“Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment

☀产前隔离和不确定性压力影响母亲心理健康和儿童神经发育的重叠和离散途径

• 批准号: 10406163
• 负责人: Natalie Hiromi Brito
• 金额: $ 76.56万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10406163
• 关键词: Address; Affect; Age; Allopregnanolone; Animals; Architecture; Area; Attention; Award; Behavior; Behavior assessment; Behavioral; Bioenergetics; Biological; Biology; Biophysics; Brain; COVID-19; COVID-19 pandemic; Child; Child Development; Collection; Communicable Diseases; Data Collection; Development; Diffusion; Disasters; Economics; Electrocardiogram; Electroencephalogram; Endocrine; Enrollment; Environment; Etiology; Event; Fatty Acids; Fiber; Foundations; Glucose; Goals; Health; Height; Home environment; Hormonal; Hour; Human; Human Development; Hydrocortisone; Infant; Inflammation; Inflammatory; Investigation; Knowledge; Learning; Leptin; Life; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Medical; Mental Health; Modality; Morbidity - disease rate; Mothers; Movement; Myelin; Neurocognitive; New York City; Outcome; Parents; Pathway interactions; Perinatal; Persons; Phase; Physiological; Play; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Prevalence; Psychopathology; Psychosocial Stress; Questionnaires; Relaxation; Research; Risk; Role; Sinus Arrhythmia; Social Environment; Social isolation; Societies; Stress; Sum; Supervision; Surveys; System; Testing; Time; Uncertainty; United States National Institutes of Health; Variant; Woman; Work; arm; awake; base; care providers; cohort; course development; experience; family support; follow-up; imaging approach; innovation; machine learning algorithm; multimodal neuroimaging; multimodality; neurobehavior; neurobehavioral; neurobehavioral disorder; neurodevelopment; new technology; offspring; pandemic disease; physical conditioning; postnatal; preclinical study; pregnant; prenatal; prospective; psychobiologic; psychobiology; psychologic; public health relevance; recruit; remote sensing; respiratory; response; restraint; sensor technology; serial imaging; sound; stressor; tool

PROJECT SUMMARY The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is exerting wide-spread impact on the lives of expectant mothers around the world. Particularly salient pandemic- related stressors that are being experienced by pregnant women are social isolation and uncertainty stress. There is ample physiological and behavioral literature showing that social isolation and uncertainty stress affect typical human and animal psychobiological functioning, but there is an absence of knowledge about how these conditions might impact the physical and psychological health of a pregnant woman, and what the consequences of those changes might be for her developing child. The central objective of this proposal is to build foundational knowledge about the effects of prenatal social isolation and uncertainty stress on maternal psychobiology and infant neurobehavior. We will explore several candidate physiological systems in the mother to elucidate mechanisms that underlie associations between maternal stressors and child outcomes. To achieve these goals, we will recruit 200 women from a large New York City cohort established at the height of the pandemic into a prospective, longitudinal study that will include pre- and postnatal biospecimen collection and child neurobehavioral assessments at 6-, 12- and 24 months. Multi-modal neuroimaging strategies, including infant EEG and quantitative MRI, and innovative remote biophysical data collection strategies will be employed. The primary aims of this project are to (i) examine the impact of prenatal social isolation and uncertainty stress on maternal biology and postnatal mental health; (ii) evaluate the influence of maternal prenatal social isolation and uncertainty stress on infant neurobehavioral development; and (iii) examine the role of prenatal social isolation and uncertainty stress on mother-infant bi-directional interactions. We will thus be able to meaningfully evaluate whether, and how, prenatal social isolation and uncertainty stress modify maternal biology and affect, and the neurobehavioral consequences of those impacts on infants. Such work would constitute a substantial advance in our understanding of the longitudinal effects of prenatal psychosocial stress exposures, the underlying mechanistic pathways, and the origins of child neurobehavioral disorders.

项目概要 产前时期被认为是人类发育中最敏感的阶段之一。发生的事件 妊娠期间可以改变发育过程并产生持久影响。目前，新冠肺炎 (COVID-19) 疫情正 对世界各地孕妇的生活产生广泛影响。疫情尤为突出—— 孕妇所经历的相关压力源是社会孤立和不确定性压力。 有大量的生理和行为文献表明，社会孤立和不确定性压力会影响 典型的人类和动物心理生物学功能，但缺乏关于这些功能如何发挥作用的知识。 哪些情况可能会影响孕妇的身心健康？ 这些变化可能会对她正在发育的孩子产生影响。该提案的中心目标是 建立有关产前社会隔离和不确定性压力对母亲影响的基础知识 心理生物学和婴儿神经行为。我们将探索几个候选生理系统 母亲阐明母亲压力源与儿童结局之间关联的机制。 为了实现这些目标，我们将从纽约市的一个大型队列中招募 200 名女性 将这一流行病纳入一项前瞻性纵向研究，其中包括产前和产后生物样本 6、12 和 24 个月时的收集和儿童神经行为评估。多模态神经影像 策略，包括婴儿脑电图和定量 MRI，以及创新的远程生物物理数据收集 将采用策略。该项目的主要目的是 (i) 研究产前社交活动的影响 隔离和不确定性压力对孕产妇生物学和产后心理健康造成影响； (ii) 评估影响 母亲产前社会隔离和不确定性压力对婴儿神经行为发育的影响； (三) 研究产前社会隔离和不确定性压力对母婴双向互动的作用。 因此，我们将能够有意义地评估产前社会隔离和不确定性是否以及如何影响 压力会改变母亲的生物学和影响，以及这些影响对婴儿的神经行为后果。 这些工作将极大地促进我们对产前妊娠纵向影响的理解。 心理社会压力暴露、潜在的机制途径以及儿童神经行为的起源 失调。