CALORIC RESTRICTION AND CARDIOVASCULAR AGING

热量限制和心血管衰老

• 批准号: 3068537
• 负责人: William T. Cefalu
• 金额: $ 7.83万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3068537
• 关键词: Macaca fascicularis; adipose tissue; aging; artery; atherosclerosis; atherosclerotic plaque; blood chemistry; blood pressure; body composition; caloric dietary content; cardiovascular disorder epidemiology; cell wall; cholesterol; collagen; dietary lipid; disease /disorder model; disease /disorder proneness /risk; electrocardiography; fats; glucose tolerance test; glycation; insulin sensitivity /resistance; longitudinal animal study; nonhuman therapy evaluation; nutrition related tag; reducing diet; skin

Caloric restriction has been shown in numerous studies in rodents to extend the maximal life span, retard age-associated physiological changes and delay or prevent most age associated disease. If these findings are to be extrapolated to human beings, it will first be necessary to test varying dietary regimens in some higher species and evaluate the effect on an age-related disease process, particularly as it relates to human health. As such, age related disease such as atherosclerosis would be a valuable end point to study. To diminish atherosclerosis, the caloric restriction should alter pathogenic mechanisms contributing to the disease process. Therefore, the proposed research will evaluate a well characterized non -human primate model for human atherosclerosis and study dietary intervention in the form of caloric restriction compared to unrestricted diet with equivalent cholesterol content. We will evaluate for changes secondary to the dietary restriction on insulin resistance, arterial collagen glycation/advanced glycation, and adipose distribution, all of which have been strongly implicated in contributing to cardiovascular disease. The changes in our parameters secondary to dietary intervention, will be related to changes in atherosclerosis assessed at study completion.

大量针对啮齿动物的研究表明，热量限制可以 延长最大寿命，延缓与年龄相关的生理变化 延缓或预防大多数与年龄相关的疾病。 如果这些发现是 要将其推广到人类，首先需要进行测试 在一些高等物种中改变饮食方案并评估其效果 与年龄相关的疾病过程，特别是与人类有关的疾病过程 健康。 因此，动脉粥样硬化等与年龄相关的疾病将是 有价值的研究终点。 为了减少动脉粥样硬化，热量 限制应该改变致病机制，导致 疾病过程。 因此，拟议的研究将评估良好 表征人类动脉粥样硬化的非人类灵长类动物模型和 研究以热量限制形式进行的饮食干预与 不限制饮食，胆固醇含量相当。 我们将评估 对于胰岛素抵抗饮食限制继发的变化， 动脉胶原糖化/高级糖化和脂肪分布， 所有这些都与促进 心血管疾病。 我们的参数变化继发于 饮食干预，会与动脉粥样硬化的变化有关 研究完成时进行评估。