Husbandry and Management Core

畜牧与管理核心

基本信息

批准号：
10373933
负责人：
Kamm Prongay
金额：
$ 14.75万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-01-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10373933
关键词：
AIDS-Related Opportunistic Infections AIDS/HIV problem Acquired Immunodeficiency Syndrome Adult Animal Model Animals Anti-Retroviral Agents Artificial Insemination Behavioral Breeding Development Disease Disease Surveillance Female Functional disorder Genetic Variation Goals Grant HIV HIV Infections HIV vaccine Health Herpesvirus 1 Immune response Infant Infection Macaca mulatta Modeling Monitor Mycobacterium tuberculosis Outcome Pathogenesis Persons Pharmaceutical Preparations Practice Management Preventive care Research Resources Risk SIV Serology test Simian Retroviruses Target Populations Therapy Evaluation Vaccine Research Vaccines Virus Weight maintenance regimen Zoonoses animal breeding antiretroviral therapy base clinical care enzootic fight against germ free condition innovation nonhuman primate preservation programs psychologic screening social

项目摘要

PROJECT SUMMARY, Core A: Husbandry and Management Core The U42 SPF 4 Rhesus macaque breeding colony for AIDS research produces MHC class-1 typed rhesus macaques (Macaca mulatta) who are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1), simian retrovirus (type D restrovirus or SRV), and macacine herpesvirus-1 (BV). SPF4 Indian origin rhesus macaques are the premier animal model for HIV/AIDS research, including studies of HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines. Demand for this resource continues to grow, and is projected to increase over the grant cycle. A predictable supply of disease-free, genetically characterized nonhuman primates is critical in the fight against HIV/AIDs. The overall aim of the Husbandry and Management Core is to maintain the ONPRC Specific Pathogen Free (SPF) rhesus macaque breeding colony for AIDS research at a targeted population of 175 adult breeder females capable of producing at least 120 surplus animals annually for research use. To achieve this we will provide innovative team based management practices including new social monitoring strategies, a weight management program for at-risk infants, serologic assays for Mycobacterium tuberculosis screening, and introduction of an artificial insemination program to expand genetic diversity.

项目摘要，核心 A：畜牧和管理核心用于艾滋病研究的 U42 SPF 4 恒河猴繁殖群培育出 MHC 1 类恒河猴猿猴免疫缺陷病毒 (SIV) 阴性、猿猴 T 淋巴细胞性的猕猴 (Macaca mulatta) 病毒 (STLV-1)、猿猴逆转录病毒（D 型逆转录病毒或 SRV）和马卡辛疱疹病毒-1 (BV)。 SPF4 印度人恒河猴是艾滋病毒/艾滋病研究（包括艾滋病毒研究）的首要动物模型发病机制、艾滋病相关的机会性感染以及艾滋病治疗和疫苗的开发。对这一资源的需求持续增长，预计在拨款周期内还会增加。一个可预测的供应无病、具有遗传特征的非人类灵长类动物对于抗击艾滋病毒/艾滋病至关重要。畜牧和管理核心的总体目标是保持 ONPRC 无特定病原体 (SPF) 恒河猴繁殖群，用于艾滋病研究，目标人群为 175 名成年饲养员雌性每年能够生产至少 120 只剩余动物供研究使用。为了实现这一目标，我们将提供基于团队的创新管理实践，包括新的社会监控策略、权重高危婴儿的管理计划、结核分枝杆菌筛查的血清学检测，以及引入人工授精计划以扩大遗传多样性。