Clinical Pediatric Research Training for the Fetal-Neonatal Brain

胎儿-新生儿大脑的临床儿科研究培训

• 批准号: 10393548
• 负责人: ADRE Jacques DU PLESSIS
• 金额: $ 34.45万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393548
• 关键词: Clinical; Pediatric Research; Research Training; fetal; neonatal brain

SUMMARY/ABSTRACT The rationale for this application is to fill the current void in clinical research training for the emerging discipline of fetal-neonatal neurology. The rapid development of the fetal and newborn brain, and the unique genetic and environmental factors that threaten such development, make the immature brain distinctly different from that of even older infants. Yet, despite the growing recognition of the lifespan impact of events during this critical period, clinical and research training in neurology of the fetus and newborn remains remarkably inadequate. The objective of this program is to provide multidisciplinary training in clinical neuroscience research within the context of the fetal/neonatal environment. Trainees will enter a two to three year program with an MD, DO, PhD or MD/PhD. The primary site for the Clinical Research Training Program for the Fetal Neonatal Brain is the Children’s National Health System (CNHS) in Washington, D.C. Training will be provided in the responsible conduct of research, the acquisition of high-throughput ‘bedside’ clinical data in the NICU, and the processing and analysis of data using sophisticated neurodiagnostic techniques. Two NIH-funded Principal Investigators with complementary clinical and research expertise will be supported by neuroscience preceptors (neurology, neuroradiology, neurogenetics), and mentors/subject matter experts from neonatal intensive care, neonatal cardiac surgery, and clinical research methodology. The mentorship team is assembled from Children’s National and the George Washington University (GWU). Children’s National is well positioned to lead this program, based on (i) its strengths in translational and clinical research, and mentorship in the central areas of inquiry; (ii) its formal funded research collaboration (CNICA Program) with Inova Women’s and Children’s Hospitals, and (iii) the strength of its fetal and neonatal medicine programs. Each trainee will develop special expertise in an advanced neurodiagnostic technique, complete a Master’s of Science in Health Sciences Clinical (MSHS) at GWU or equivalent, and will design and implement a research project overseen by her/his mentorship team. By graduation, the trainee will have presented his/her data to at least one national research meeting, submitted one or more manuscripts to external peer-reviewed journals, and have a well-formulated plan for a grant application. The program will prepare trainees with the skills and expertise to develop into future leaders in the effort to reduce and prevent brain injury in the fetus and newborn infant.

摘要/摘要 此应用程序的基本原理是填补新兴学科临床研究培训中当前的空白 胎儿-新生儿神经病学 胎儿和新生儿大脑的快速发育，以及独特的遗传和发育特征。 威胁这种发育的环境因素使未成熟的大脑与正常人的大脑明显不同 然而，尽管人们越来越认识到这一关键时期的事件对寿命的影响。 在此期间，胎儿和新生儿神经病学的临床和研究培训仍然严重不足。 该计划的目标是在临床神经科学研究领域提供多学科培训 受训者将进入一个为期两到三年的项目，其中包括医学博士、DO、 胎儿新生儿大脑临床研究培训计划的主要地点。 是位于华盛顿特区的儿童国家卫生系统 (CNHS)。培训将在 负责任地进行研究，在 NICU 中获取高通量“床边”临床数据，以及 使用复杂的神经诊断技术处理和分析数据 两位 NIH 资助的校长。 具有互补临床和研究专业知识的研究人员将得到神经科学的支持 来自新生儿的导师（神经病学、神经放射学、神经遗传学）和导师/主题专家 重症监护、新生儿心脏手术和临床研究方法学是导师团队。 由国立儿童医院和乔治华盛顿大学 (GWU) 组成的机构非常好。 定位于领导该计划，基于（i）其在转化和临床研究以及指导方面的优势 在核心研究领域；(ii) 与 Inova 的正式资助研究合作（CNICA 计划） 妇女儿童医院，以及 (iii) 其胎儿和新生儿医学项目的实力。 实习生将发展先进神经诊断技术的特殊专业知识，完成硕士学位 乔治华盛顿大学健康科学临床科学 (MSHS) 或同等学历，并将设计和实施 由她/他的导师团队监督的研究项目 毕业时，受训者将展示他/她的研究项目。 向至少一次国家研究会议提供数据，向外部同行评审提交一份或多份手稿 期刊，并制定完善的资助申请计划 该计划将为学员做好准备 培养成为未来领导者的技能和专业知识，努力减少和预防胎儿脑损伤 和新生婴儿。