Operant Behavioral Instrument for Measuring Trigeminal Neuropathic Pain in Rodent

用于测量啮齿动物三叉神经病理性疼痛的操作行为仪器

基本信息

批准号：
8080853
负责人：
RICHARD H MILLS
金额：
$ 56.97万
依托单位：
STOELTING COMPANY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-15 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8080853
关键词：
Absence of pain sensation Address Advanced Development Affect American Analgesics Animal Model Animal Testing Animals Automation Behavior Behavioral Behavioral Assay Biological Assay Boxing Brain Stem Clinical Treatment Collaborations Computer software Conflict (Psychology)Custom Data Development Devices Engineering Epidemic Evaluation Failure Feedback Goals Grant Grooming Institution Lead Light Link Manufactured Supplies Marketing Measurement Measures Mediating Methods Mind Modeling Modification Molecular Mus Nature Nociception Outcome Output Pain Pain Disorder Pain Measurement Pain Research Pharmaceutical Preparations Pharmacologic Substance Phase Process Public Health Rattus Reflex action Research Research Personnel Response to stimulus physiology Rewards Rodent Running Scientist Sensory Series Societies Software Engineering Stimulus System Tail Testing Time Training Translating Translations Trigeminal System Work base behavior test bench to bedside chronic pain clinical care clinical practice clinically relevant commercialization cost data acquisition design experience flexibility improved in vivo innovation instrument meetings novel painful neuropathy programs public health relevance research study response software systems success translational approach treatment strategy tv watching user-friendly

项目摘要

DESCRIPTION (provided by applicant): Chronic pain remains a major burden on society, significantly affecting millions of people and costing the populace billions annually. Despite major advances made to our understanding of pain, very few new therapies have successfully translated to clinical care. A particular shortfall in this translation is the lack of a high-throughput, commercially available in vivo assay. To address this deficit, we are refining our novel operant behavioral system for assessing pain in rodents. The central hypothesis is that operant assays can provide a sensitive, reliable, and clinically relevant way to evaluate sensory and nociceptive processing. Three specific aims will be investigated: (1) to evaluate a peltier thermal-stimulus system for operant pain testing; (2) to develop and optimize the software control of the operant pain-testing system; and (3) to evaluate multiple-linked operant behavior box units. We will achieve these aims using the innovative operant system that we developed in the Phase I grant, which assesses thermal pain in a reward-conflict paradigm. The rationale for the proposed research is that a software-driven, in vivo system will allow for a high- throughput approach for completing behavioral pain and analgesic studies. We are developing and commercializing an innovative product that will meet these needs. We are particularly well suited to complete this work, given the pairing of Stoelting Company's expertise in developing the product and Drs. Neubert and Caudle's pain-research experience. We completed all of the Phase I proposal's milestones, and this Phase II grant will build on our success. This product line could significantly reduce the time for new pain-relieving therapies to be screened and evaluated, greatly enhancing the opportunity for discovery of a superior analgesic. PUBLIC HEALTH RELEVANCE: Successful development of this reliable, high-throughput operant pain-assessment device would lead to commercial success through both academic and pharmaceutical institutions. This commercialization would create a method to more quickly convey new viable pain treatments from bench to bedside; if this helped accelerate even one new effective analgesic therapy, there would be tremendous societal benefit. This project will provide a key step in reaching this goal of advancing translational pain research.

描述（由申请人提供）：慢性疼痛仍然是社会的重大负担，严重影响了数百万的人，每年损失数十亿人口。尽管我们对疼痛的理解取得了重大进展，但很少有新的疗法成功地转化为临床护理。这种翻译中的特殊缺口是缺乏体内测定中的高通量，商业上可用的。为了解决这种赤字，我们正在完善我们的新型操作行为系统，以评估啮齿动物的疼痛。中心假设是操作分析可以提供一种敏感，可靠且与临床相关的方法来评估感觉和伤害性处理。将研究三个具体目标：（1）评估用于操作疼痛测试的毛皮尔热刺激系统；（2）开发和优化操作疼痛测试系统的软件控制；（3）评估多连连接的操作行为框单元。我们将使用我们在I阶段赠款中开发的创新操作系统实现这些目标，该系统评估了奖励冲突范式中的热痛。拟议的研究的理由是，由软件驱动的体内系统将允许采用高通量方法来完成行为疼痛和止痛研究。我们正在开发和商业化可以满足这些需求的创新产品。考虑到Stoelting Company在开发产品和DRS方面的专业知识的配对，我们特别适合完成这项工作。 Neubert和Caudle的疼痛研究经验。我们完成了第一阶段提案的所有里程碑，这一第二阶段赠款将基于我们的成功。该产品线可能会大大减少对新的缓解疼痛疗法进行筛查和评估的时间，从而大大增加了发现出色镇痛药的机会。公共卫生相关性：成功开发这种可靠的高通量操作人员疼痛评估设备将通过学术和制药机构带来商业成功。这种商业化将创造一种方法，以更快地传达从长凳到床边的新可行疼痛治疗的方法。如果这有助于加速一种新的有效的镇痛疗法，那么社会利益将会有很大的收益。该项目将为实现转化疼痛研究的目标提供关键步骤。