Administrative Core

行政核心

• 批准号: 10413093
• 负责人: SCOTT A SMALL
• 金额: $ 77.47万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413093
• 关键词: Administrator; Advisory Committees; Advocacy; Alzheimer' s Disease; Alzheimer' s disease therapeutic; Awareness; Bioethics; Biological; Charge; Cholesterol Homeostasis; Collaborations; Data; Development; Disease; Environment; Exercise; Fostering; Funding; Genetic; Goals; Immune response; Institution; Intervention; Leadership; Mind; Mission; Monitor; National Institute on Aging; Neurologic; Neuropsychology; Outreach Research; Participant; Pathogenicity; Pathway interactions; Patient Care; Patient Recruitments; Patients; Process; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Time; Training; Universities; Vision; Work; career; cell repository; community center; cooperative study; education research; flexibility; high standard; imaging biomarker; innovative technologies; interdisciplinary collaboration; meetings; outreach; prevent; programs; ranpirnase; recruit; trafficking

ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The general goals of this application for a new P30 ADRC at Columbia University include creating an infrastructure for research on AD and related disorders, fostering interdisciplinary collaborations across many departments, providing a rich training environment, and supporting outreach and patient recruitment. More globally, the goals of our Center will extend to include participation in national coordinating efforts, working with the national network of AD centers, and working with the National Institute on Aging and other organizations in their advocacy efforts. Embedded within the general goals, the Center’s thematic goal will be on better understanding the three biological pathways now considered to act as pathogenic drivers in AD: An ‘immune response’ pathway, a ‘cholesterol metabolism’ pathway, and an ‘endosomal trafficking’ pathway. Both the general and thematic goals were conceived with NAPA’s ambitious milestones in mind-- to prevent or treat AD and related disorders, to optimize patient care, to extend patient support, and to enhance public awareness. The Administrative Core will act as the executive governing body of the Center that, with the guidance of its various committees, will provide the vision and leadership necessary to achieve the Center’s general and thematic goals. The Core will implement this vision by exercising managerial oversight over all aspects of the Center, which includes assuring the highest standards of scientific and bioethical conduct, and a judicious use of resources and funds. More specifically, the Core will achieve its goals by: Directing regular meeting with the Center’s Core leaders and administrators; working with an external and internal advisory committee; assuring delivery of data and biospecimens to investigators and to national consortia; and assuring and enhancing the Center’s community outreach and research education mission.

行政核心项目摘要/摘要 哥伦比亚大学新 P30 ADRC 申请的总体目标包括创建一个 AD 及相关疾病的研究基础设施，促进跨学科合作 部门，提供丰富的培训环境，并支持外展和患者招募更多。 在全球范围内，我们中心的目标将扩展到包括参与国家协调工作，与 国家 AD 中心网络，并与国家老龄化研究所和其他组织合作 将他们的宣传工作嵌入到总体目标中，中心的主题目标将会更好。 了解目前被认为是 AD 致病驱动因素的三种生物途径：“免疫 反应”途径、“胆固醇代谢”途径和“内体运输”途径。 总体目标和主题目标是根据 NAPA 雄心勃勃的里程碑制定的——预防或治疗 AD 和相关疾病，以优化患者护理、扩大患者支持并提高公众意识。 行政核心将作为中心的执行管理机构，在其指导下 各个委员会，将提供必要的远见和领导力，以实现中心的总体和 核心将通过对各方面进行管理监督来实现这一愿景。 中心，其中包括确保最高标准的科学和生物伦理行为以及明智的使用 的资源和资金。 更具体地说，核心将通过以下方式实现其目标： 指导与中心核心领导人的定期会议 和管理人员；与外部和内部咨询委员会合作，确保数据的交付； 向研究人员和国家联盟提供生物样本，并确保和加强中心的社区； 外展和研究教育任务。