Supplement to G20AI67347 to complete critical upgrades to the Rutgers RBL

G20AI67347 的补充，以完成罗格斯 RBL 的关键升级

• 批准号: 10631469
• 负责人: David Alland
• 金额: $ 191.33万
• 依托单位: RBHS-NEW JERSEY MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10631469
• 关键词: Aerosols; Animal Experiments; Autopsy; Biochemistry; COVID-19; Clinic; Clinical; Computer Security; Custom; Dental Schools; Equipment; Faculty; Fees; Floor; Funding; Grant; Housing; Individual; Institutes; Intention; Laboratories; Location; Microbiology; Molecular Genetics; New Jersey; Oryctolagus cuniculus; Parents; Procedures; Public Health; Research; Research Institute; Research Personnel; Resources; Rodent; Running; Scientist; Technology; Training; Tuberculosis; United States National Institutes of Health; Universities; University Hospitals; Walking; Work; animal care; biosafety level 3 facility; cost; design; experimental study; international center; medical schools; member; pathogen; public health research; tissue culture

Overview of the RBL. The Rutgers RBL is located at 225 Warren Street in Newark, New Jersey. This location is within a few blocks of the New Jersey Institute of Technology (NJIT) and the Rutgers – Newark main campuses and a seven-minute walk from the Rutgers – New Jersey Medical and Dental School’s campus and the adjoining University Hospital. The RBL is physically attached to the International Center for Public Health (ICPH) building. The RBL provides > 50% of the BSL3 laboratory and BSL3 vivarium (ABSL3) space to the Rutgers campuses. This capacity is augmented by the ICPH building, which also contains additional BSL3 and ABSL3 space that is run along with the RBL as a single facility by the RBL Director, Dr. David Alland. The ICPH houses the Public Health Research Institute, the Rutgers – New Jersey Medical School Department of Microbiology, Biochemistry and Molecular Genetics, and the International Center for Tuberculosis Excellence. A Tuberculosis Clinic is situated in clinical space on the ICPH first floor. Together the facilities and activities in the ICPH building support and augment research performed in the RBL, and investigators performing high threat pathogen research make use of the resources available in the RBL. The first floor of the RBL is fully dedicated as an ABSL3 facility, which includes 6 procedure/housing suites for rodents and rabbits including housing rooms, custom-designed biosafety enclosures, tissue culture labs, procedure rooms, dedicated rooms for aerosol challenge, and a necropsy room. Animal care is supported by per diem fees, while most of the animal experiments are performed by scientists who are certified to work in the facility and supported by individual NIH grants. A new COVID-19 core within the ABSL3 includes BSL3 trained staff who can perform COVID-19 related experiments requiring BSL3 facilities for scientists who are not able to work in the BSL3 by themselves. This core is mostly supported by Rutgers University funds, with the intention to transition this core to eventually be self-sustaining financially. The second floor of the RBL is split equally between BSL3 Lab space and Biosafety Level 2 (BSL2) resident labs and support space, which are headed by several faculty members. The new COVID-19 BSL3 core also uses the facilities on the second floor RBL for COVID-19 core studies.

RBL 概述 罗格斯大学 RBL 位于新泽西州纽瓦克市沃伦街 225 号。 距新泽西理工学院 (NJIT) 和罗格斯大学 - 纽瓦克分校主校区仅几个街区 步行 7 分钟即可到达罗格斯新泽西医学和牙科学校的校园以及毗邻的学校 大学医院附属于国际公共卫生中心 (ICPH) 大楼。 RBL 为罗格斯大学校园提供超过 50% 的 BSL3 实验室和 BSL3 动物园 (ABSL3) 空间。 ICPH 大楼增强了这一容量，该大楼还包含额外的 BSL3 和 ABSL3 空间， ICPH 与 RBL 一起作为单一设施由 RBL 主任 David Alland 博士运营。 罗格斯-新泽西医学院健康研究所微生物学、生物化学系 和分子遗传学，国际结核病卓越中心是结核病诊所。 位于 ICPH 一楼的临床空间，ICPH 大楼内的设施和活动共同支持。 并增强 RBL 中进行的研究，以及进行高威胁病原体研究的研究人员 使用 RBL 中的可用资源。 RBL 的一楼完全专用于 ABSL3 设施，其中包括 6 间手术/住房套房 用于啮齿动物和兔子，包括饲养室、定制设计的生物安全围栏、组织培养实验室、 每个提供手术室、气溶胶挑战专用室和尸检室。 每日费用，而大多数动物实验是由经过认证的科学家进行的 设施并由 NIH 个人拨款支持。ABSL3 内的新的 COVID-19 核心包括接受过 BSL3 培训。 能够执行需要 BSL3 设施的 COVID-19 相关实验的工作人员，而无法为无法执行该实验的科学家提供服务 他们自己在 BSL3 中的工作主要由罗格斯大学的资金支持，目的是 使该核心最终实现财务上的自给自足 RBL 的二楼平分。 BSL3 实验室空间和生物安全 2 级 (BSL2) 常驻实验室和支持空间之间，由 新的 COVID-19 BSL3 核心课程还使用 RBL 二楼的设施。 COVID-19 核心研究。