COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

COBRE 儿童和青少年心理健康睡眠和昼夜节律中心

• 批准号: 10385694
• 负责人: Mary A Carskadon
• 金额: $ 200.97万
• 依托单位: EMMA PENDLETON BRADLEY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-06 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10385694
• 关键词: 17q12; Adolescence; Adolescent; Adolescent Psychiatry; Affect; Attention deficit hyperactivity disorder; Behavioral; Career Mobility; Centers of Research Excellence; Characteristics; Child; Child Mental Health; Child Psychiatry; Child Welfare; Childhood; Chronobiology; Circadian Rhythms; Clinical; Cognitive; Collection; Complex; Computer software; Consultations; Copy Number Polymorphism; Core Facility; Country; DNA copy number; DSM-V; Data; Databases; Development; Diagnostic; Doctor of Philosophy; Drowsiness; Early Intervention; Epidemiologist; Evaluation; Faculty; Family; Feeling suicidal; Functional Magnetic Resonance Imaging; Funding; Genes; Goals; Green space; Growth; Health; Heart; Home; Hospitals; Impaired cognition; Incidence; Infrastructure; Institutes; Institution; Laboratories; Leadership; Link; Longevity; Maintenance; Measures; Memory; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Nature; Occupational activity of managing finances; Participant; Pathway interactions; Phenotype; Pilot Projects; Psychiatrist; Psychologist; Research; Research Methodology; Research Personnel; Resources; Rhode Island; Schizophrenia; Schools; Science; Scientist; Seeds; Sleep; Sleep disturbances; Structure; Technology; Training; United States National Institutes of Health; Vulnerable Populations; Work; Youth; autism spectrum disorder; base; career; circadian; circadian pacemaker; clinical care; design; faculty mentor; health assessment; improved; instrumentation; knowledge base; multidisciplinary; neuropsychiatric disorder; neuropsychiatry; neuropsychopharmacology; preventive intervention; programs; psychobiology; recruit; rumination; sleep behavior; sleep health; sleep pattern; social; suicidal risk; sustainable resource; theories; therapeutic target

PROJECT SUMMARY ABSTRACT This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to prevention and early intervention, not the least because these factors are amenable to behavioral change and to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge base and relevant research methods to the outstanding mental health research and clinical care that characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train, mentor, and support junior investigators toward independent research careers. The Center’s research Cores will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research approaches and methods, and research participants. Four promising young investigators have each proposed a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep, circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene. Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health. Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill its place as a true center of biomedical research excellence is strong, and the most important, special, and notable aspect of this proposed center is the vulnerable population that forms the heart of our work.

项目概要摘要 该 COBRE 将建立儿童和青少年心理睡眠和昼夜节律中心 罗德岛州 EP 布拉德利医院的医疗保健在美国是独一无二的。 专注于儿童的机构和专门研究儿童和青少年的国家资源 精神病学与睡眠之间的联系是无可争议的； 睡眠和昼夜节律对儿科精神疾病和心理健康的影响可以确定重要的途径 预防和早期干预，尤其是因为这些因素容易发生行为改变和 该 COBRE 旨在搭建睡眠和昼夜节律知识之间的桥梁。 杰出的心理健康研究和临床护理的基础和相关研究方法 拟议的 COBRE 中心将是第一个也是唯一一个由 NIH 资助的研究中心。 中心明确关注睡眠、昼夜节律和儿科心理健康。 导师，并支持初级研究人员走向独立研究生涯。 将举办儿科心理健康评估以及睡眠和昼夜节律理论、科学和 该 COBRE 中心的目标是建立和建立一个全面且可持续的方法。 支持儿科睡眠、昼夜节律和心理健康研究发展的资源，同时 为初级项目负责人提供研究和过渡到独立科学的指导 该中心致力于教师、导师、研究人员和研究的多元化。 四位有前途的年轻研究者分别提出了方法和方法以及研究参与者。 项目 1 强调了这项工作的多样性和复杂性，将测量睡眠， 昼夜节律计时和功能磁共振成像来评估有风险的青少年的自我批判性思考和自我安慰 项目 2 评估有自杀倾向的青少年的睡眠模式和昼夜节律。 与自闭症和精神分裂症相关的罕见 DNA 拷贝数变异，包括生物钟基因。 项目 3 评估学童（1-3 年级）绿色空间的使用如何影响睡眠和心理健康。 项目 4 使用强化睡眠和时间生物学实验室方法来确定困倦和记忆力如何影响 患有注意力缺陷多动障碍 (ADHD) 的早期青少年受到睡眠生物调节的影响 该 COBRE 的最终目标是减轻儿童、青少年和青少年面临的这些问题的负担。 通过增强研究人员和能力来实现 COBRE 的承诺。 它作为真正的卓越生物医学研究中心的地位非常牢固，而且最重要、最特殊和最重要 该拟议中心的一个显着方面是弱势群体，他们构成了我们工作的核心。