Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

少数族裔的饮食相关炎症和肾功能下降

• 批准号: 10392475
• 负责人: Tanya Johns
• 金额: $ 18.8万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392475
• 关键词: Address; Advisory Committees; Affect; African American; African American population; Albuminuria; Alzheimer' s disease risk; American; Ancillary Study; Anti-Inflammatory Agents; Award; Benchmarking; Biological Markers; Biometry; Chronic; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Communities; Comparative Effectiveness Research; Cross-Sectional Studies; Cultural Diversity; Data; Data Analyses; Development; Diet; Dietary Intervention; Dietary Practices; Disease Progression; Enrollment; Environment; Ethnic group; European; Experimental Models; Feasibility Studies; Food Preferences; Funding; Goals; Health; Health Disparities Research; Healthy Eating; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Impaired cognition; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Jackson Heart Study; Journals; Kidney; Kidney Diseases; Knowledge; Longitudinal Studies; Measures; Mediating; Medical center; Medicine; Mediterranean Diet; Mentors; Mentorship; Minority Groups; Morbidity - disease rate; Nephrology; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Oxidative Stress; Participant; Pattern; Pilot Projects; Population Heterogeneity; Prevention; Publications; Randomized Controlled Trials; Reduce health disparities; Renal function; Research; Research Personnel; Research Proposals; Research Training; Resources; Risk; Risk Factors; TNF gene; Testing; Text; Training; United States National Institutes of Health; Ursidae Family; Woman; Women' s Health; Work; Writing; acceptability and feasibility; arm; career; career development; clinical trial implementation; cohort; college; comparative effectiveness study; cost; design; dietary; dietary approach; disorder risk; endothelial dysfunction; ethnic minority; experience; functional decline; good diet; health disparity; high risk; improved; indexing; intervention effect; lifestyle factors; low socioeconomic status; meetings; member; mortality; multidisciplinary; novel; nutrition; nutritional epidemiology; programs; racial and ethnic; recruit; renal damage; research and development; skills; systemic inflammatory response; therapeutic target; treatment arm; western diet

PROJECT SUMMARY/ ABSTRACT: The primary purpose of this proposal is to provide Tanya Johns, MD, MHS, a clinical investigator in the Department of Medicine (Division of Nephrology) at Albert Einstein College of Medicine/ Montefiore Medical Center, with the skills and mentored guidance necessary to develop into an independent clinical researcher and a nationally recognized expert focused on reducing health disparities in chronic kidney disease (CKD). Dr. Johns’ research proposal examines the relationship between dietary patterns and inflammation, and its association with kidney function decline in racial/ethnic minorities. Growing evidence suggests that pro- inflammatory dietary patterns may adversely impact kidney health; but this has not been fully investigated, especially in minority populations who bear an excess burden of CKD. Dr. Johns will leverage large, well- established NIH funded cohorts of racial/ethnic minorities with longitudinal data to test the association of diet- induced inflammation with kidney function decline. She will also examine the effects of the Multicultural Healthy Diet (anti-inflammatory dietary pattern) intervention on CKD risk, and the feasibility in individuals with established CKD. Specifically, she aims to: 1) characterize dietary patterns in community-dwelling African Americans (n= 5,306) and Hispanics (n= 16,415) and its associations with systemic inflammation and kidney function decline; 2) evaluate the effect of the Multicultural Healthy Dietary (MHD) intervention on CKD risk in an ongoing clinical trial of older predominately racial/ethnic minority participants (n= 277); and 3) conduct a small pilot study (n= 20) to evaluate the feasibility and acceptability of a MHD-like intervention in racial/ethnic minorities with CKD. To successfully complete these research aims and transition to independence, Dr. Johns has developed a comprehensive 3-year research program that includes: i) mentorship from a multidisciplinary team with expertise in nutrition, longitudinal data analyses for cohort studies, clinical trials, comparative effectiveness studies, and health disparities research; ii) completion of courses in nutritional epidemiology, biostatistics, comparative effectiveness research, and clinical trials; iii) dissemination of her work through presentations at national research meetings and publications in high impact journals; iv) grantsmanship activities geared towards writing a competitive R01 by the end of her award period. Each member of Dr. Johns’ mentorship team has a long track record of successfully mentoring junior investigators, and is fully committed to working together to help her achieve career benchmarks and attain research independence. The resources at Albert Einstein provides an ideal environment in which to complete her training and research goals. With the knowledge and expertise gained from her research and career development activities, Dr. Johns will be well poised to evaluate novel risk factors for CKD, which will inform the development and implementation dietary or other interventions to halt kidney disease initiation and progression in racial/ ethnic minorities. With this award, Dr. Tanya Johns will be well prepared for a career as an independent clinical investigator. (30 lines; Limit 30 lines of text)

项目概要/摘要： 该提案的主要目的是为临床研究人员 Tanya Johns（医学博士、MHS）提供 阿尔伯特·爱因斯坦医学院/ Montefiore Medical 医学系（肾内科） 中心，拥有发展成为独立临床研究员所需的技能和指导 以及一位致力于减少慢性肾脏病 (CKD) 健康差异的全国公认专家。 约翰斯的研究计划探讨了饮食模式与炎症之间的关系及其影响 越来越多的证据表明，与少数族裔的肾功能下降有关。 炎症性饮食模式可能会对肾脏健康产生不利影响；但这一点尚未得到充分研究， 尤其是在患有 CKD 负担过重的少数群体中，约翰斯博士将利用大量、良好的药物。 建立的 NIH 队列资助了少数种族/族裔队列，并利用纵向数据来测试饮食与饮食之间的关系 她还将研究多元文化健康的影响。 饮食（抗炎饮食模式）干预对 CKD 风险的影响，以及对患有 CKD 的个体的可行性 具体而言，她的目标是：1）描述居住在社区的非洲人的饮食模式。 美国人 (n= 5,306) 和西班牙裔 (n= 16,415) 及其与全身炎症和肾脏的关系 功能下降；2) 评估多元文化健康饮食 (MHD) 干预对慢性肾病 (CKD) 风险的影响 正在进行的临床试验主要针对年龄较大的少数族裔参与者（n = 277）；以及 3) 进行一项小型试验； 试点研究（n = 20）评估类似 MHD 的种族/民族干预措施的可行性和可接受性 为了成功完成这些研究目标并过渡到独立，约翰斯博士。 制定了一项为期 3 年的综合研究计划，其中包括： i) 来自多学科专家的指导 团队拥有营养学、队列研究纵向数据分析、临床试验、比较方面的专业知识 有效性研究和健康差异研究；ii) 完成营养流行病学课程， 生物统计学、比较有效性研究和临床试验；iii) 通过传播她的工作； 在国家研究会议上发表演讲并在高影响力期刊上发表论文；iv) 资助； 旨在在获奖期结束时撰写具有竞争力的 R01 的活动。 约翰斯博士的每位成员。 导师团队在成功指导初级研究者方面有着长期的记录，并且完全致力于 共同努力帮助她实现职业基准并获得研究独立性。 阿尔伯特·爱因斯坦提供了一个理想的环境来完成她的培训和研究目标。 约翰斯博士从她的研究和职业发展活动中获得的知识和专业知识将很好 准备评估 CKD 的新危险因素，这将为发展和饮食实施或 阻止少数族裔肾脏疾病发生和进展的其他干预措施。 Tanya Johns 博士将为独立临床研究者的职业生涯做好充分准备（30 行；限制 30 行）。 文本行）