Alzheimer's Disease Research Center

阿尔茨海默病研究中心

• 批准号: 10410047
• 负责人: SCOTT A SMALL
• 金额: $ 13.21万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410047
• 关键词: Address; Advisory Committees; Alzheimer' s Disease; Awareness; Biological; Biological Markers; Cell physiology; Cholesterol Homeostasis; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Committee Members; Communities; Data; Discipline; Disease; Early Diagnosis; Enrollment; Environment; Fostering; Genes; Genetic; Genomics; Goals; Immune response; Infrastructure; Institution; Intervention; Learning Module; Mission; Nerve Degeneration; Observational Study; Participant; Pathogenesis; Pathogenicity; Pathology; Pathway interactions; Patient Care; Patient Recruitments; Patients; Pharmaceutical Preparations; Prevention; Research; Research Infrastructure; Research Personnel; Resources; Therapeutic Trials; Time; Training; United States National Institutes of Health; Universities; Vision; Work; amyloid pathology; base; career; community organizations; data management; education research; interdisciplinary collaboration; interest; neuroimaging; neuroimmunology; neuropathology; outreach; patient outreach; phenomenological models; prevent; programs; ranpirnase; recruit; success; tau Proteins; tool; trafficking; translational scientist

The recent pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or coronavirus disease (COVID-19), has disrupted much in the world. New York City and Columbia University Irving Medical Center have been the hospital at the COVID national and international epicenter. The psychosocial and functional implications of COVID-19 on our local population are myriad. The population affected by mild cognitive impairment and dementia (including Alzheimer’s Disease (AD) and Alzheimer Disease-related dementias (ADRD)) faces high case fatality rates and major disruptions in care following necessary social distancing polices for high risk persons. These changes have imposed new and unexpected personal and professional caregiver strains. Specifically, the following have occurred in the population for whom our center provides care: a) the loss of potential direct contact with professional caregivers due to their own social distancing requirements, new person caregiving responsibilities, personal illnesses b) limited excursions in the local environment out of concerns, for contracting COVID-19, and c) closure of myriad social day activities, both formal and informal. As a result, during periods of social isolation, persons with dementia are largely bound to their homes, confused by the chaos, and perceive and express the stress their family members experience. Moreover, many of these same family caregivers must balance remote work responsibilities and family caregiving, often within the same home. Unfortunately, some of these circumstances are untenable and have led to illness, hospitalization, and death of some of our patients and research participants, as well as their family members. This proposal will explore the experiences, knowledge, attitudes, healthcare-seeking behaviors, and psychosocial support related to the NYC COVID-19 epidemic, particularly among adults with normal cognition being followed in the ADRC as well as care partners for those persons with pathological cognitive aging, as well as socioeconomic determinants. It is hypothesized that many adults will have experienced adverse outcomes, been impacted in their personal and professional caregiver expectations, and variably demonstrate COVID-19 specific health seeking behaviors, as well as had care impacted, particularly those of advancing age or caring for others with advancing age, in ethnic minorities, and disadvantaged socioeconomic groups. Better understanding health-seeking behaviors and determinants during and after the local COVID-19 epidemic has potential implications both locally and potentially globally wherever community spread is growing. An effective survey instrument, with modules purposefully designed to be capture multigenerational effects may be relevant to some time to come, until the current pandemic has passed, as well as future pandemics or other emergencies which restrict social engagement and population movement.

最近流行的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 或冠状病毒病 （COVID-19）给纽约市和哥伦比亚大学欧文医学中心带来了很大的影响。 是新冠疫情全国和国际震中的医院。 COVID-19 对我们当地人口的影响是多方面的。 损伤和痴呆（包括阿尔茨海默病 (AD) 和阿尔茨海默病相关痴呆 （ADRD））在采取必要的社交距离政策后面临高病死率和严重的护理中断 对于高风险人群来说，这些变化带来了新的、意想不到的个人和专业护理人员。 具体来说，在我们中心提供护理的人群中发生了以下情况： a）由于专业护理人员自身的社交距离而失去与专业护理人员的潜在直接接触 要求、新人护理责任、个人疾病 b) 出于对感染 COVID-19 的担忧，在当地环境中进行有限的游览，以及 c) 结束各种正式和非正式的社交日活动。 因此，在社会隔离期间，痴呆症患者大部分都呆在家里， 因混乱而感到困惑，并感知并表达家人所经历的压力。 这些家庭照顾者必须平衡远程工作责任和家庭照顾，通常在 不幸的是，其中一些情况是无法维持的，并导致了疾病， 我们的一些患者和研究参与者及其家人住院、死亡。 该提案将探讨经验、知识、态度、就医行为和 与纽约市 COVID-19 流行病相关的社会心理支持，尤其是认知正常的成年人 ADRC 以及病理性认知老化患者的护理合作伙伴也对其进行跟踪 作为社会经济决定因素，许多成年人都会经历不良后果， 他们的个人和专业护理人员期望受到影响，并且表现出不同程度的 COVID-19 症状 特定的求医行为以及护理受到影响，特别是那些年老或护理行为 对于其他年龄较大的人、少数民族和社会经济弱势群体。 更好地了解当地 COVID-19 期间和之后的求医行为和决定因素 无论社区传播在哪里，流行病都会对当地和全球产生潜在影响。 一个有效的调查工具，其模块专门设计用于捕捉多代效应，可能会 与未来某个时间相关，直到当前的大流行病过去，以及未来的大流行病或其他 限制社会参与和人口流动的紧急情况。