via proprietary-data generation* Waste prevention(Environmental)- In Wales, more than 250 tons of out-of-date, surplus and redundant medicines each year* Reduce the burden on loved ones/cost of assisted adherence[0]: https://healthprize.com/blog/medication-adherence-pharmas-637-billion-opportunity/[1]: http://www.letstakecareofit.com/wp-content/uploads/2015/10/The-True-Cost-of-Medication-Non-Adherence-Report.pdf

**问题**医疗依从性是一个需要解决的全球流行病 - 从延长恢复时间和浪费，到帮助病毒产生耐药性和阿片类药物危机 - 患者不正确服药的后果是极具破坏性和昂贵的最终的代价是生命损失；仅在欧盟，估计就有 200,000 人（美国为 125,000 人）因未正确遵循用药方案而过早死亡。在全球范围内，医疗费用也是惊人的不遵守规定给医疗保健提供者造成了 4870 亿英镑的损失[（来源- Healthprize）][0]。在英国，该运动的[遵守-让我们小心][1] 指出，不遵守规定正在耗尽现金短缺的 NHS 5 亿英镑/。每年的资金可用于雇用额外的员工、资助重要手术或支付挽救生命的癌症治疗的部分费用。**Origin 的解决方案**Origin Pharma 的愿景是创造“下一代智能泡罩包装”-概念是用我们的数字钱包（通过专利技术创建）包裹药物泡罩包装，当泡罩腔打开时，数字钱包将与我们基于云的数据平台进行通信。数据然后，我们的患者参与和数据平台将利用它来跟踪患者与药物之间的互动，24/7\。这次关键信息将允许医疗保健提供者主动与患者互动确保用药依从性，并为行业和社会提供更广泛的利益（见成果）。**项目重点**利用先进的微电子、基于云的物联网和大数据技术，我们将创建一个原型TRL5数字钱包（小型/敏捷/可扩展）将被密封（防篡改）在泡罩包装周围，将实时数据通知传输到基于行业标准 AWS 云的数据平台。然后，该原型将通过 NHS 主导的临床试验进行试验，以测试其稳健性和积极潜力这创新；创建专有数据并向 NHS/医疗保健提供者展示技术可行性。**输出*** TRL6（试验后）数字钱包技术-模块化、敏捷、可持续* NHS 独立验证* 减少弱势群体的生命损失患者群体* 将临床试验患者流失率从约 30% 减少至 <5%（缩短上市时间\> 挽救生命）* 减少医疗不依从造成的经济损失 - 目前全球为 4,870 亿英镑* 提高全行业对药物的洞察力通过专有数据生成* 废物预防（环境）- 在威尔士，每年有超过 250 吨过期、过剩和多余的药物* 减轻亲人的负担/辅助依从性的成本[0]：https： //healthprize.com/blog/medication-adherence-pharmas-637-billion-opportunity/[1]： http://www.letstakecareofit.com/wp-content/uploads/2015/10/The-True-Cost-of-Meduction-Non-Adherence-Report.pdf