Synergy of lipolysis and lipophagy in alcoholic liver disease

脂肪分解和脂肪吞噬在酒精性肝病中的协同作用

基本信息

批准号：
10392064
负责人：
Micah Schott
金额：
$ 4.1万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-20 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10392064
关键词：
Acid Lipase Address Adipocytes Adipose tissue Adrenergic Agents Affect Alcohol consumption Alcoholic Fatty Liver Alcoholic Liver Diseases Alcoholic beverage heavy drinker Animal Model Autophagocytosis Autophagosome Biochemistry Biological Biology COVID-19 pandemic Catabolism Cells Chronic Cirrhosis Clinic Cyclic AMP Cyclic AMP-Dependent Protein Kinases Data Development Disease Progression Elderly Endosomes Environment Enzymes Ethanol Event Fatty Liver Fibrosis Funding Future Gastroenterology Genetic Transcription Goals Hepatic Hepatitis Hepatocyte Hepatology Hydrolysis Impairment Knowledge Lipase Lipids Lipolysis Liver Lysosomes Malignant Neoplasms Manuscripts Mass Spectrum Analysis Mediating Membrane Microscopy Multivesicular Body Obesity Outcome Pathway interactions Peripheral Pharmacology Pharmacotherapy Phase Phosphotransferases Prevention Process Protein Kinase Protein Sortings Protein phosphatase Proteins Proteome Proteomics Publishing Regulation Research Research Activity Rodent Model Signal Transduction Surface Testing Training Training Activity Triglycerides Vesicle Work base chronic alcohol ingestion in vivo insight liver injury novel parent grant problem drinker protein activation public health relevance receptor recruit response sterol esterase synergism trafficking transcription factor

项目摘要

Project Summary/Abstract The purpose and scope of this supplement is to provide additional funds to mitigate disruptions caused by the COVID19 pandemic on research and training activities related to my parent grant (K99 AA026877). The parent grant seeks to define new mechanisms of lipid catabolism affecting alcoholic liver disease (ALD). The research activities during this period will address Specific Aim 2, which seeks to define a novel, endo-lysosome based mechanism of microlipophagy that is impacted by alcohol consumption. In addition, this supplement will allow me to complete my proposed training in the use of animal models of ALD. The results gained from the proposed research will provide a mechanistic understanding of lipid droplet catabolism in alcoholic fatty liver. Importantly, these studies will provide published research manuscripts and preliminary data in support of a future R01 proposal.

项目概要/摘要此补充的目的和范围是提供额外资金以减轻干扰由新冠病毒大流行引起的与我的家长补助金相关的研究和培训活动（K99 AA026877）。家长资助旨在定义脂质分解代谢的新机制影响酒精性肝病（ALD）。在此期间的研究活动将解决具体目标 2，旨在定义一种新颖的、基于内溶酶体的机制受饮酒影响的微脂肪吞噬。此外，该补充将允许我完成了我提议的使用 ALD 动物模型的培训。取得的成果拟议的研究将提供对脂滴分解代谢的机制理解在酒精性脂肪肝中。重要的是，这些研究将提供已发表的研究手稿以及支持未来 R01 提案的初步数据。