CORE B (Molecular Pathology Core)

CORE B（分子病理学核心）

基本信息

批准号：
10407749
负责人：
Oliver Gene McDonald
金额：
$ 13.24万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-08 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10407749
关键词：
Animals Barrett Esophagus Basic Science Biostatistics Core Chemicals Clinical Research Collaborations Collection Comprehensive Cancer Center Consultations Custom Data Diagnostic Doctor of Philosophy Dysplasia Ensure Esophageal Adenocarcinoma Evaluation Experimental Pathology Fee-for-Service Plans Genetic Transcription Gold Histology Human In Situ Individual Infrastructure Laboratories Lesion Measures Microscopic Morphology Mus Operative Surgical Procedures Pathologist Pathology Patients Process Quality Control Research Research Personnel Resource Sharing Resources Sampling Services Slide Specimen Staging Stains Structure Supervision System Testing Tissue Procurements Tissue Sample Tissues Universities Work animal tissue anticancer research base biobank clinically relevant cost effective experience gastrointestinal human tissue in vivo interest molecular pathology mouse model neoplastic protein expression quality assurance tissue resource tumorigenesis

项目摘要

Abstract/Summary: The Molecular Pathology Core will be located at the University of Miami under the direct supervision of Dr. Oliver McDonald, MD, Ph.D., with collaborative support from Dr. Ladan Fazlollahi, MD, MPH at Columbia University. This Core provides several essential services to P01 investigators. The Molecular Pathology Core interfaces with existing infrastructure at the University of Miami to coordinate the collection of high quality tissue specimens (human and animal) so that an experienced gastrointestinal pathologist can process them into slide-based formats (H&E stains, TMAs, specialized chemical stains, immunohistochemical stains) that are suitable for histopathologic microscopic evaluation. The Core also annotates, stores, and tracks tissue biospecimens as they are collected and processed. Most importantly, the Core provides expert gastrointestinal pathology consultation and diagnostic slide review, including H&E morphology, special stain interpretation, and immunohistochemical (IHC) evaluation. These basic Core services are required for successful execution of P01 projects, all of which require in-depth histopathologic characterization of Barrett’s Esophagus (BE) and esophageal adenocarcinoma (EAC). The grading of BE-associated glandular dysplasia, grading and staging esophageal adenocarcinoma, evaluating of in situ protein expression in these lesions, and implementating of quantitative scoring systems are amenable to statistical tests of significance in collaboration with the Biostatistics Core.

摘要/总结：分子病理学核心将设在迈阿密大学，由 Dr. 直接监督。 Oliver McDonald，医学博士、哲学博士，并得到哥伦比亚大学医学博士、公共卫生硕士 Ladan Fazlollahi 博士的合作支持大学。该核心为 P01 分子病理学核心研究人员提供多项基本服务。与迈阿密大学现有基础设施接口，以协调高质量的收集组织标本（人类和动物），以便经验丰富的胃肠道病理学家可以处理它们成基于载玻片的格式（H&E 染色剂、TMA、专用化学染色剂、免疫组织化学染色剂）适用于组织病理学显微镜评估。Core 还可以注释、存储和跟踪组织。最重要的是，Core 提供了专业的胃肠道技术。病理学咨询和诊断幻灯片审查，包括 H&E 形态、特殊染色解释和免疫组织化学 (IHC) 评估需要这些基本的核心服务。 P01 项目，所有这些项目都需要对巴雷特食管 (BE) 进行深入的组织病理学表征 BE 相关腺体发育不良的分级、分级和分期。食管腺癌，评估这些病变中的原位蛋白表达，并实施定量评分系统可以与以下机构合作进行显着性统计测试生物统计学核心。