Key Facility Upgrades for the Rutgers University RBL.

罗格斯大学 RBL 的关键设施升级。

• 批准号: 10393791
• 负责人: David Alland
• 金额: $ 332.84万
• 依托单位: RBHS-NEW JERSEY MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393791
• 关键词: 2019-nCoV; Affect; Aging; Air; Animals; Bacillus anthracis; Biological Products; Books; COVID-19; Cells; Chikungunya virus; Consumption; Contracts; DNA; Decontamination; Diagnostic; Emergency Situation; Ensure; Equipment; Failure; Floor; Foundations; Francisella tularensis; Frequencies; Future; Grant; Hydrogen Peroxide; Immunologics; Laboratories; Laboratory Research; Life; Longevity; Maintenance; Manuals; Mission; Mycobacterium tuberculosis; Pathogenesis; Performance; RNA; Research; Research Activity; Research Personnel; Resources; Risk; Safety; Scientist; Security; Services; Stress; System; Therapeutic; Time; Training; United States; United States National Institutes of Health; Universities; Vendor; Work; Yellow fever virus; equipment acquisition; exhaust; foot; improved; instrument; laboratory facility; pathogen; portability; repaired; research facility; vapor; ventilation

PROTECT ABSTRACT The Rutgers University Regional Biocontainment Laboratory (RBL) serves as a central facility to perform biosafety level three (BSL3) research for academic and commercial entities within Rutgers University, the Northeast United States, and beyond. Heavily used for high-threat pathogen research, this facility is now confronted with aging systems including those involved in electrical, flooring, ventilation, security and equipment. These deficiencies place the facility at risk for prolonged shutdowns when repairs or upgrades are needed and threaten our ability to attract and retain first class scientists. This proposal seeks to rectify these deficiencies, returning the Rutgers RBL to a state-of-the-art facility and a critical regional resource. This will be performed in the following aims: 1. Install a second electric feeder cable into the existing double-ended switchgear. 2. Install new high performance epoxy floor system on new substrate. 3. Upgrade the Johnson Controls Building Management System (BMS) serving the RBL HVAC equipment. 4. Replace the existing belt-driven high plume exhaust fans. 5. Replace existing air handling unit (AHU-1,2 & 3) supply fans with fan wall arrays. 6. Install new keypads at all entry points. 7. Upgrade the video surveillance system. 8. Purchase a portable vaporized hydrogen peroxide (VH2O2) system to enable selective room and equipment decontamination. 9. Purchase and install a new state of the art multicolor cell sorter. 10. Purchase a QIAcube instrument to replace manual RNA/DNA extractions. Together, these upgrades and new purchases will ensure that the Rutgers RBL is able to continue its mission to support high-threat pathogen research for the current decade and beyond.

保护摘要 罗格斯大学区域生物防护实验室 (RBL) 作为执行任务的中心设施 罗格斯大学内学术和商业实体的生物安全三级（BSL3）研究 美国东北部及其他地区。该设施广泛用于高威胁病原体研究，现已 面临着老化的系统，包括涉及电气、地板、通风、安全和设备的系统。 这些缺陷使设施在需要维修或升级时面临长期关闭的风险， 威胁到我们吸引和留住一流科学家的能力。该提案旨在纠正这些缺陷， 将罗格斯大学 RBL 恢复为最先进的设施和重要的区域资源。这将在 目标如下： 1. 将第二根馈电电缆安装到现有的双端开关设备中。 2. 安装 新基材上的新型高性能环氧地坪系统。 3. 升级江森自控大楼 为 RBL HVAC 设备提供服务的管理系统 (BMS)。 4.更换现有的皮带驱动高羽 排气扇。 5. 用风扇墙阵列替换现有空气处理装置 (AHU-1,2 & 3) 送风风扇。 6.安装新的 所有入口点都有键盘。 7、升级视频监控系统。 8.购买便携式汽化氢 过氧化物 (VH2O2) 系统可实现选择性房间和设备净化。 9. 购买并安装 新型最先进的多色细胞分选仪。 10.购买QIAcube仪器代替手动RNA/DNA 提取物。总之，这些升级和新采购将确保罗格斯大学 RBL 能够继续 其使命是支持当前十年及以后的高威胁病原体研究。