3D micro-bioprinting: acoustic actuation to shape single-cell organization

3D 微生物打印：声学驱动塑造单细胞组织

• 批准号: DE200100909
• 负责人: Dr David Collins
• 金额: $ 29.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100909
• 关键词: 3D; micro; bioprinting; acoustic; actuation

This project aims to develop an innovative cell-printing technology to replicate the microscale cell structure found in native human and animal tissues. This is based on an interdisciplinary concept that combines ultra-high frequency acoustic cell manipulation with 3D stereolithography printing, and will examine acoustic waveguide element design and their topological optimisation. In contrast to current 3D printing methods that are not suitable for precisely integrating microscale elements in the printing process, this work will open up the range of materials, including functional human tissues, that can be printed.

该项目旨在开发一种创新的细胞打印技术，以复制本地人类和动物组织中发现的微观细胞结构。这是基于一个跨学科概念，该概念将超高频率的声细胞操纵与3D立体光刻印刷结合在一起，并将检查声学波导元素设计及其拓扑优化。与当前不适合在打印过程中精确整合显微镜元素的3D打印方法相反，这项工作将打开可以打印的材料范围，包括功能性人体组织。