7/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT YALE

7/21 ABCD-美国联盟：耶鲁大学研究项目现场

• 批准号: 10373029
• 负责人: Arielle Ryan Baskin-Sommers
• 金额: $ 177.37万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10373029
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adult; Affect; Age; Alcohol consumption; Alcohols; Anxiety; Athletic Injuries; Behavior; Behavioral; Bioinformatics; Biological; Biological Assay; Biology; Brain; Brain imaging; Caffeine; Calendar; Cannabis; Child; Child Health; Childhood; Clinical assessments; Cognition; Cognitive; Communities; Country; Data; Data Analyses; Decision Making; Development; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethics; Event; Feeling suicidal; Female; Funding; Genetic; Health; Impairment; Individual; Informatics; Interview; Life; Link; Logistics; Longitudinal Studies; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Monitor; Neurocognition; Neurocognitive; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Pathway interactions; Persons; Physical activity; Process; Protocols documentation; Psychopathology; Registries; Research; Research Personnel; Research Project Grants; Resource Informatics; Resources; Risk; Role; Sampling; Schools; Science; Secure; Severities; Siblings; Site; Sleep; Social Functioning; Social isolation; Specific qualifier value; Sports; Standardization; Symptoms; Technology; Teenagers; Telephone; Text; Time; Tobacco; Tobacco use; Training; Traumatic Brain Injury; Triplet Multiple Birth; Twin Multiple Birth; United States; Video Games; Youth; adolescent substance use; adverse outcome; cognitive development; cognitive testing; cohort; college; design; emerging adult; emotional factor; experience; follow-up; gene interaction; informatics infrastructure; marijuana use; mobile application; mobile computing; multimodality; neurodevelopment; neuroimaging; novel; participant retention; physical conditioning; recruit; relating to nervous system; research and development; response; retention rate; sleep pattern; social; social media; substance use; temporal measurement; trend; tv watching; vaping; young adult

Abstract Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. The ABCD Research Consortium consists of 21 research sites across the country, a Coordinating Center, and a Data Analysis and Informatics Resource Center. In its first five years, under RFA-DA-15-015, ABCD enrolled a diverse sample of 11,878 9-10 year olds from across the consortium, and will track their biological and behavioral development through adolescence into young adulthood. All participants received a comprehensive baseline assessment, including state-of-the-art brain imaging, neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, and culture and environment. A similar detailed assessment recurs every 2 years. Interim in-person annual interviews and mid-year telephone or mobile app assessments provide refined temporal resolution of developmental changes and life events that occur over time with minimal burden to participating youth and parents. Intensive efforts are made to keep the vast majority of participants involved with the study through adolescence and beyond, and retention rates thus far are very high. Neuroimaging has expanded our understanding of brain development from childhood into adulthood. Using this and other cutting-edge technologies, ABCD can determine how different kinds of youth experiences (such as sports, school involvement, extracurricular activities, videogames, social media, unhealthy sleep patterns, and vaping) interact with each other and with a child’s changing biology to affect brain development and social, behavioral, academic, health, and other outcomes. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental pathways in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences influence brain development; (5) determine and replicate factors that influence mental health from childhood to young adulthood; (6) characterize relationships between mental health and substance use; and (7) specify how use of substances such as cannabis, alcohol, tobacco, and caffeine affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence the risk for adolescent substance use.

抽象的 青少年大脑认知发展（ABCD）是关于大脑发育和认知发展的最大规模的长期研究 ABCD 研究联盟由遍布全美的 21 个研究中心组成。 国家、协调中心以及数据分析和信息学资源中心。 根据 RFA-DA-15-015，ABCD 招募了来自世界各地的 11,878 名 9-10 岁儿童的不同样本 联盟，并将跟踪他们从青春期到青少年的生物和行为发展 成年期。 所有参与者都接受了全面的基线评估，包括最先进的脑成像、 神经心理学测试、生物测定、药物使用仔细评估、心理健康、身体健康、 类似的详细评估每两年进行一次。 访谈和年中电话或移动应用程序评估提供了精确的时间分辨率 随着时间的推移发生的发展变化和生活事件，对参与青少年的负担最小， 家长们付出了巨大努力，让绝大多数参与者参与到这项研究中。 青春期及以后，迄今为止，神经影像学的保留率非常高。 利用这一点和其他前沿技术来了解从童年到成年的大脑发育。 技术，ABCD 可以确定不同类型的青少年经历（例如体育、学校 参与、课外活动、电子游戏、社交媒体、不健康的睡眠模式和电子烟） 彼此之间以及与孩子不断变化的生物学相互作用，以影响大脑发育和社交， 行为、学业、健康和其他结果。 与科学界安全、私密地共享的数据将使研究人员能够：(1) 描述 神经、认知、情感和学术功能方面的个人发展路径，以及 因素；（2）制定国家健康大脑发育的影响标准；（3）研究其作用和 (4) 检查身体活动、睡眠、筛选如何影响基因和环境的相互作用； 时间、运动损伤（包括脑外伤）和其他经历都会影响大脑发育； (5) 确定并复制影响儿童期至成年早期心理健康的因素 (6)； 描述心理健康与物质使用之间的关系；以及 (7) 详细说明物质的使用方式； 例如大麻、酒精、烟草和咖啡因影响发育结果，以及神经、 认知、情感和环境因素影响青少年物质使用的风险。