Mindfulness and Mechanisms of Pain Processing in Adults with Migraines

成人偏头痛患者的正念和疼痛处理机制

• 批准号: 9115533
• 负责人: Rebecca Erwin Wells
• 金额: $ 13.43万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9115533
• 关键词: Address; Adult; Advisory Committees; Affect; Affective; American; Awareness; Brain region; Chronic; Clinical; Clinical Research; Clinical Trials; Cognitive; Complementary Medicine; Control Groups; Cross-Sectional Studies; Data; Dimensions; Discipline; Education; Emotional; Event; Frequencies; Goals; Grant; Headache; Health; Healthcare; Heating; Integrative Medicine; K-Series Research Career Programs; Knowledge; Manuscripts; Measures; Meditation; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Migraine; Mind-Body Intervention; Mission; Modeling; Neurobiology; Outcome; Pain; Pain Measurement; Pain intensity; Pain management; Patients; Pharmaceutical Preparations; Play; Population; Process; Productivity; Randomized Clinical Trials; Reporting; Research; Research Personnel; Research Training; Role; Safety; Sensory; Skills Development; Stress; Techniques; Testing; Time; Training; Writing; Yoga; career; career development; clinical efficacy; cognitive process; cohort; cost; cost efficient; design; disability; evidence base; improved; mindfulness; mindfulness meditation; mindfulness-based stress reduction; multidisciplinary; pilot trial; predicting response; prevent; response; responsible research conduct; sensory mechanism; skill acquisition; skills; skills training; statistics; symposium

 DESCRIPTION (provided by applicant): The goal of the proposed K23 award is to provide the Candidate with the advanced skills and training needed to become an independent investigator evaluating the mechanisms of migraine pain and the efficacy and mechanisms of mind-body interventions for treatment. To facilitate this long-term career goal, the Candidate will examine the sensory and affective responses to experimental pain in migraineurs compared to healthy controls. In addition, the Candidate will assess the impact and mechanisms of an 8-week standardized mind-body intervention, Mindfulness-Based Stress Reduction (MBSR), on the sensory and affective aspects of clinical and experimental pain in adults with migraines, and determine predictors of clinical efficacy. The Candidate has assembled an expert team of mentors to help her achieve these goals. A comprehensive training plan includes important additional training needed in the neurobiology of pain, state-of-the-art methodologies of the quantitative assessment of pain, statistics, formal coursework, and conferences and seminars addressing grant and manuscript writing, as well as other relevant career development topics. The Candidate has assembled a stellar, multidisciplinary mentorship and advisory team tailored to facilitate her research and training with their combined expertise in pain mechanisms, sensory/pain testing, headache, statistics, mind-body medicine, clinical research, and career development. With their support, she will accomplish the following specific training goals: (1) gain advanced training and knowledge in the neurobiology of pain and headache; (2) develop expertise in the quantitative measurements of pain; (3) expand mind-body medicine knowledge and training skills; (4) improve skills in clinical trial methodology and responsible conduct of research; (5) build on statistical skills with further skill training; (6) continue building profesional development skills. The training plan will be conducted in coordination with a proposed set of studies that build upon the Candidate's preliminary data that demonstrated a beneficial effect of MBSR in adults with migraines. The Candidate's proposed research involves three Specific Aims. Aim 1 is designed to assess response to experimental heat pain (pain intensity, pain unpleasantness, emotional reactivity, and pain catastrophizing) in migraineurs (interictally) vs. healthy controls. Aim 2 seeks to test the impact of MBSR in adults with migraines on clinical headache pain, experimental heat pain, mindfulness, pain acceptance, pain catastrophizing, emotional reactivity and headache-related disability compared to an education control group. Aim 3 is to determine the factors that predict MBSR response on clinical headache pain in migraine patients. Successful completion of these aims will advance the understanding of the mechanisms of migraine pain and of mind- body interventions for migraine, and also may be applicable to other clinical pain conditions. The additional training from this K23 will launch the Candidate's career as an independent clinician-investigator and ultimately a leader in the fields of integrative medicine and headache research.

 描述（由适用提供）：拟议的K23奖的目标是为候选人提供一名独立研究者所需的高级技能和培训，以评估偏头痛疼痛的机制以及心身治疗的效率和机制。为了促进这一长期职业目标，候选人将检查与健康对照相比，偏头痛对偏头痛的感觉和情感反应。此外，候选人将评估为期8周的标准化思维干预，基于正念的压力减轻（MBSR）的影响和机制，对偏头痛成人成人临床和实验性疼痛的感觉和情感方面，并确定临床有效性的预测指标。候选人已经组建了一支专业的导师团队，以帮助她实现这些目标。一项全面的培训计划包括疼痛神经生物学所需的重要额外培训，疼痛，统计，正式课程和会议和半导体写作的最先进方法以及其他相关的职业发展主题。该候选人汇集了一个出色的，多学科的心态和咨询团队，该团队量身定制，旨在促进她的研究和培训，并在疼痛机制，感觉/疼痛测试，Headerche，统计学，思想医学，临床研究和职业发展方面的综合专业知识。在他们的支持下，她将实现以下特定的培训目标：（1）获得疼痛和头球神经生物学的高级培训和知识； （2）在疼痛的定量测量中发展专业知识； （3）扩大心身医学知识和培训技巧； （4）提高临床试验方法的技能和负责任的研究； （5）通过进一步的技能培训以统计技能为基础； （6）继续建立专业发展技能。该培训计划将与提议的一组研究进行协调，该研究基于候选人的初步数据，该数据表明MBSR对偏头痛的成年人产生了有益的作用。候选人提议的研究涉及三个具体目标。 AIM 1旨在评估对偏头痛（室内）与健康控制的偏头痛（疼痛强度，疼痛不愉快，情绪反应性和灾难性）的反应。 AIM 2试图测试MBSR在偏头痛成年人对临床标头疼痛，实验性热痛，正念，疼痛接受，疼痛灾难性，情绪反应性和与头球相关的残疾相比的影响。目的3是确定预测偏头痛患者临床标头疼痛的MBSR反应的因素。这些目标的成功完成将提高人们对偏头痛疼痛和偏头痛干预措施的机制的理解，并且可能适用于其他临床疼痛状况。该K23的额外培训将启动 候选人的职业生涯是独立的临床评估者，并最终是综合医学和标题研究领域的领导者。